Thyroiditis following vaccination against COVID-19: Report of two cases and review of the literature

Siolos, Athanasios; Gartzonika, Konstantina; Tigas, Stelios

doi:10.1016/j.metop.2021.100136

Cited by 60 publications

(52 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As with SARS-CoV-2 infection, different forms of thyrotoxicosis after SARS-CoV-2 vaccination have been described, including overt subacute thyroiditis and atypical thyroiditis, as well as autoimmune hyperthyroidism (Graves’ disease) [ 5 , 15 ], as we show in our case series. The general features of these are similar to thyrotoxicosis cases reported in SARS-CoV-2 infection.…”

Section: Discussionsupporting

confidence: 63%

See 1 more Smart Citation

Thyrotoxicosis following SARS-COV-2 vaccination: a case series and discussion

Peris

Alfaro

Royo

et al. 2022

J Endocrinol Invest

View full text Add to dashboard Cite

Aim To describe a case series of thyrotoxicosis likely triggered by SARS-CoV-2 vaccination and to warn physicians about this potential correlation. To report clinical, laboratory and imaging findings and provide further information that goes in line with the underlying mechanisms. Methods Single-center case series based on all the information collected in the hospital medical records, as well as the temporal sequence between the onset of symptoms and COVID-19 vaccination. Results We report 8 cases with thyrotoxicosis after SARS-CoV-2 vaccination. 4 cases of Graves’ disease (GD), 2 cases of subacute painful thyroiditis (SAT), 1 case of concurrent GD and SAT and 1 case of atypical subacute thyroiditis. Five patients received BNT162b2 mRNA vaccine, 3 patients 1273 mRNA vaccine. The onset of symptoms following vaccination ranged from 10 to 14 days in six of eight patients and from 7 to 8 weeks in two patients. Conclusions Several hypotheses have been proposed to explain the potential correlation between SARS-CoV-2 vaccination and thyrotoxicosis, including immune system hyper-stimulation, molecular mimicry and Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA). We should pay greater attention to thyroid disorders in patients receiving vaccine against SARS-CoV-2.

show abstract

Section: Discussionsupporting

confidence: 63%

“…First, immune-mediated complications after SARS-CoV-2 infection are induced by immune system hyper-stimulation and molecular mimicry between the human proteome and SARS-CoV-2 components [ 15 ]. S protein has become a major target for the development of SARS-CoV2 vaccine .…”

Section: Discussionmentioning

confidence: 99%

Thyrotoxicosis following SARS-COV-2 vaccination: a case series and discussion

Peris

Alfaro

Royo

et al. 2022

J Endocrinol Invest

View full text Add to dashboard Cite

show abstract

“…Recently, following the massive vaccination programme worldwide, there have been a few reports of thyroid dysfunction after SARS-CoV-2 vaccination, including SAT [ [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] ] and Graves' disease [ 19 , [29] , [30] , [31] ]. All types of vaccines have been involved, namely inactivated virus SARS-CoV-2 vaccines CORONAVAC [ [13] , [14] , [15] ] and COVAXIN [ 21 ], viral vector-based vaccines VAXZEVRIA [ [16] , [17] , [18] , [19] , [20] , 31 ] and Janssen [ 19 ] and mRNA-based vaccines COMIRNATY [ [22] , [23] , [24] , [25] , [26] , [27] , [28] ] and MODERNA [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, SAT has been described following influenza or hepatitis B vaccination [ [7] , [8] , [9] , [10] , [11] , [12] ]. Recently, cases have been reported of SAT following SARS-CoV-2 vaccination with CoronaVac (Sinovac Life Sciences, China) [ [13] , [14] , [15] ], Vaxzevria (AstraZeneca, Sweden) [ [16] , [17] , [18] , [19] , [20] ], Spikevax (Moderna Biotech, Spain) [ 20 ], Covaxin (Bharat Biotech, India) [ 21 ], and Pfizer-BioNTech SARS-CoV-2 mRNA vaccine (BioNTech, Fosun Pharma, Pfizer, Germany and USA) [ [22] , [23] , [24] , [25] , [26] , [27] , [28] ].…”

Section: Introductionmentioning

confidence: 99%

Recurring subacute thyroiditis after SARS-CoV-2 mRNA vaccine: A case report

Vasileiou

Paschou

Tzamali

et al. 2022

Case Reports in Women's Health

View full text Add to dashboard Cite

SARS-CoV-2 vaccination is the most powerful and promising tool against the COVID-19 pandemic. Millions of people have been vaccinated worldwide. Recently, few cases of subacute thyroiditis following SARS-CoV-2 vaccination with various types of vaccine have been reported of subacute thyroiditis following SARS-CoV-2 vaccination with various types of vaccine. We describe here a 36-year-old woman who presented with subacute thyroiditis 10 days after she had received her first dose of the SARS-CoV-2 mRNA vaccine Comirnaty (Pfizer/BioNTech); the condition receded but then recurred 10 days after she received her second dose. As vaccination programmes proceed, clinicians' attention and vigilance for such cases will be increased. Physicians need to know that subacute thyroiditis is a mild and self-limiting condition in the majority of cases. Last but not least, the benefits of vaccination against COVID-19 outweigh the side-effects reported so far.

show abstract

“…Not surprisingly, in the foreground stand immune or autoimmune mediated processes as possible mechanisms, and the highest frequency of occurrence after the second vaccine dose (after allowing for a presumed sensibilization process to take place after the first dose) seems to strengthen this notion. Besides, mRNA vaccines have been already causally implicated in a number of immune-mediated adverse events such as autoimmune thrombocytopenia and thyroiditis [ 11 , 21 ]. Among others, supported by the relatively frequent occurrence of myocardial damage and myocarditis in the frame of SARS-CoV-2 infection, a mechanism of molecular mimicry between the viral S-protein and various self-antigens (i.e.…”

mentioning

confidence: 99%

Potential implications of lipid nanoparticles in the pathogenesis of myocarditis associated with the use of mRNA vaccines against SARS-CoV-2

et al. 2022

View full text Add to dashboard Cite

Although mRNA-based vaccines BNT162b2 and mRNA-1273 exhibit a remarkable efficacy and effectiveness in preventing particularly severe Covid-19 with an overall favorable adverse event profile, their use has been associated with rare cases of acute myocarditis. These occur most commonly after the second dose, with the highest incidence among young male recipients. This complication has not been observed among adenoviral vector vaccine receivers, and its clinical, laboratory and imaging features resemble those of other common causes of acute myocarditis. The pathogenesis of mRNA-vaccine associated myocarditis has not yet been elucidated, although a number of mechanisms have been proposed, typically implicating the administered S-protein mRNA and likely mediated through an autoimmune mechanism. Nonetheless, other mechanisms may be implicated given the fact that myocarditis cases are very rarely observed among recipients of non mRNA vaccines. The recent observation of a similar adverse event in a recipient of the non-mRNA, peptide-based NVX-CoV2373 in the frame of a phase III clinical trial with 7020 participants in the active treatment arm raises the question whether the lipid nanoparticle sheath, which is a common structural component of these platforms could be implicated in the pathogenesis of vaccine-induced myocarditis.

show abstract

Thyroiditis following vaccination against COVID-19: Report of two cases and review of the literature

Cited by 60 publications

References 23 publications

Thyrotoxicosis following SARS-COV-2 vaccination: a case series and discussion

Thyrotoxicosis following SARS-COV-2 vaccination: a case series and discussion

Recurring subacute thyroiditis after SARS-CoV-2 mRNA vaccine: A case report

Potential implications of lipid nanoparticles in the pathogenesis of myocarditis associated with the use of mRNA vaccines against SARS-CoV-2

Contact Info

Product

Resources

About