Thyroïdite et intolérance au gluten: maladies auto-immmunes extrapancréatiques associées au diabète de type 1

Faesch, S.; Jennane, F.; Izembart, I.; Chatenoud, Lucienne; Taupin, Pierre; Martin, Delphine; Polak, Michel; Robert, J. J.

doi:10.1016/j.arcped.2006.09.025

Cited by 9 publications

(1 citation statement)

References 31 publications

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“…measurements and reference values for antibodies, possibly explains another part of the heterogeneity between studies. For example, reference values for TSH indicating (auto-immune) hypothyroidism varied from >4.0 up to >10 mU/L (48,49,50,51), usually but not always (49,51,52) dependent on fT4 levels to determine if the condition was classified as clinical overt or subclinical disease. In most studies, only hypothyroid patients with antibody positivity were considered as having autoimmune hypothyroidism (9,41,44,53,54,55,56,57) and others included ultrasound to confirm the diagnosis (58) or both (59,60,61,62,63).…”

Section: Figurementioning

confidence: 99%

Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis

Nederstigt

Uitbeijerse

Janssen³

et al. 2019

European Journal of Endocrinology

100

105

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Introduction:The association between type 1 diabetes (T1D) and other auto-immune diseases is well known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking. Methods: We searched PubMed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo and adrenal gland insufficiency. A meta-analysis was performed to estimate pooled prevalence using a random-effects model. Furthermore, randomeffects meta-regression analysis was performed to assess the association between prevalence and mean age or diabetes duration. Results: One hundred eighty articles were eligible including a total of 293 889 type 1 diabetes patients. Hypothyroidism (65 studies) was prevalent in 9.8% (95% CI: 7.5-12.3) of patients. Meta-regression showed that for every 10-year age increase, hypothyroidism prevalence increased 4.6% (95% CI: 2.6-6.6, P < 0.000, 54 studies). Weighted prevalence of celiac disease was 4.5% (95% CI: 4.0-5.5, 87 studies). Gastric autoimmunity was found in 4.3% of patients (95% CI: 1.6-8.2, 8 studies) and vitiligo in 2.4% (95% CI: 1.2-3.9, 14 studies) of patients. The prevalence of adrenal insufficiency was 0.2% (95% CI: 0.0-0.4, 14 studies) and hyperthyroidism was found in 1.3 percent (95% CI: 0.9-1.8, 45 studies) of type 1 diabetes patients. For all analyses, statistical heterogeneity between studies was moderate to high. Conclusions: The prevalence of antibody-mediated auto-immune disease is high among type 1 diabetes patients. Especially hypothyroidism and celiac disease are frequently found.

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Section: Figurementioning

confidence: 99%

Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis

Nederstigt

Uitbeijerse

Janssen³

et al. 2019

European Journal of Endocrinology

100

105

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Autoimmune thyroid disease in Libyan children and young adults with type 1 diabetes mellitus

et al. 2011

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The prevalence of autoimmune thyroid disease in type 1 diabetic patients is higher than in the general population. A routine screening strategy should be implemented with the determination of anti-thyroid antibodies and TSH in type 1 diabetic patients, particularly in girls, and in patients with diabetes of more than 5 years duration. Patients who have positive TPO antibodies may need the assessment of thyroid function at shorter intervals.

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An analysis of the prevalence of thyroid autoantibodies: thyroid peroxidase antibodies (ATA) and thyroglobulin antibodies (ATG) in children with newly diagnosed diabetes mellitus type 1 during 2000–2004 in the Upper Silesia region, Poland

et al. 2007

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The aim of this study was to evaluate the prevalence of thyroid autoantibodies and clinical significance of thyroid autoimmunity in children with the diagnosis of diabetes mellitus type 1. The study group comprised 222 children all with newly diagnosed diabetes mellitus type 1 (122 boys) with a mean age 9.92 +/- 4.5 years, who were admitted to a regional diabetes division in 2000-2004. Assessment of ATA and ATG were performed and two emerging groups-ATA/ATG (+) and ATA/ATG (-) were compared, including anthropometric data, HbA1C, plasma lipids, TSH, fT4. Positive antibodies titre was found in 27 (12.16%) of the children. Apart from older age in the antibody positive group (11.67 vs. 9.67 years, p < 0.05), there were no significant differences among these groups regarding other clinical and laboratory characteristics. Concluding, the presence of thyroid autoantibodies in 12.16% of subjects with newly diagnosed diabetes confirms the necessity of screening of all children, especially adolescents from the time of diagnosis of diabetes mellitus type 1 onwards. No association between existence of autoantibodies and the clinical status of a child at the presentation of diabetes was demonstrated by this study.

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Thyroïdite et intolérance au gluten: maladies auto-immmunes extrapancréatiques associées au diabète de type 1

Cited by 9 publications

References 31 publications

Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis

Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis

Autoimmune thyroid disease in Libyan children and young adults with type 1 diabetes mellitus

An analysis of the prevalence of thyroid autoantibodies: thyroid peroxidase antibodies (ATA) and thyroglobulin antibodies (ATG) in children with newly diagnosed diabetes mellitus type 1 during 2000–2004 in the Upper Silesia region, Poland

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