Thyroidectomy induces coated pit formation on cerebellar mossy fiber terminals

Paula‐Barbosa, M. M.; Tavares, M. A.; Ruela, C.; Matos-Lima, L.; Gray, E. G.

doi:10.1007/bf00219241

Cited by 3 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The selection of cerebellum as the target brain region of this study was based primarily on the direct connection of AOH with phenotypic alterations of the cerebellum core functions, including ataxia and lack of motor coordination. These symptoms have been mainly attributed to morphological alterations, 28 changes in myelin sheath turnover, and modification in several neurotransmitter systems. 24,29,30 In this paper, it will be shown that significant metabolic alterations also occur, which could further support the phenotypic manifestations of the disease into movement dysfunctions.…”

Section: Introductionmentioning

confidence: 99%

GC−MS Metabolomic Analysis Reveals Significant Alterations in Cerebellar Metabolic Physiology in a Mouse Model of Adult Onset Hypothyroidism

et al. 2010

View full text Add to dashboard Cite

Although adult-onset hypothyroidism (AOH) has been connected to neural activity alterations, including movement, behavioral, and mental dysfunctions, the underlying changes in brain metabolic physiology have not been investigated in a systemic and systematic way. The current knowledge remains fragmented, referring to different experimental setups and recovered from various brain regions. In this study, we developed and applied a gas chromatography-mass spectrometry (GC-MS) metabolomics protocol to obtain a holistic view of the cerebellar metabolic physiology in a Balb/cJ mouse model of prolonged adult-onset hypothyroidism induced by a 64-day treatment with 1% potassium perchlorate in the drinking water of the animals. The high-throughput analysis enabled the correlation between multiple parallel-occurring metabolic phenomena; some have been previously related to AOH, while others implicated new pathways, designating new directions for further research. Specifically, an overall decline in the metabolic activity of the hypothyroid compared to the euthyroid cerebellum was observed, characteristically manifested in energy metabolism, glutamate/glutamine metabolism, osmolytic/antioxidant capacity, and protein/lipid synthesis. These alterations provide strong evidence that the mammalian cerebellum is metabolically responsive to AOH. In light of the cerebellum core functions and its increasingly recognized role in neurocognition, these findings further support the known phenotypic manifestations of AOH into movement and cognitive dysfunctions.

show abstract

Section: Introductionmentioning

confidence: 99%

GC−MS Metabolomic Analysis Reveals Significant Alterations in Cerebellar Metabolic Physiology in a Mouse Model of Adult Onset Hypothyroidism

et al. 2010

View full text Add to dashboard Cite

show abstract

Effects of hypothyroidism upon the granular layer of the dentate gyrus in male and female adult rats: A morphometric study

Madeira¹,

Cadete‐Leite²,

Andrade³

et al. 1991

J of Comparative Neurology

View full text Add to dashboard Cite

The effects of hypothyroidism upon the structure of the central nervous system of adult rats are poorly understood in spite of evidence that the mature brain is vulnerable to this condition. Existing developmental studies show that the morphological changes induced by thyroid hormone deficiency are related to alterations in neurogenesis. We studied the granular layer of the dentate gyrus under different experimental conditions of hypothyroidism, because in rodents the neurogenesis of the granule cells continues during adulthood. The following groups of rats were analysed: 1) control; 2) hypothyroid from day 0 until day 180 (hypothyroid group); 3) hypothyroid until day 30 and henceforth maintained euthyroid (recovery group); and 4) hypothyroid since day 30 (adult hypothyroid group). Groups of 6 male rats and 6 female rats were analysed separately. The volume of the dentate gyrus granular layer and the numerical density of its neurons were evaluated, so we were able to estimate the total number of granule cells. Because in the experimental groups the volume of the granular layer and the numerical density of its neurons were reduced, the total number of granule cells was decreased. In the hypothyroid and recovery groups the alterations were identical and more striking than in the adult hypothyroid groups. The total number of granule cells displayed sexual differences in all groups studied except in the hypothyroid groups. The present results support the view that thyroid hormone deficiency interferes with the process of cell acquisition by reducing neuronal proliferation and that it also leads to increased cell death. These events underlie the irreversible morphological changes observed in the brain of hypothyroid rats, either during development or at maturity. The referred structural alterations are probably related to the functional deficits observed in this condition.

show abstract

Stereological Analysis of the Hippocampal Formation of Male and Female Hypothyroid Rats

Madeira¹,

Andrade²

1995

Behavioural Brain Research in Naturalistic and Semi-Naturalistic Settings

View full text Add to dashboard Cite

Thyroidectomy induces coated pit formation on cerebellar mossy fiber terminals

Cited by 3 publications

References 31 publications

GC−MS Metabolomic Analysis Reveals Significant Alterations in Cerebellar Metabolic Physiology in a Mouse Model of Adult Onset Hypothyroidism

GC−MS Metabolomic Analysis Reveals Significant Alterations in Cerebellar Metabolic Physiology in a Mouse Model of Adult Onset Hypothyroidism

Effects of hypothyroidism upon the granular layer of the dentate gyrus in male and female adult rats: A morphometric study

Stereological Analysis of the Hippocampal Formation of Male and Female Hypothyroid Rats

Contact Info

Product

Resources

About