Thyroid volume, selenium levels and nutritional habits in a rural region in Albania

Doupis, John; Stavrianos, Charalambos; Saltiki, Katerina; Mantzou, Emily; Mastrokostopoulos, Antonios; Philippou, George; Alevizaki, Maria

doi:10.14310/horm.2002.1246

Cited by 10 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, serum Se concentrations from a population of elderly healthy Swedes were low (~ 67.1 μg/l) compared with the reported Se levels in the United States 25 , 26 and also relatively low in comparison with values in other regions in Europe. 18 , 19 , 27 , 28 , 29 , 30 , 31 , 32 The difference in concentrations between smokers and non-smokers in the present study was not significant, which may be an effect of the small size of the smoking group ( n =40; 9.0%), as some studies have found decreased levels in current smokers. 33 , 19 However, there are also studies where such an association has not been found.…”

Section: Discussioncontrasting

confidence: 82%

Relatively high mortality risk in elderly Swedish subjects with low selenium status

et al. 2015

View full text Add to dashboard Cite

Background/Objectives:The daily dietary intake of selenium (Se), an essential trace element, is still low in Sweden in spite of decades of nutritional information campaigns and the effect of this on the public health is presently not well known. The objective of this study was to determine the serum Se levels in an elderly Swedish population and to analyze whether a low Se status had any influence on mortality.Subjects/Methods:Six-hundred sixty-eight (n=668) elderly participants were invited from a municipality and evaluated in an observational study. Individuals were followed for 6.8 years and Se levels were re-evaluated in 98 individuals after 48 months. Clinical examination of all individuals included functional classification, echocardiography, electrocardiogram and serum Se measurement. All mortality was registered and endpoints of mortality were assessed by Kaplan–Meier plots, and Cox proportional hazard ratios adjusted for potential confounding factors were calculated.Results:The mean serum Se level of the study population (n=668) was 67.1 μg/l, corresponding to relatively low Se intake. After adjustment for male gender, smoking, ischemic heart disease, diabetes, chronic obstructive pulmonary disease and impaired heart function, persons with serum Se in the lowest quartile had 43% (95% confidence interval (CI): 1.02–2.00) and 56% (95% CI: 1.03–2.36) increased risk for all-cause and cardiovascular mortality, respectively. The result was not driven by inflammatory effects on Se concentration in serum.Conclusion:The mean serum Se concentration in an elderly Swedish population was 67.1 μg/l, which is below the physiological saturation level for several selenoprotein enzymes. This result may suggest the value of modest Se supplementation in order to improve the health of the Swedish population.

show abstract

Section: Discussioncontrasting

confidence: 82%

Relatively high mortality risk in elderly Swedish subjects with low selenium status

et al. 2015

View full text Add to dashboard Cite

show abstract

“…John et al [12] found that when the intake of selenium was sufficient, there was no correlation between goiter and serum selenium levels even in a mild iodine-deficient area. A study in school-age children in Turkey [22] with moderate iodine deficiency, found that mean selenium was 50 μg/L, a relatively low level, and serum selenium concentration was not associated with thyroid volume, thyroid goiter, or THS levels.…”

Section: Discussionmentioning

confidence: 99%

“…The cut-off levels were derived from the mean (+2 SD) thyroid volume in 597 subjects (315 males and 282 females) without thyroid dysfunction, without a previous thyroid disease, without a family history of thyroid disease, without positive thyroid autoantibodies, and without goiter or nodules on ultrasonography [12]. …”

Section: Methodsmentioning

confidence: 99%

Thyroid volume, goiter prevalence, and selenium levels in an iodine-sufficient area: a cross-sectional study

et al. 2013

View full text Add to dashboard Cite

BackgroundSelenium (Se) is a necessary element for the biosynthesis of thyroid hormones. We investigated the relationship between selenium status, thyroid volume, and goiter in a cross-sectional study in an iodine-sufficient area.MethodsWe selected residents of Chengdu (over 18 years old and living in the city for more than 5 years) using a stratified cluster sampling technique. Fifteen hundred subjects were selected for the study, which involved a questionnaire survey, physical examination, thyroid ultrasound, serum thyroid function test, and determination of serum selenium level. Thyroid volume was calculated from the thickness, width, length, and a corrective factor for each lobe. Ultimately, 1,205 subjects completed the investigation and were included in our study. Additionally, 80 school-age children were selected to provide urine samples for urinary iodine analysis. We analyzed the data using appropriate nonparametric and parametric statistical tests.ResultsThe median urinary iodine value was 184 μg/L in school-age children, indicating iodine sufficiency. The median serum selenium level of the 1,205 subjects was 52.63 (interquartile range [IQR] : 40.40-67.00) μg/L. The median thyroid volume was 9.93 (IQR: 7.71-12.57) mL; both log-transformed serum selenium and log-transformed thyroid volume were Gaussian distributions (P = .638 and P = .046, respectively). The prevalences of goiter and thyroid nodules were 8.8% and 18.6%. The prevalences of positive thyroid autoantibodies, thyroperoxidase autoantibodies and thyroglobulin autoantibodies were 16.7%, 12.0%, and 11.1%, respectively. In the general linear regression model, there were positive associations between serum selenium and age, and body mass index. We found no association between serum selenium and thyroid-stimulating hormone. In simple linear regression analyses, we found no association between thyroid volume and serum selenium. There were no significant differences in serum selenium between persons with or without goiter. Serum selenium was not a risk factor for goiter.ConclusionIn our study population, serum selenium was neither associated with thyroid volume nor with goiter in an iodine-sufficient area. More studies should be conducted by following non-goitrous persons over time and monitoring their selenium status.

show abstract

“…9,32 In adults with Se deficiency, an increased propensity for neoplastic diseases was detected (particularly for malignant tumours of prostate, breast and colon), certain thyroid diseases, neuropsychiatric disturbances and disturbance of fertility proved to be more frequent. 12,[33][34][35][36] A lowered serum Se concentration was detected in women with frequent abortions, in men with diagnosis of oligospermia. 11 In recent years, deficiency of Se was found to be significant in pathogenesis of circulatory diseases.…”

Section: Discussionmentioning

confidence: 99%

The relationship between environmental exposure to cadmium and lead and blood selenium concentration in randomly selected population of children inhabiting industrial regions of Silesian Voivodship (Poland)

et al. 2013

View full text Add to dashboard Cite

This study aimed at determining the relationship between environmental exposure to lead (Pb) and cadmium (Cd) and blood selenium (Se) concentration in randomly selected population of children inhabiting the industrial regions of Silesian Voivodship, Poland. The study was conducted on a group of consecutive randomly selected 349 children aged below 15 years and inhabiting the industrial regions in Upper Silesia. The examined variables included whole blood Cd concentration (Cd-B), whole blood Pb concentration (Pb-B) and whole blood Se concentration (Se-B). The concentration of Cd-B, Pb-B and Se-B in the studied group of children amounted to 0.26 ± 0.14, 37.62 ± 25.30 and 78.31 ± 12.82 μg/L, respectively. In the entire examined group a statistically significant negative linear relationship was noted between Pb-B and Se-B ( r = −0.12, p < 0.05). Also, a statistically insignificant negative correlation was detected between Cd-B and Se-B ( r = −0.02, p > 0.05) and a statistically insignificant positive correlation between Pb-B and Cd-B ( r = 0.08, p > 0.05). A multivariate backward stepwise regression analysis demonstrated that in the studied group of children higher Pb-B and a more advanced age-represented independent risk factors for a decreased Se-B. Environmental exposure to Pb may represent an independent risk factor for Se deficit in blood of the studied population of children. In children, the lowered Se-B may create one of the mechanisms in which Pb unfavourably affects human body.

show abstract

Thyroid volume, selenium levels and nutritional habits in a rural region in Albania

Cited by 10 publications

References 26 publications

Relatively high mortality risk in elderly Swedish subjects with low selenium status

Relatively high mortality risk in elderly Swedish subjects with low selenium status

Thyroid volume, goiter prevalence, and selenium levels in an iodine-sufficient area: a cross-sectional study

The relationship between environmental exposure to cadmium and lead and blood selenium concentration in randomly selected population of children inhabiting industrial regions of Silesian Voivodship (Poland)

Contact Info

Product

Resources

About