Thyroid volume, iodine intake, autoimmune thyroid disorders, inborn factors, and endocrine disruptors: twenty-year studies of multiple effects puzzle in Slovakia

Langer, P; Tajtáková, M; Kočan, Anton; Drobná, Beata; Kostalova, Ludmila; Fodor, G; Klimeš, I

doi:10.4149/endo_2012_04_191

Cited by 11 publications

(8 citation statements)

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“…Among 6 regions in the world, children in Japan, as representatives of the Asian region, had both the largest age-adjusted thyroid volumes and the largest body surface area-adjusted thyroid volumes. After publishing these data, recent studies on thyroid volume confirmed the international reference values although the number of cases are small (approximately 200-5000 cases) in all studies [11][12][13][14][15][16]. In Japan, Fuse et al compared the international reference values for Japanese and thyroid volumes of approximately 1000 schoolchildren [11].…”

Section: Discussionmentioning

confidence: 78%

Systematic determination of thyroid volume by ultrasound examination from infancy to adolescence in Japan: The Fukushima Health Management Survey

et al. 2015

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Section: Discussionmentioning

confidence: 78%

Systematic determination of thyroid volume by ultrasound examination from infancy to adolescence in Japan: The Fukushima Health Management Survey

et al. 2015

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“…Numerous environmental agents can produce marginal reductions of circulating THs. Although it is well documented that severe developmental hypothyroidism is profoundly detrimental to neurodevelopment, less information is available on the effects of modest TH deficits or on the impact of low-level TH disruptions induced by environmental contaminants, including endocrine-disrupting chemicals (EDCs) (36). There is increasing epidemiological evidence on the influence of environmental exposure to low doses of EDCs in some human diseases and disabilities (36,37).…”

Section: European Journal Of Endocrinologymentioning

confidence: 99%

Thyroid status and its association with cognitive functioning in healthy boys at 10 years of age

Pérez-Lobato

Ramos

Arrebola

et al. 2015

European Journal of Endocrinology

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Objective: Thyroid hormones (THs) are crucial for the correct maturation of the CNS and the neurodevelopment of the child. We aimed to investigate the association of TSH and free thyroxine (FT 4 ) levels with cognitive functioning in children from the INMA-Granada cohort studied during their follow-up at the age of 9-11 years. Design: We evaluated 300 children from the original cohort, which comprised 668 eligible mother-son pairs recruited at birth from 2000 to 2002 in Granada (Spain). Methods: FT 4 and TSH concentrations were measured, and cognitive development was assessed using neuropsychological tests (nZ187). Children with chronic disease related to thyroid function and/or cognitive development were excluded. Results: Median TSH and FT 4 levels were 3.1 mIU/ml and 1.2 ng/dl respectively. In multivariable regression analyses adjusted for maternal and child characteristics, children with TSH levels in the top tertile had worse verbal comprehension and immediate and long-term recall. Children with FT 4 levels in the top tertile had better attention and lower impulsivity and were at a lower risk of scoring below the 20th percentile in intelligence quotient (ORZ0.24; 95% CIZ0.08-0.74; PZ0.013) and in abstract reasoning ability (ORZ0.28; 95% CIZ0.09-0.88; PZ0.029). Conclusion: Our findings indicate that circulating THs and TSH may in the top tertile have an impact on cognitive functions; thus, higher TSH slightly but significantly increased the risk of a lower score in certain neuropsychological tests.

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“…HT is a kind of common clinical autoimmune thyroid disease,the etiology is no clear,the clinical manifestations are various,iodine intake is an important environmental factor affecting the development of the disease.In recent years,with the popularization of iodized salt,iodine intake gradually increased,the incidence of this disease increased significantly [4] .The typical pathological changes are the infiltration of a large number of lymphocytes and the proliferation of connective tissue in different degrees.High autoantibodies titer of thyroid-resistant components can be detected in the patients' serum,such as TPOAb and TgAb.Because the disease is more obscure,the patients don't come to see a doctor until hyperthyroidism or hypothyroidism symptoms exists or histological diagnosis was confirmed due to the operation of thyroid nodule of tumor [5] .…”

Section: Discussionmentioning

confidence: 99%

Investigation of correlation between autoimmune antibodies and real-time ultrasound elastosonography scores in patients with Hashimoto’s Thyroiditis

2019

Preprint

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Objective To investigate the correlation between autoimmune antibodies,ultrasonic elasticity scores,elasticity coefficients in patients with Hashimoto’s thyroiditis.Methods Detected the thyroid function,the thyroid globulin antibody (TgAb) and the titer of thyroid peroxides antibody(TPOAb) by chemiluminescence from the fasting serum of 258 patients suffering with Hashimoto’s thyroiditis; The ultrasonic elasticity scores and elasticity coefficients were evaluated after detecting the patients’ thyroid with GELOGIQ3 type Color Doppler Ultrasound Diagnostic System and getting a satisfactory elastosonography.Then the correlation between autoimmune antibodies,ultrasonic elasticity scores and elasticity coefficients were analyzed respectively.Results Serum thyroid stimulating hormone (TSH),TGA and TPO in 258 patients with HT increased significantly,the titer of TgAb was positively correlated with elastic coefficients,r=0.62,P<0.001,and also positively correlated with elastic scores,r=0.65,P<0.001;TPOAb was positively correlated with elastic coefficients,r=0.63,P<0.001,and positively correlated with elastic scores as well,r=0.62,P<0.001.Conclusions It’s helpful to increase the accuracy rate of HT diagnosis with detection of thyroid autoimmune function combined with Real-time ultrasound elastosonography scores.

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Thyroid volume, iodine intake, autoimmune thyroid disorders, inborn factors, and endocrine disruptors: twenty-year studies of multiple effects puzzle in Slovakia

Cited by 11 publications

References 0 publications

Systematic determination of thyroid volume by ultrasound examination from infancy to adolescence in Japan: The Fukushima Health Management Survey

Systematic determination of thyroid volume by ultrasound examination from infancy to adolescence in Japan: The Fukushima Health Management Survey

Thyroid status and its association with cognitive functioning in healthy boys at 10 years of age

Investigation of correlation between autoimmune antibodies and real-time ultrasound elastosonography scores in patients with Hashimoto’s Thyroiditis

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