Thyroid tumors: are we unveiling the puzzle?

Ward, Laura Sterian

doi:10.1530/erc-14-0407

Cited by 5 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thyroid cancer is the most common type of endocrine malignancy, which accounts for nearly 3% of all malignancies [ 1 ]. Despite low mortality rate, rates of local recurrence and distant metastases are high in thyroid cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Reproductive Factors but Not Hormonal Factors Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis

Cao

Wang

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

Many studies have investigated the association between hormonal and reproductive factors and thyroid cancer risk but provided contradictory and inconclusive findings. This review was aimed at precisely estimating this association by pooling all available epidemiological studies. 25 independent studies were retrieved after a comprehensive literature search in databases of PubMed and Embase. Overall, common hormonal factors including oral contraceptive and hormone replacement therapy did not alter the risk of thyroid cancer. Older age at menopause was associated with weakly increased risk of thyroid cancer in overall analysis (RR = 1.24, 95% CI 1.00–1.53, P = 0.049); however, longer duration of breast feeding was related to moderately reduced risk of thyroid cancer, suggested by pooled analysis in all cohort studies (RR = 0.7, 95% CI 0.51–0.95, P = 0.021). The pooled RR in hospital-based case-control studies implicated that parous women were more susceptible to thyroid cancer than nulliparous women (RR = 2.30, 95% CI 1.31–4.04, P = 0.004). The present meta-analysis suggests that older age at menopause and parity are risk factors for thyroid cancer, while longer duration of breast feeding plays a protective role against this cancer. Nevertheless, more relevant epidemiological studies are warranted to investigate roles of hormonal and reproductive factors in thyroid carcinogenesis.

show abstract

Section: Introductionmentioning

confidence: 99%

Reproductive Factors but Not Hormonal Factors Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis

Cao

Wang

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Thyroid cancer (TC), the most common malignant tumor among endocrine and head–neck tumors, with an increasing incidence in recent years, accounts for ~3% of all malignancies. 1 Differentiated thyroid cancer (DTC) accounts for >90% of all TC cases. Currently, the routine treatment for DTC is surgery plus 131 I therapy plus thyroid-stimulating hormone (TSH) suppression therapy.…”

Section: Introductionmentioning

confidence: 99%

Values of 99mTc-methoxyisobutylisonitrile imaging after first-time large-dose 131I therapy in treating differentiated thyroid cancer

Pan

Dong

Zhu

et al. 2016

OTT

View full text Add to dashboard Cite

ObjectiveThe aim of this study is to investigate the use of 99mTc-methoxyisobutylisonitrile (MIBI) imaging for evaluating the treatment response of differentiated thyroid cancer (DTC) after the first administration of a high dose of 131I.MethodsPatients with DTC who received 131I therapy underwent 99mTc-MIBI imaging after successive increases in the therapeutic dose of 131I, and the serum levels of thyroglobulin (Tg) were measured.ResultsA total of 191 patients were enrolled in the final analysis, including 65 metastases and/or thyroid remnant-positive patients (22 patients with metastases and 43 patients with thyroid remnants). The sensitivity of 99mTc-MIBI imaging for detecting positive cases and thyroid remnants was 56.9% and 39.5%, respectively, which was significantly lower than that of 131I imaging (92.3% and 100%, respectively, P<0.01 for both). The sensitivity of 99mTc-MIBI imaging for detecting metastases was 90.9%, which was slightly higher than that of 131I imaging (77.3%, P>0.05). The Tg levels in the positive group were significantly higher than that in the negative group (P<0.01). In addition, the Tg levels in the 99mTc-MIBI+/131I− group were significantly higher than that in the 131I+/99mTc-MIBI group (P<0.05).ConclusionAfter the first 131I therapy, although 99mTc-MIBI imaging was able to detect the existence of metastatic lesions in patients with DTC better, its assessment for the removal efficiency of thyroid remnants was unsatisfactory. The results of 99mTc-MIBI imaging showed good correlations with the Tg level.

show abstract

“…The vertiginous expansion of knowledge about endocrinology brings some caveats to the clinical practice. For instance, differentiated thyroid cancer, which was a relatively uncommon neoplasia 40 years ago, has been increasing more than any other type of cancer in the last decade . In fact, it became the most common neoplasia in women of certain countries .…”

mentioning

confidence: 99%

“…However, despite this impressive increase in incidence, differentiated thyroid cancer mortality rates remain like 40 years ago . Multiple reasons can explain this phenomenon, including the fact that the increase in incidence is most due to microcarcinomas and cancers with a “benign” pattern that probably would had never evolved if not identified by ultrasonography or other modern sensitive image methods …”

mentioning

confidence: 99%

See 1 more Smart Citation

Thyroid function after TSH suppression for thyroid cancer: When is optimal time to check?

Ward

Villagelin

2017

Clinical Endocrinology

View full text Add to dashboard Cite

Thyroid tumors: are we unveiling the puzzle?

Cited by 5 publications

References 9 publications

Reproductive Factors but Not Hormonal Factors Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis

Reproductive Factors but Not Hormonal Factors Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis

Values of 99mTc-methoxyisobutylisonitrile imaging after first-time large-dose 131I therapy in treating differentiated thyroid cancer

Thyroid function after TSH suppression for thyroid cancer: When is optimal time to check?

Contact Info

Product

Resources

About