Thyroid transcription factor–1 expression in thyroid-like nasopharyngeal papillary adenocarcinoma: report of 2 cases

Carrizo, Fernando; Luna, Mario A.

doi:10.1016/j.anndiagpath.2005.04.019

Cited by 63 publications

(67 citation statements)

References 16 publications

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“…In all other published studies on LGPACNP, we have neither found this feature commented on nor documented. The immunohistochemical profile of our tumor is identical to what has been published previously [1][2][3][4][5][6][7][8][9]. The fact that some of these neoplasms display nuclear expression of TTF-1 and some do not is intriguing.…”

Section: Discussionsupporting

confidence: 79%

“…Since then one series (comprising 13 cases; from Mario Luna at MD Anderson Cancer Center in 2006) and a few case reports have been published on this neoplastic entity [2][3][4][5][6][7][8][9][10]. In 2005 Carrizo and Luna presented 2 cases of LGPACNP with nuclear positivity for thyroid transcription factor-1 (TTF-1) [2]. Based on this immunohistochemical feature (and the positivity for cytokeratin 19) in conjunction with the histological characteristics (papillarity, psammoma bodies, neoplastic cells with overlapping nuclei and clear chromatin), the authors coined the term ''thyroid-like nasopharyngeal papillary adenocarcinoma'', which has been used by subsequent investigators.…”

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Biphasic Low-Grade Nasopharyngeal Papillary Adenocarcinoma with a Prominent Spindle Cell Component: Report of a Case Localized to the Posterior Nasal Septum

Petersson

Pang

Loke³

et al. 2011

Head and Neck Pathol

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A case (female, 39 years of) of thyroid-like nasopharyngeal low-grade papillary adenocarcinoma with a significant spindle cell component is presented. The tumor was located on the posterior nasal septum. The spindle cells displayed nuclear features very much similar to the epithelial component and the two cell types merged imperceptibly. Immunohistochemically, the neoplastic cells (including the spindle cell component) were strongly and diffusely positive for TTF-1, cytokeratins (AE1-3), cytokeratin 19 and vimentin. C-kit immunohistochemistry showed diffuse mild to moderate membranous positivity with focal areas displaying moderate to strong immunoreactivity. EMA was strongly positive in the epithelial component with membranous and cytoplasmic reactivity whereas the spindle cell component was weakly although diffusely positive. Carcinoembryonic antigen, calcitonin, chromogranin A, S100-protein, thyroglobulin, cdx2 and p63 were negative. The proliferative activity (Mib-1/Ki-67) was low; 3-4%. In the molecular genetic study we found no mutations at position 1799 (exon 15) in the BRAF-gene, (BRAFV600E) or in exons 9 and 11 of the KIT-gene.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 98%

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Biphasic Low-Grade Nasopharyngeal Papillary Adenocarcinoma with a Prominent Spindle Cell Component: Report of a Case Localized to the Posterior Nasal Septum

Petersson

Pang

Loke³

et al. 2011

Head and Neck Pathol

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“…In fact, we found an epithelial lining layer and a subepithelial collection of lymphoid tissue typical of branchial cleft cyst, normal thyroid tissue within the cyst wall adjacent to the focus of papillary carcinoma, positive staining for thyroglobulin in tumor tissue and no evidence of papillary carcinoma in the thyroid gland when it was removed and subjected to meticulous histological examination. Considering Kreft et al's [8] article about expression of TTF-1 in metastatic papillary thyroid cancer of cystic lesions of the neck and Carrizo and Luna's [4] article about expression of TTF-1 in thyroid-like nasopharyngeal papillary adenocarcinoma, we performed TTF-1 immunostaining in primary thyroid papillary carcinoma of branchial cleft cysts to identify different staining between the two lesions. Unfortunately, a strong nuclear staining was evident in the nuclei of the lining epithelia and in the nuclei of the papillae and follicle, both in primary and metastatic thyroid papillary carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Thyroid transcription factor 1 (TTF-1) and p63 expression in two primary thyroid papillary carcinomas of branchial cleft cysts

et al. 2006

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Malignant lateral cervical cysts can be related to metastatic tumors or rarely to primary thyroid carcinoma arising in branchial cleft cysts. This study evaluates the expression of thyroid-associated transcription factor-1 (TTF-1) and p63 in three branchial cleft cysts and in two primary thyroid papillary carcinoma of branchial cleft cysts. TTF-1 was negative in the nuclei of the lining epithelia of branchial cleft cysts, but positive in the adjacent normal thyroid tissue, while TTF-1 was positive in the nuclei of the lining epithelia and in the nuclei of the papillae and follicles in branchial cleft cysts with ectopic thyroid carcinoma. P63 was positive in the nuclei of the lining epithelia of branchial cleft cysts, but negative in the adjacent normal thyroid tissue. Papillary thyroid carcinoma of branchial cleft cysts displayed p63-positive foci. In conclusion, our results demonstrate that TTF-1 cannot distinguish between primary and metastatic tumors of branchial cleft cysts. The detection of p63 in papillary thyroid carcinomas of branchial cleft cysts could suggest that p63 contributes to the onset of this tumor. It is really important to evaluate if the case has a metastatic derivation or represents papillary thyroid carcinoma arising in ectopic thyroid tissue in a branchial cleft cyst.

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“…Nasopharyngeal adenocarcinomas are classified into salivary-gland types and low-grade papillary adenocarcinoma (LGPAN) with the so-called “thyroid-like” representing a distinctive subtype of the latter 59 60 61 62…”

Section: Adenocarcinomasmentioning

confidence: 99%

Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx

Perez-Ordoñez

2009

J Clin Pathol

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Lesions of the sinonasal tract are uncommon, with most of the specimens seen by surgical pathologists consisting primarily of fragments of inflamed sinonasal mucosa or inflammatory polyps from patients with chronic rhinosinusitis, and the occasional squamous cell carcinoma. Other lesions such as hamartomas, various types of Schneiderian papillomas and adenocarcinomas are seen only rarely by most histopathologists; therefore a biopsy or surgical resection specimen from a patient with one of these processes may represent a diagnostic challenge. The aim of this review is to present the pathological features of a group of infrequent epithelial surface and glandular lesions of the sinonasal tract which includes respiratory epithelial adenomatoid hamartoma, glandular (seromucinous) hamartoma, exophytic papilloma, inverted papilloma, cylindrical cell (oncocytic) papilloma, low-grade sinonasal adenocarcinoma and intestinal-type sinonasal adenocarcinoma.

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Thyroid transcription factor–1 expression in thyroid-like nasopharyngeal papillary adenocarcinoma: report of 2 cases

Cited by 63 publications

References 16 publications

Biphasic Low-Grade Nasopharyngeal Papillary Adenocarcinoma with a Prominent Spindle Cell Component: Report of a Case Localized to the Posterior Nasal Septum

Biphasic Low-Grade Nasopharyngeal Papillary Adenocarcinoma with a Prominent Spindle Cell Component: Report of a Case Localized to the Posterior Nasal Septum

Thyroid transcription factor 1 (TTF-1) and p63 expression in two primary thyroid papillary carcinomas of branchial cleft cysts

Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx

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