Thyroid Transcription Factor-1 and Cytokeratins 7 and 20 in Pulmonary and Breast Carcinoma

Harlamert, Henry A.; Mira, Jose L.; Bejarano, P.A.; Baughman, Robert P.; Miller, Mary Ann; Whitsett, Jeffrey A.; Yassin, Rawia

doi:10.1159/000332172

Cited by 91 publications

(46 citation statements)

References 5 publications

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“…Immunohistochemical techniques provide an improved method of distinction. TTF-1 is positive in ~76% of lung adenocarcinomas and CK7 is frequently reactive in both lung and pancreatic cancers (18). In the present study, the two patients were each positive for TTF-1, but case one was positive for CK7 and case two was negative.…”

Section: Discussioncontrasting

confidence: 42%

Gastrointestinal bleeding due to pancreatic metastasis of non-small cell lung cancer: A report of two cases and a literature review

et al. 2015

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Abstract. The current study presents two cases of gastrointestinal (GI) bleeding due to pancreatic metastasis of non-small cell lung cancer (NSCLC). The two patients had a history of lung adenocarcinoma prior to pancreatic metastasis. The first patient presented with melena, epigastric pain and weight loss, and the second patient presented with melena and weight loss. The diagnoses were confirmed by biopsy of the metastatic lesions. Immunohistochemistry is useful for managing the differential diagnosis between lung cancer and pancreatic carcinoma in patients with a history of lung cancer. Chemotherapy prolonged the survival of the second patient. However, the first patient received no chemotherapy and succumbed to NSCLC six weeks after the diagnosis of metastatic pancreatic cancer. GI bleeding as a result of pancreatic metastasis of NSCLC is extremely rare; including the present two cases, only three cases have been reported in the English literature. The current study is presented in order to increase the awareness of GI hemorrhage as a manifestation of this relatively rare condition.

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Section: Discussioncontrasting

confidence: 42%

Gastrointestinal bleeding due to pancreatic metastasis of non-small cell lung cancer: A report of two cases and a literature review

et al. 2015

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“…26,[34][35][36] TTF-1, a well-characterized marker in lung and thyroid tumors, regulates SPs A, B, C, and Clara cell secretory protein. 37,38 TTF-1, by using clone 8G7G3/1, is expressed in 68-76% of lung and the TTF-1-negative lung adenocarcinomas are often poorly differentiated.…”

Section: Discussionmentioning

confidence: 99%

A study of immunohistochemical differential expression in pulmonary and mammary carcinomas

2010

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The risk of developing a second primary cancer is increased in patients with breast cancer, and the lung is one of the major sites involved. Moreover, the lung is the major metastatic site for breast cancers. A distinction between metastatic breast cancer and primary lung cancer can be histologically difficult, and both show an overlapping CK7 þ /CK20À immunoprofile in a majority of cases. The degree of difficulty increases with poorly differentiated tumors. We investigated differential expressions of TTF-1, Napsin A, surfactant apoprotein A, estrogen receptor, GATA-3, mammaglobin, and GCDFP-15 immunostains in 197 pulmonary carcinomas (158 adenocarcinomas, 39 squamous) and 115 invasive mammary carcinomas (91 ductal, 24 lobular type). In mammary carcinomas, estrogen receptor, GATA-3, mammaglobin, and GCDFP-15 were expressed in 74, 72, 64, and 62%, respectively, whereas TTF-1, Napsin A, and surfactant apoprotein A were all negative. The expressions were diffuse in estrogen receptor and GATA-3, and variable in mammaglobin and GCDFP-15. For a combination of estrogen receptor/mammaglobin or GATA-3/mammaglobin, 83% of mammary carcinomas were positive, and the detection rate was not improved by using all three markers. All lung squamous cell carcinomas were negative for all markers studied. TTF-1, Napsin A, and surfactant apoprotein A were positive in 80, 77, and 45% of pulmonary adenocarcinomas. None of the TTF-1-negative tumors expressed surfactant apoprotein A. GCDFP-15 was focally expressed in 2.5% of pulmonary adenocarcinomas, and estrogen receptor was focally expressed in one case (1.2%) of pulmonary adenocarcinoma. When metastasis from breast cancer is suspected in the lung, a combination of either estrogen receptor/mammaglobin or GATA-3/mammaglobin as breast markers, and a combination of TTF-1 and Napsin A as lung markers may be helpful for differentiating between the two. Caution should be taken in the interpretation of GCDFP-15 due to its occasional expression in pulmonary adenocarcinomas.

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“…TTF-1 is expressed in 62% to 88% of all the primary lung adenocarcinomas, but it is expressed in less than 1% of the adenocarcinomas of a non-pulmonary origin (13). Several studies have also revealed that TTF-1 was not specific for, and is rarely positive in, primary breast cancer (14). Metastatic cancer to the breast is very rare, but it is important to consider this possibility to ensure the appropriate management, and particularly in smokers with a previous diagnosis of malignancy.…”

Section: Discussionmentioning

confidence: 99%

A Case of Metachronous Metastasis to the Breast from Non-Small Cell Lung Carcinoma

et al. 2010

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I n t r o d u c t i o nNon-small cell lung cancer (NSCLC) accounts for approximately 75% to 80% of all the types of lung cancer, and it is the leading cause of cancer-related deaths worldwide (1). While small cell lung cancer can metastasize to nearly all the organs, metastasis from NSCLC is most commonly seen in the liver, adrenal glands, bone, brain, kidney and abdominal lymph nodes.Breast metastases from an extramammary primary tumor, including NSCLC, are very rarely reported, with the incidence being 0.5% to 3% of all the breast malignancies. The prognosis of these patients is poor. We report here on a case of a 42-year-old woman with metastasis to the breast from adenocarcinoma of the lung. Breast metastases from an extramammary primary tumor are very rare and the prognosis for such patients is generally poor. We report here on a case of a 42-year-old female with metastasis of non-small cell lung cancer to the breast, and she is now being followed up on an outpatient basis. In 2004, she presented with a solitary pulmonary nodule in the left lung, and this lesion had been noted to have gradually increased in size over time. The final pathological diagnosis was adenocarcinoma, and the diagnosis was made by performing percutaneous needle aspiration and lobectomy of the left upper lobe. Adjuvant chemotherapy and radiotherapy were given. Unfortunately, a nodule in the left breast was noted three years later, and metastatic non-small-cell lung cancer to the breast was diagnosed by excisional biopsy. Making the correct diagnosis to distinguish a primary breast carcinoma from a metastatic one is important, because the therapeutic plan and outcome for these two types of cancer are quite different. C a s e R e p o r t

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Thyroid Transcription Factor-1 and Cytokeratins 7 and 20 in Pulmonary and Breast Carcinoma

Cited by 91 publications

References 5 publications

Gastrointestinal bleeding due to pancreatic metastasis of non-small cell lung cancer: A report of two cases and a literature review

Gastrointestinal bleeding due to pancreatic metastasis of non-small cell lung cancer: A report of two cases and a literature review

A study of immunohistochemical differential expression in pulmonary and mammary carcinomas

A Case of Metachronous Metastasis to the Breast from Non-Small Cell Lung Carcinoma

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