Thyroid Surgery: Surgical and Metabolic Causes of Hypocalcemia

Schaefer, Steven David; Fee, Willard E.

doi:10.1001/archotol.1978.00790050029006

Cited by 1 publication

(2 citation statements)

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“…In the kidneys, PTH acts directly on proximal tubules, thereby reducing phosphorus reabsorption and increasing phosphaturia. 6 The drop in serum concentration of phosphorus in response to PTH stimulation occurs more promptly than does the increase in calcium. Therefore, monitoring of phosphorus in hypocalcemic patients who require calcium supplementation may provide an early indication of regulation of parathyroid gland function.…”

Section: Discussionmentioning

confidence: 99%

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Evolution of blood magnesium and phosphorus ion levels following thyroidectomy and correlation with total calcium values

et al. 2010

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CONTEXT AND OBJECTIVE: Magnesium ion concentration is directly related and phosphorus ion concentration is inversely related to calcemia. The aim of this study was to evaluate the evolution of magnesium and phosphorus ion levels in patients undergoing thyroidectomy and correlate these with changes to calcium concentration. DESIGN AND SETTING:Prospective study at the Alpha Institute of Gastroenterology, Hospital das Clínicas, Universidade Federal de Minas Gerais. METHODS:The study included 333 patients, of both genders and mean age 45 ± 15 years, who underwent thyroidectomy between 2000 and 2005.Total calcium, phosphorus and magnesium were measured in the blood preoperatively and 24 and 48 hours postoperatively. Ionic changes were evaluated according to the presence or absence of postoperative hypocalcemia.RESULTS: There were statistically significant drops in blood phosphorus levels 24 and 48 hours after thyroidectomy, compared with preoperative values, in the patients without hypocalcemia. In the patients who developed hypocalcemia, there was a significant drop in plasma phosphorus on the first postoperative day and an increase (also statistically significant) on the second day, in relation to preoperative phosphorus levels. A significant drop in postoperative magnesium was also observed on the first and second days after thyroidectomy in the patients with hypocalcemia, in relation to preoperative levels. In the patients without hypocalcemia, the drop in magnesium was significant on the first day, but there was no difference on the second day.CONCLUSION: Despite the postoperative changes, neither magnesium nor phosphorus ion levels had any role in post-thyroidectomy calcemia. RESUMO CONTEXTO E OBJETIVO:A concentração do íon magnésio está diretamente e a do íon fósforo inversamente relacionada à calcemia. O objetivo foi avaliar a evolução das concentrações dos íons magnésio e fósforo nos pacientes submetidos a tireoidectomia, e relacioná-los com as alterações da concentração do cálcio. TIPO DE ESTUDO E LOCAL: Estudo prospectivo realizado no Instituto Alfa de Gastroenterologia, Hospital das Clínicas, Universidade Federal de MinasGerais. MÉTODOS:O estudo incluiu 333 pacientes de ambos os sexos, com média de idade de 45 ± 15 anos, submetidos a tireoidectomia no período de 2000 a 2005. Cálcio total, fósforo e magnésio foram dosados no pré-operatório e com 24 e 48 horas de pós-operatório. As alterações dos íons foram avaliadas de acordo com a presença ou ausência de hipocalcemia pós-operatória. RESULTADOS:Houve queda estatisticamente significativa dos níveis sanguíneos de fósforo 24 horas e 48 horas após a tireoidectomia em relação ao pré-operatório nos pacientes que não tiveram hipocalcemia. Quanto aos pacientes que evoluíram com hipocalcemia, houve queda significativa do fósforo plasmático no primeiro dia de pós-operatório e elevação, também estatisticamente significativa, no segundo dia em relação ao fósforo pré-operatório. Foi também observada queda significativa do magnésio pós-operatório em relação ao p...

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Section: Discussionmentioning

confidence: 99%

“…In the kidneys, PTH acts directly on proximal tubules, thereby reducing phosphorus reabsorption and increasing phosphaturia. 6 …”

Section: Discussionmentioning

confidence: 99%