Thyroid Storm

Dumlao, Juliet S.

doi:10.1080/00325481.1974.11713820

Cited by 6 publications

(6 citation statements)

References 17 publications

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“…1 " 5 · "· 1 2 The incidence of patients progressing from thyrotoxicosis to frank thyroid storm is estimated to be 1-2 percent. 3,4 It may occur at any age and is thought to be up to nine times more common in women. 2,3 No seasonal incidence is noted.…”

Section: Plusmentioning

confidence: 99%

“…Thyroid hormones are thought to have positive chronotropic effects on the heart by direct action on mitochondrial phosphatebond synthesis in the myocardium, by stimulating the synthesis of macromolecular proteins in the myocardium, and by increasing myocardial sensitivity to endogenous catecholamines. 4 Because of these effects, cardiac output may initially be increased. However, this may lead to increased oxygen consumption by the heart, causing or exacerbating ischémie heart disease.…”

mentioning

confidence: 99%

“…Gastrointestinal (GI) symptoms, estimated to occur in 5 percent of thyroid storm patients, 4 include liver tenderness, jaundice, diarrhea, vomiting, irritable bowel syndrome, and gastric hypersécrétion.…”

mentioning

confidence: 99%

“…Although hyperpyrexia occurs in approximately 40 percent of storm patients, it is not considered to be pathognomonic for the disease. 1,4 An estimated 50 percent of thyroid storm patients have some form of cardiac involvement: most commonly sinus tachycardias, atrial fibrillation, premature ventricular contractions, congestive heart failure, or angina. Thyroid hormones are thought to have positive chronotropic effects on the heart by direct action on mitochondrial phosphatebond synthesis in the myocardium, by stimulating the synthesis of macromolecular proteins in the myocardium, and by increasing myocardial sensitivity to endogenous catecholamines.…”

mentioning

confidence: 99%

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The Pharmacotherapy of Thyroid Storm

Raber¹

1980

Drug Intelligence & Clinical Pharmacy

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A review of thyrotoxic storm is presented. Included are causes, symptomatology, and mortality rates. Special emphasis is placed on the strong correlation between adrenergic blockade and success rates in treating thyrotoxic storm. Pharmacotherapy of the acute storm patient is discussed in detail with respect to agents that (1) decrease production of thyroid hormones; (2) block release of preformed thyroid hormones from the gland; (3) blunt the effects of excess thyroid hormones on the various target organs (e.g., CNS and heart); and (4) serve to decrease the metabolic strain on all organ systems caused by thyrotoxic storm.

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Section: Plusmentioning

confidence: 99%

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confidence: 99%

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The Pharmacotherapy of Thyroid Storm

Raber¹

1980

Drug Intelligence & Clinical Pharmacy

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“…It has been shown that the rate of turnover of steroids is accelerated in hyperthyroidism [89], and that infused steroid disappears from the plasma at an increased rate in such patients [90]. A daily dose of 300 mg of hydrocortisone added to an intravenous drip is recommended [31,32,65].…”

Section: Corticosteroidsmentioning

confidence: 99%

Prevention and management of hyperthyroid storm

Dobyns

1978

World j. surg.

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Thyroid storm or crisis has become a rare clinical problem but remains a serious emergency when it occurs. The reduction in occurrence rate and deaths is not only attributable to improvements in modern management of severe hyperthyroidism, but also to the inclusion of cases in some series which, by previous standards, would not have been classified as storm in the past. Information from modern research on thyroid pathophysiology is reviewed as a basis for current steps in management of storm. Safeguards in preparation of patients with hyperthyroidism for surgery and recognition of both the potential for storm and the steps required to combat it are reviewed and emphasized.

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