Thyroid stimulation with recombinant human thyrotropin in healthy cats, cats with non-thyroidal illness and in cats with low serum thyroxin and azotaemia after treatment of hyperthyroidism

Hoek, Ingrid M. van; Vandermeulen, Eva; Peremans, Kathelijne; Daminet, Sylvie

doi:10.1016/j.jfms.2009.08.002

Cited by 13 publications

(11 citation statements)

References 31 publications

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“…Thyroid hormone replacement therapy is associated with an improvement in renal function in canine patients with primary hypothyroidism2; however, 1 small previous study reported that restoration of euthyroidism in radioiodine‐treated cats with iatrogenic hypothyroidism and azotemia did not improve GFR 3. In the present study, restoration of euthyroidism in cats with iatrogenic hypothyroidism resulted in a decrease in plasma creatinine concentrations in 18 of 19 cats, and resolution of azotemia in 50% of hypothyroid azotemic cats.…”

Section: Discussioncontrasting

confidence: 62%

“…Thyroid hormone replacement treatment is associated with an improvement in renal function in dogs with primary hypothyroidism2; however, the effect of restoration of euthyroidism on renal function in cats with iatrogenic hypothyroidism has only been investigated in 1 small previous study of cats that had been treated with radioactive iodine, which demonstrated no improvement in glomerular filtration rate (GFR) 3…”

mentioning

confidence: 99%

“…1 Thyroid hormone replacement treatment is associated with an improvement in renal function in dogs with primary hypothyroidism 2 ; however, the effect of restoration of euthyroidism on renal function in cats with iatrogenic hypothyroidism has only been investigated in 1 small previous study of cats that had been treated with radioactive iodine, which demonstrated no improvement in glomerular filtration rate (GFR). 3 The aim of the present prospective study was to investigate the effect of restoration of euthyroidism on renal function, and selected other clinicopathologic variables, in a cohort of medically treated hyperthyroid cats with iatrogenic hypothyroidism.…”

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confidence: 99%

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Effect on Renal Function of Restoration of Euthyroidism in Hyperthyroid Cats with Iatrogenic Hypothyroidism

Williams

Elliott

Syme

2014

Veterinary Internal Medicne

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BackgroundIatrogenic hypothyroidism is associated with an increased incidence of azotemia after treatment of hyperthyroidism, and decreased survival time in azotemic hyperthyroid cats.HypothesisRestoration of euthyroidism will decrease plasma creatinine concentrations.AnimalsNineteen client‐owned, methimazole‐ or carbimazole‐treated, hyperthyroid cats with documented iatrogenic hypothyroidism (based on subnormal plasma total thyroxine concentrations [TT4] and increased plasma thyroid‐stimulating hormone concentrations).MethodsProspective interventional study. Doses of antithyroid medication were reduced until euthyroidism was restored (TT4 10–40 nmol/L). Plasma creatinine concentration and selected other clinicopathologic variables were evaluated before and after restoration of euthyroidism and compared by nonparametric statistics. Data are presented as median [25th, 75th percentile].ResultsRestoration of euthyroidism was associated with a significant decrease in plasma creatinine concentrations (2.61 [1.90, 3.26] mg/dL versus 2.07 [1.42, 2.82] mg/dL; P < .001) and body weight (4.03 [3.59, 4.53] kg versus 3.89 [3.34, 4.18] kg; P = .019), and a significant increase in packed cell volume (30 [28, 39]% versus 34 [29, 39]%; P = .038), heart rate (174 [163, 201] bpm versus 190 [164, 202] bpm; P = .009), and plasma alkaline phosphatase activity (26.6 [17.0, 33.0] IU/L versus 38.0 [23.5, 46.5] IU/L; P < .001).Conclusions and Clinical ImportanceRestoration of euthyroidism in medically treated hyperthyroid cats with iatrogenic hypothyroidism causes a reduction in plasma creatinine concentrations, and thus might improve renal function; however, this could be influenced by concurrent changes in body weight.

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Section: Discussioncontrasting

confidence: 62%

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confidence: 99%

mentioning

confidence: 99%

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Effect on Renal Function of Restoration of Euthyroidism in Hyperthyroid Cats with Iatrogenic Hypothyroidism

Williams

Elliott

Syme

2014

Veterinary Internal Medicne

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“…The indications, protocol, and interpretation of the TSH stimulation test are similar for the cat and dog except that a lower dose of recombinant human thyrotropin (rhTSH) (25 micrograms IV) is used in the cat (Stegeman et al, 2003;van Hoek et al, 2010). In euthyroid cats, there is a two-to threefold increase in total T 4 6 to 8 hours after TSH administration.…”

Section: Thyroid-stimulating Hormone Stimulation Testmentioning

confidence: 99%

Hypothyroidism

Scott‐Moncrieff¹

2015

Canine and Feline Endocrinology

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“…A thyroid panel including T4 and TSH, preferably supplemented by free T4 and T3, in combination with typical clinical signs is required to diagnose feline hypothyroidism. A thyrotropin releasing hormone (TRH)-or TSH-stimulation test can also be performed to confirm the diagnosis [37]. In the present case a TSH-stimulation test was not performed, because the clinical and radiographic findings in combination with a low T4 value and a high TSH were regarded as an adequate basis to diagnose the disease.…”

Section: Discussionmentioning

confidence: 94%

Bilateral femoral capital physeal fractures in an adult cat with suspected congenital primary hypothyroidism

Diehm

Dening

Dziallas

et al. 2019

Tierarztl Prax Ausg K

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A 4-year-old, neutered male European shorthair was presented for evaluation of right hind limb lameness. Radiographs revealed bilateral femoral capital physeal fractures, widened vertebral growth plates and constipation. Physical findings included lethargy, mental dullness, mild hypothermia, retarded growth, pharyngeal stridor, moderate muscle atrophy of pelvic limbs, hair coat abnormalities, and lack of defecation and urination. A thyroid panel revealed thyroid hormone values below detection limits and high thyroid stimulation hormone values. A presumptive diagnosis of congenital primary hypothyroidism was made, however also an early onset acquired primary hypothyroidism could not be ruled out. Results of the insulin-like growth factor (IGF-1) and the parathyroid hormone as well as an adrenocorticotropic hormone stimulating test were normal. A bilateral femoral head and neck excision was performed. Levothyroxine supplementation was started at a dosage of 50 µg (11 µg/kg) BID and later adjusted to 100 µg (22 µg/kg) BID based on total thyroxine concentrations. The tomcat showed full clinical recovery and normal clinical behaviour. The case shows that primary hypothyroidism may be considered in cats presented with femoral capital physeal fractures.

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Thyroid stimulation with recombinant human thyrotropin in healthy cats, cats with non-thyroidal illness and in cats with low serum thyroxin and azotaemia after treatment of hyperthyroidism

Cited by 13 publications

References 31 publications

Effect on Renal Function of Restoration of Euthyroidism in Hyperthyroid Cats with Iatrogenic Hypothyroidism

Effect on Renal Function of Restoration of Euthyroidism in Hyperthyroid Cats with Iatrogenic Hypothyroidism

Hypothyroidism

Bilateral femoral capital physeal fractures in an adult cat with suspected congenital primary hypothyroidism

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