Thyroid Stimulating Hormone values from cord blood in neonates

Mekonnen, Yalemtsehay; Hawariat, Gizachew W.; Chamiso, Bekele; Raue, Friedhelm

doi:10.4314/ejhd.v17i2.9853

Cited by 9 publications

(9 citation statements)

References 16 publications

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“…Our result is consistent with the mean TSH value of the previous studies conducted by Singh et al -8.833 ± 7.059 µIU/mL (11) and Mekonen Y et al 9.6 ± 5.27 µIU/mL. (12) In our study, we observed a decreasing trend of mean TSH when the gestational age increases. The mean value of CB TSH was significantly higher in 28 -31 weeks compared to 32 -33 weeks, 34 -36 weeks and 37 -42 weeks (p= 0.001).…”

Section: Discussionsupporting

confidence: 93%

Maternal and Perinatal Factors Affecting Cord Blood Thyroid Stimulating Hormone Level

P¹,

Vazhayil²,

Balusamy³

2018

jemds

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BACKGROUND Incidence of Congenital Hypothyroidism in India is relatively high when compared to that of other parts of the world. The fact that only 5-10% can be diagnosed clinically signifies the role of screening program for early diagnosis and early initiation of therapy to treat this preventable cause of intellectual disability. Cord blood TSH (CB TSH) estimation has high sensitivity, but various maternal and perinatal factors affect the CB TSH levels, which may interfere with the interpretation. This study was done to find out the various maternal and perinatal factors affecting CB TSH level. MATERIALS AND METHODS A hospital-based cross-sectional study was conducted in the Department of Neonatology, Govt. Medical College, Ernakulam over a period of one year from February 2016 to January 2017. We enrolled 127 live neonates selected by systematic random sampling method. Cord blood TSH level was estimated and the results were statistically analysed with respect to various maternal and perinatal factors. RESULTS Mean CB TSH in the study population was 9.713 ± 7.286. The risk factors for a significantly high CB TSH level were low Apgar at 1 minute, Preterm babies and Primigravida mothers (p < 0.05). A significantly low CB TSH was noted in preterm neonates who received antenatal steroids (p < 0.05). The other factors like gestational diabetes, gestational hypertension, gender of the baby, birth weight and meconium stained liquor were found to have no significant relationship with the CB TSH level. CONCLUSION Mainly low Apgar at 1 min which is an indicator of foetal distress/ perinatal asphyxia, prematurity and parity contributed to the significant elevation of CB TSH level. Antenatal steroids can significantly blunt the TSH surge. Due consideration should be given to these factors while interpreting CB TSH levels.

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Section: Discussionsupporting

confidence: 93%

Maternal and Perinatal Factors Affecting Cord Blood Thyroid Stimulating Hormone Level

P¹,

Vazhayil²,

Balusamy³

2018

jemds

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“…This can be explained by the difference in method of analysis. Immunoradiometric assay was used in the previous study which had low sensitivity as 16.1 % of males and 30.5 % of females were reported for undetected results [ 8 ] whereas the lowest values was 2.40 mIU/L in the present study using the Electrochemiluminescence Immunoassay Method. Other possible explanations were the previous study includes all the preterm and full term infants which can lower the cut-off values of TSH.…”

Section: Discussionmentioning

confidence: 61%

“…Previously, few studies have reported in establishing cutoff values of cord blood TSH in Ethiopia. One study from yalemtsehay and co-workers was performed, at the same study area with the current study, and they determined the cutoff value of cord blood TSH (the 97.8 th percentile in this case) was 15.4 mIU/L [ 8 ]. Another study, which was not on the cord blood sample, had measured TSH values of blood from a heel-pricks in neonates from six hours of life up to seven days old infants.…”

Section: Discussionmentioning

confidence: 99%

“…Specimens from cord blood and filter paper spotted with blood from a heel break can be utilized to measure TSH and fT4 for Congenital hypothyroidism screening. Due to early discharges from hospitals in Ethiopia, it is usually difficult to take blood samples from neonates after a few days of life [ 8 ]. Therefore, cord blood is the specimen of choice as it is readily available at birth, with adequate volume for supplemental tests when required.…”

Section: Introductionmentioning

confidence: 99%

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Establishment of reference intervals of thyroid function tests from cord blood of neonates in two selected hospitals, Addis Ababa, Ethiopia

et al. 2016

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BackgroundReference intervals are affected by different factors such as lifestyle, ethnicity, age/developmental stage, gender, nutrition and other environmental factors (Clin Biochem Rev: 29,2008). Therefore, it is obvious that it should be established for every population in different regions even within a country. Then the aim of this study is to establish population specific reference intervals of thyroid stimulating hormone, free thyroxine and free triidothyronine levels of cord blood.ResultsOne hundred twenty three cord blood samples collected from the umbilical cord of newborns were analyzed for thyroid stimulating hormone, free thyroxine and free triidothyronine values. The birth weights ranged between 2500 and 4700 g with mean (SD) value of 3241.46 (459.495) gram. Their gestational age ranged between 37 and 44 weeks with an average of 39.74 weeks. The 2.5th and 97.5th percentiles of values were found to be 3.48 mIU/L and 27.57 mIU/L for thyroid stimulating hormone, 0.89 ng/dl and 1.53 ng/dl for free thyroxine and 1.19 pg/ml and 2.51 pg/ml for free triidothyronine respectively.ConclusionIn the present study the reference intervals of thyroid stimulating hormone, free thyroxine and free triidothyronine were established and based on the results obtained, were 3.48–27.56 mIU/L for thyroid stimulating hormone, 0.89–1.53 ng/dl for free thyroxine and 1.19–2.51 pg/ml for free triidothyronine. It has been concluded that the result can provide us with an important baseline to establish population specific reference intervals for our country using large scale studies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12887-016-0654-2) contains supplementary material, which is available to authorized users.

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“…Earlier studies reported an Incidence of NH as 3:1207 (Ethiopia), 1:1446 (Italy), 1:1667 and 1:3670 (Latin America), and 1:4000 (United States), respectively. [ 104 105 106 107 ] Newborn screening in Brazil had revealed consistent lowering in the incidence of NH in 3 consecutive years (1:3616 in 2005, 1:1369 in 2006 and 1:1030 in 2007). [ 108 ] Thus, this high prevalence of NH is indicative of widespread IDD throughout the globe at different intensities.…”

Section: R Esultsmentioning

confidence: 99%

Need for neonatal screening program in India: A national priority

Sareen

Pradhan²

2015

Indian J Endocr Metab

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In India, out of 342 districts surveyed, 286 have been identified as endemic to iodine deficiency (ID). Research studies conducted in school age children (SAC), Adolescent girls, Pregnant Mothers (PMs) and Neonates have documented poor iodine nutritional status. As observed by total goiter rate of more than 5% and median urinary iodine concentration level of <100 μg/l in SAC and <150 μg/l in PMs as prescribed cutoff of World Health Organization. And higher thyroid stimulating hormone levels among neonates. ID leads to compromised mental development and hence which remain hidden and not visible to family, program managers and administrator. The present review describes the current status of ID in different parts of the country. With a view to strongly recommend the implementation of Neonatal screening program for ID so that the optimal mental development of children can be achieved.

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Thyroid Stimulating Hormone values from cord blood in neonates

Cited by 9 publications

References 16 publications

Maternal and Perinatal Factors Affecting Cord Blood Thyroid Stimulating Hormone Level

Maternal and Perinatal Factors Affecting Cord Blood Thyroid Stimulating Hormone Level

Establishment of reference intervals of thyroid function tests from cord blood of neonates in two selected hospitals, Addis Ababa, Ethiopia

Need for neonatal screening program in India: A national priority

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