Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology

Aghajanova, Lusine; Stavréus-Evers, Anneli; Lindeberg, Maria; Landgren, Britt-Marie; Sparre, Lottie Skjöldebrand; Hovatta, Outi

doi:10.1016/j.fertnstert.2010.06.079

Cited by 107 publications

(119 citation statements)

References 38 publications

(43 reference statements)

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…Particularly, these receptors were abundant in the stroma. These results resemble those observed in the ovary of humans and rats (15)(16)(17)(18). The presence of TRs and TSHR in the corpus albicans and hemorrhagic cysts of rabbits contrasts with that found in cows (19).…”

Section: Discussionsupporting

confidence: 78%

“…A strong immunostaining anti-TSHR, -TRα1, and -TRß1 has been observed in the ovarian surface epithelium and in primordial, primary and secondary follicles (15)(16)(17). Additionally, the corpus luteum of rats has TRα1-2 and TRß1 (18). The corpus luteum of cows, but not the corpus hemorrhagic or the corpus albicans, shows immunolabeling for TSHR (19).…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 97%

Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The finding that donor TSH level, independent of recipient TSH level, was associated with recipient clinical pregnancy implies that thyroid function may impact the likelihood of pregnancy prior to fertilization and implantation. Although there are data implicating thyroid hormones as key mediators in folliculogenesis and endometrial receptivity [2,3,12,13], clinical studies that do not utilize a donor model largely cannot differentiate between the potential impacts on donor versus host when evaluating overall pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…The pivotal role which thyroid function plays in several aspects of female reproduction has been well documented by several investigators [1][2][3]. Given its relevance to reproduction and pregnancy, women with infertility are routinely screened for thyroid function with serum thyroid-stimulating hormone (TSH) prior to elective fertility treatment [4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Donor TSH level is associated with clinical pregnancy among oocyte donation cycles

Karmon

Cardozo

Souter

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The purpose of the study is to evaluate the association between donor TSH level (independent of recipient TSH level) and recipient pregnancy outcome among fresh donor oocyte IVF cycles. Methods This is a retrospective cohort study investigating 232 consecutive fresh donor-recipient cycles (200 total oocyte donors) at an academic medical center. Main outcome measures include clinical pregnancy and live birth. Results Cycles were categorized into two groups based on donor TSH level (< 2.5 and ≥ 2.5 mIU/L). After controlling for multiple donor and recipient characteristics, the probability of clinical pregnancy was significantly lower among donors with TSH levels ≥2.5 mIU/L compared to those with TSH values <2.5 mIU/L (43.1 %, 95 % CI 28.5-58.9, versus 66.7 %, 95 % CI 58.6-73.9, respectively, p = 0.01). The difference in live birth rates between the two groups did not achieve statistical significance (43.1 %, versus 58.0 %,, respectively, p = 0.09). Conclusions Donor TSH level, independent of recipient TSH level, is associated with recipient clinical pregnancy. These findings suggest that thyroid function may impact the likelihood of pregnancy at the level of the oocyte.

show abstract

Expression of proteins related to thyroid hormone function in the uterus is down‐regulated at the day of implantation in hypothyroid pregnant rats

Salleh

Sayem

Giribabu

et al. 2019

Cell Biology International

View full text Add to dashboard Cite

Hypothyroidism has been linked to infertility, but the mechanisms underlying infertility-related hypothyroidism have yet to be fully elucidated. Therefore, in this study, effects of hypothyroidism on expression of the proteins related to thyroid hormone function in the uterus, which were thought to play a role implantation, including thyroid hormone receptor (TR), thyroid stimulating hormone receptor (TSHR), retinoic acid receptor (RAR) and extracellular kinase (ERK) were identified. Pregnant female rats were rendered hypothyroid by giving methimazole (MMI), orally. Following hypothyroid induction, rats were grouped into control (non-treated) and received subcutaneous thyroxine at 20, 40, and 80 mg/kg/day for five consecutive days. At Day 6, which is the day of implantation (GD 6), rats were sacrificed and the number of embryo implantation site in the uterus was calculated. Then, uterine horns were harvested and expression of the above proteins and their mRNAs were identified by Western blotting and real-time PCR, respectively. In non-treated hypothyroid pregnant rats, the number of embryo implantation sites decreased as compared to euthyroid and hypothyroid rats receiving thyroxine treatment. Similarly, expression of TRa-1, TRb-1, TSHR, ERK1/2 and RAR proteins and mRNA in the uterus of non-treated hypothyroid rats also decreased (P < 0.05 when compared to euthyroid and thyroxine-treated hypothyroid rats). In conclusion, downregulated expression of the thyroid hormone related proteins in the uterus at the day of implantation might result in infertility as reported in hypothyroid condition.

show abstract

Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology

Cited by 107 publications

References 38 publications

Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

Donor TSH level is associated with clinical pregnancy among oocyte donation cycles

Expression of proteins related to thyroid hormone function in the uterus is down‐regulated at the day of implantation in hypothyroid pregnant rats

Contact Info

Product

Resources

About