Thyroid-stimulating hormone levels in euthyroid patients 8 years following bariatric surgery

Lautenbach, Anne; Wernecke, Marie; Mann, Oliver; Busch, Philipp; Huber, Tobias B.; Stoll, Fabian; Aberle, Jens

doi:10.1038/s41366-021-01058-z

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Thus, bariatric surgery, specifically procedures associated with fundoplication that result in lower ghrelin levels, may have an additive effect in improving thyroid function. 19,20 Vitamin D: The results in Figure 1 and Table 1 showed a significant decrease in vitamin D levels at a probability level (P ≤ 0.05) in the serum of patients who underwent sleeve gastrectomy and in all specified time periods compared with the same group of patients. Before the operation, the largest decrease was recorded three months after the operation compared to one month.…”

Section: Resultsmentioning

confidence: 96%

Effects of Sleeve Gastrectomy on Thyrotropin Hormone (TSH) and Vitamin D Levels among Obese Patients in Nineveh Governorate

Ibrahim,

Bdaiwi,

Al Sherbit

et al. 2023

J. Contemp. Med. Sci.

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Objectives: This study aimed to assess the impact of bariatric surgery on thyrotropin (TSH), calcium, vitamin D, and lipid profile levels three months post-surgery among patients who underwent the procedure. We also investigated the prevalence of micronutrient deficiencies during the initial three months before and after surgery, along with monitoring the effects of gastric sleeve surgery on body mass index (BMI) reduction. Methods: The study involved the analysis of data from a cohort comprising 30 patients of both genders who had undergone sleeve gastrectomy due to obesity, with a preoperative BMI of 40 kg/m² or higher. The research spanned from July 2022 to January 2023, with patients undergoing gastric sleeve surgery at Al-Zahrawi Hospital in Nineveh. These patients were subsequently followed up for a period of three months post-surgery. Results: The study findings demonstrated a significant reduction in TSH, vitamin D, calcium, total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDLc), very low-density lipoproteins (VLDLc) cholesterol, and BMI in patients who underwent gastric sleeve surgery within the three-month follow-up period, in comparison to their pre-surgery levels. Additionally, there was a noteworthy increase in high-density lipoproteins of cholesterol (HDLc) in the serum of these patients post-operation. The results further indicated positive correlations between TSH, vitamin D, cholesterol, LDLc, and the Atherogenic Index. Likewise, positive correlations were observed between vitamin D, TSH, total cholesterol, triglycerides (TG), and LDLc. Conclusion: Post-surgery deficiencies in vitamin D, calcium, and TSH levels are attributed to inadequate intake and absorption of micronutrients, highlighting the importance of nutritional supplementation. Sleeve gastrectomy offers a promising avenue for sustained BMI reduction in the long term.

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Section: Resultsmentioning

confidence: 96%

Effects of Sleeve Gastrectomy on Thyrotropin Hormone (TSH) and Vitamin D Levels among Obese Patients in Nineveh Governorate

Ibrahim,

Bdaiwi,

Al Sherbit

et al. 2023

J. Contemp. Med. Sci.

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Alterations in Thyroid Hormones in Obese Patients Are Associated With Body Composition Changes After Bariatric Surgery

Yan,

Chu,

Wang

et al. 2024

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context This article mainly explored the relationship between body composition and thyroid function in euthyroid obesity through correlation analysis, which showed the significant changes of thyroid function after bariatric surgery notably correlated with changes in body composition. Objective This study investigates how metabolic/bariatric surgery (MBS) affects thyroid hormone (TH) levels and TH resistance in obese euthyroid individuals, focusing on their correlation with changes in body composition. Methods We included 470 obese individuals and 118 controls for baseline assessment, and 125 obese patients receiving MBS for longitudinal study. Data on body composition and thyroid function were collected. Correlations between baseline and changes in thyroid function and body composition were assessed. Results In the obese group, thyrotropin (TSH), free triiodothyronine (fT3) levels, and thyroid feedback quantile-based index (TFQI) were elevated and significantly decreased post MBS, along with visceral fat area (VFA) and body fat percentages, whereas skeletal muscle mass (SMM) percentage increased. Preoperative partial correlation analysis adjusted for age and sex revealed that TSH positively correlated with VFA (r = 0.109; P = .019), body fat percentage (r = 0.114; P = .013), and negatively correlated with SMM percentage (r = −0.104; P = .024). Similar correlations were observed between central TH resistance indices and body composition, but no statistically significant correlations were found in the control group. Post MBS, decreased TSH positively correlated with decreased VFA (r = 0.251; P = .006) and increased SMM percentage (r = 0.233; P = .011). While reductions in VFA and body fat percentage were linked to improved central TH resistance, a decrease in peripheral TH conversion was noted. Conclusion MBS significantly affects thyroid function and TH resistance, with notable correlations to changes in body composition.

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Is there a link between obesity phenotype and thyroid diseases? A mini-review of current concepts

Milewska-Kobos,

Szczepanek-Parulska,

Ruchala

2023

Postępy Higieny I Medycyny Doświadczalnej

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Obesity is a chronic, relapsing, and progressive disease that leads to negative health consequences. Excessive adiposity frequently coexists with metabolic and nonmetabolic complications, deteriorating health and reducing quality of life and life span. Individuals with obesity are not a homogenous group and can present different obesity phenotypes. The most common obesity phenotypes include: metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO). The latter category involves those with developed metabolic syndrome (MetS) and non-fully-developed metabolic syndrome (pre-MetS). The fundamental factor leading to obesity is imbalance between energy uptake and expenditure. From this perspective the thyroid gland plays the pivotal role in metabolism regulation and obesity development. The thyroid regulates thermogenesis, appetite, and lipids turnover. Clinically, hypothyroid patients have decreased metabolic rate and subsequently experience increase of BMI and excess adiposity. The interaction between the thyroid gland and obesity is bidirectional. Several mechanisms of alteration of the hypothalamus-pituitary-thyroid axis in obesity are proposed. Excessive adiposity and dysfunction of adipose tissue may contribute to the development of thyroid functional and structural impairment, such as autoimmunity, thyroid nodules, and thyroid cancer. The prevalence of certain thyroid disorders in obese individuals is higher than in nonobese subjects and this trend is more pronounced in unhealthy obesity phenotypes. The aim of this mini-review is to present the current knowledge on the interaction between thyroid gland disorders and obesity, with special focus on obesity phenotypes.

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Thyroid-stimulating hormone levels in euthyroid patients 8 years following bariatric surgery

Cited by 3 publications

References 38 publications

Effects of Sleeve Gastrectomy on Thyrotropin Hormone (TSH) and Vitamin D Levels among Obese Patients in Nineveh Governorate

Effects of Sleeve Gastrectomy on Thyrotropin Hormone (TSH) and Vitamin D Levels among Obese Patients in Nineveh Governorate

Alterations in Thyroid Hormones in Obese Patients Are Associated With Body Composition Changes After Bariatric Surgery

Is there a link between obesity phenotype and thyroid diseases? A mini-review of current concepts

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