Thyroid-stimulating hormone improves insulin sensitivity in skeletal muscle cells via cAMP/PKA/CREB pathway-dependent upregulation of insulin receptor substrate-1 expression

Moon, Min Kyong; Kang, Geun Hyung; Kim, Hwan Hee; Han, Sun Kyoung; Koo, Young Do; Cho, Sun Wook; Kim, Ye An; Oh, Byung‐Chul; Park, Do Joon; Chung, Sung Soo; Park, Kyong Soo; Park, Young Joo

doi:10.1016/j.mce.2016.07.018

Cited by 23 publications

(11 citation statements)

References 24 publications

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“…[30] TSH improves insulin sensitivity in skeletal muscle by increasing insulin receptor substrate (Irs)-1 gene expression, and this regulatory effect is mediated by a protein kinase A-cAMP response element binding protein (PKA-CREB) dependent pathway. [31] Our study showed that the positive relationship between TSH levels and PTC disappeared after adjusting age, gender, FBG levels, maximal nodule diameter and multifocality. Hence, we suggested that higher TSH level is related, but not independently, to the risk of PTC.…”

Section: Zhao Et Al Medicine (2019) 98:50mentioning

confidence: 47%

Association of obesity with the clinicopathological features of thyroid cancer in a large, operative population

Zhao¹,

Jia²,

Fan³

et al. 2019

Medicine

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We aimed to investigate the association between excess body mass index (BMI) and papillary thyroid cancer (PTC) in an operative population, and the impact of higher BMI on clinicopathological aggressiveness of PTC.Charts of 10,844 consecutive patients with thyroid nodules undergoing partial or total thyroidectomy between 1993 and 2015 were reviewed. Patients diagnosed with PTC were stratified in 4 groups: BMI < 18.5 (underweight), 18.5 BMI < 24 (normal-weight), 24 BMI < 28 (overweight) and BMI ≥ 28(obese). The impacts of high BMI on prevalence and clinicopathological parameters of PTC were retrospectively analyzed in both univariate and multivariate binary logistic regression analysis.For every 5-unit increase in body mass, the odds of risk-adjusted malignance increased by 36.6%. The individuals who were obese and overweight were associated with high risk of thyroid cancer [odds ratio (OR)= 1.982, P < .001; OR= 1.377, P < .001; respectively] compared to normal weight patients, and this positive association was found in both genders. Obesity was independent predictors for tumors larger than 1 cm (OR = 1.562, P < .001) and multifocality (OR = 1.616, P < .001). However, there was no difference in cervical lymph node (LN) metastasis among BMI groups. Crude analysis showed BMI was associated with advanced tumor-node-metastasis (TNM) stage (relative risk, approximately 1.23 per 5 BMI units, P < .001), but this association disappeared after adjusting for confounding factors.Obesity was significantly associated with the risk of PTC in a large, operative population. Higher BMI was significantly associated with larger tumor size and multifocal tumor.Abbreviations: BMI = body mass index, FBG = fasting blood glucose, FNAB = fine needle aspiration biopsy, IGF-1 = insulin-like growth factor-1, LN = lymph node, OR = odds ratio, PTC = papillary thyroid cancer, TNM = tumor-node-metastasis.

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Section: Zhao Et Al Medicine (2019) 98:50mentioning

confidence: 47%

Association of obesity with the clinicopathological features of thyroid cancer in a large, operative population

Zhao¹,

Jia²,

Fan³

et al. 2019

Medicine

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“…Further validation by qRT-PCR confirmed the sequencing results. Of note, the main predicted target genes of the differentially expressed ncRNAs were linked to molecular pathways known to critically regulate glycolipid metabolism and β-cell function, such as the sphingolipid [86], the Notch [87], the thyroid hormone receptor [88] and the prolactin signaling pathways [89]. In particular, the sphingolipid signaling pathway is involved in the development of lipotoxicity [86], regulating ceramide metabolism in peripheral tissues (skeletal muscle, liver and adipose tissue) and in pancreatic β-cells.…”

Section: β-Cell Dysfunctionmentioning

confidence: 99%

Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications

Filardi

Catanzaro

Mardente

et al. 2020

IJMS

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Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance that develops in the second or third trimester of pregnancy. GDM can lead to short-term and long-term complications both in the mother and in the offspring. Diagnosing and treating this condition is therefore of great importance to avoid poor pregnancy outcomes. There is increasing interest in finding new markers with potential diagnostic, prognostic and therapeutic utility in GDM. Non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs and circular RNAs, are critically involved in metabolic processes and their dysregulated expression has been reported in several pathological contexts. The aberrant expression of several circulating or placenta-related ncRNAs has been linked to insulin resistance and β-cell dysfunction, the key pathophysiological features of GDM. Furthermore, significant associations between altered ncRNA profiles and GDM-related complications, such as macrosomia or trophoblast dysfunction, have been observed. Remarkably, the deregulation of ncRNAs, which might be linked to a detrimental intrauterine environment, can lead to changes in the expression of target genes in the offspring, possibly contributing to the development of long-term GDM-related complications, such as metabolic and cardiovascular diseases. In this review, all the recent findings on ncRNAs and GDM are summarized, particularly focusing on the molecular aspects and the pathophysiological implications of this complex relationship.

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“…The Notch signaling pathway was associated with the regulation of physiological insulin 33 . Thyroid hormone 34 and Hedgehog signaling pathways 35 have also been found to be involved in the improvement of insulin sensitivity in skeletal muscle and insulin resistance in adipose tissue. Genes encoding cell cycle regulators influenced gestational glucose tolerance and regulation 36 .…”

Section: Discussionmentioning

confidence: 99%

Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus

Tang

2020

J of Diabetes Invest

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Aims/Introduction Non‐coding ribonucleic acids (ncRNAs) have recently been shown to be involved in various biological processes. However, most of these ncRNAs are of unknown function or without annotation. This study first investigated the whole transcriptome profiles of placentas to identify the potential functions that ncRNAs exerted in gestational diabetes mellitus (GDM). Materials and Methods Six placenta samples from healthy pregnant women (n = 3) and GDM (n = 3) were collected to analyze the whole transcriptome profiles by high‐throughput sequencing. Differentially expressed ncRNAs were further validated by quantitative real‐time polymerase chain reaction on an independent set of normal (n = 20) and GDM (n = 20) placenta samples. Results A total of 2,817 microRNAs (miRNAs), 23,339 long non‐coding RNAs (lncRNAs) and 9,513 circular RNAs (circRNAs) were identified. There were 290 differentially expressed ncRNAs in GDM placentas compared with the placentas of healthy pregnant women. Two miRNAs, 86 lncRNAs and 55 circRNAs were upregulated, while two miRNAs, 86 lncRNAs and 59 circRNAs were downregulated in GDM. The expression of the selected ncRNAs, which were further validated by quantitative real‐time polymerase chain reaction, was consistent with the sequencing results. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that the major targets of these ncRNAs were associated with insulin resistance, and abnormal glucose and lipid metabolism. A GDM‐related competing endogenous RNA network suggested the interactions between lncRNAs, circRNAs, messenger RNAs and miRNAs. Conclusions The whole transcriptome profiles significantly differed in GDM placentas compared with the placentas of healthy pregnant women, which might be valuable for detecting novel ncRNAs, and providing new research insights into exploring the pathogenic mechanisms of GDM.

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Thyroid-stimulating hormone improves insulin sensitivity in skeletal muscle cells via cAMP/PKA/CREB pathway-dependent upregulation of insulin receptor substrate-1 expression

Cited by 23 publications

References 24 publications

Association of obesity with the clinicopathological features of thyroid cancer in a large, operative population

Association of obesity with the clinicopathological features of thyroid cancer in a large, operative population

Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications

Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus

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