Thyroid Status, Cardiac Function, and Mortality in Patients With Idiopathic Dilated Cardiomyopathy

Wang, Wenyao; Guan, Haixia; Gerdes, A. Martin; Iervasi, Giorgio; Yang, Yuejin; Tang, Yi-Da

doi:10.1210/jc.2014-4159

Cited by 52 publications

(38 citation statements)

References 38 publications

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“…In this subclinical hyperthyroid group, the percentage of LGE-positive segments was significantly lower. This finding corresponds to an interesting result of our previous study in which the prevalence of atrial fibrillation was unexpectedly lower in the subclinical hyperthyroid group than in other thyroid states4. At that time, a possible explanation was given that usage of beta-blockers in our cohort was more frequent, thus blunting the potential pathophysiological effects of subclinical hyperthyroidism.…”

Section: Discussionsupporting

confidence: 89%

“…This subgroup belongs to a cohort study of 458 IDCM patients previously reported4. The study disposition is showed in Supplementary Figure S1.…”

Section: Methodsmentioning

confidence: 99%

“…Our previous study4, together with other clinical evidence56, suggests that thyroid hormone (TH) levels correlate with cardiac function and hypothyroidism was a predictor of poor outcome in dilated cardiomyopathy (DCM). However, detailed understanding of mechanisms linking thyroid dysfunction and heart failure (HF) are warranted to support further studies on treatment.…”

mentioning

confidence: 95%

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Free Triiodothyronine Level Correlates with Myocardial Injury and Prognosis in Idiopathic Dilated Cardiomyopathy: Evidence from Cardiac MRI and SPECT/PET Imaging

Wang

Guan

Fang

et al. 2016

Sci Rep

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Thyroid dysfunction is associated with poor prognosis in heart failure, but theories of mechanisms are mainly based on animal experiments, not on human level. We aimed to explore the relation between thyroid function and myocardial injuries in idiopathic dilated cardiomyopathy (IDCM) using cardiac magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Myocardial fibrosis was detected by late gadolinium enhancement (LGE) MRI, and myocardial perfusion/metabolism was evaluated by 99mTc-MIBI SPECT /18F-FDG PET imaging. Across the quartiles of FT3, decreased percentage of segments with LGE and perfusion/metabolism abnormalities were found. As for FT4 and TSH levels, no significant distribution trend of myocardial injuries could be detected. In logistic analysis, FT3 was independently associated with the presence of LGE (OR: 0.140, 95% CI: 0.035–0.567), perfusion abnormalities (OR: 0.172, 95% CI: 0.040–0.738) and metabolism abnormalities (OR: 0.281, 95% CI: 0.081–0.971). After a median follow-up of 46 months, LGE-positive and FT3 < 2.77 pg/mL was identified as the strongest predictor of cardiac events (HR: 8.623, 95% CI: 3.626–16.438). Low FT3 level is associated with myocardial fibrosis and perfusion/metabolism abnormalities in patients with IDCM. The combination of FT3 level and LGE provides useful information for assessing the prognosis of IDCM.

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Section: Discussionsupporting

confidence: 89%

“…This subgroup belongs to a cohort study of 458 IDCM patients previously reported4. The study disposition is showed in Supplementary Figure S1.…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 95%

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Free Triiodothyronine Level Correlates with Myocardial Injury and Prognosis in Idiopathic Dilated Cardiomyopathy: Evidence from Cardiac MRI and SPECT/PET Imaging

Wang

Guan

Fang

et al. 2016

Sci Rep

Self Cite

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“…This correlation though did not exist with levels of T4 or TSH. At the clinical level there is correlation between low levels of T3 and idiopathic dilated cardiomyopathy [12]. …”

Section: Geneticsmentioning

confidence: 99%

Sub-Clinical Hypothyroidism and Its Association With Increased Cardiovascular Mortality: Call For Action!

et al. 2017

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Thyroid hormones play an important role in regulating different functions regarding metabolism and performance in multiple organs. Any change in the thyroid hormones axis can lead to profound effect on the vital organ stability especially the cardiovascular system. Hypothyroidism is classified according to the clinical presentation as overt and subclinical. Currently, there exists a paucity of evidence on the beneficial effects of thyroxine hormone replacement on cardiovascular mortality outcomes in subclinical hypothyroidism. Also, the clinical relevance of measuring and treating supra-normal thyroid-stimulating hormone levels in newly diagnosed heart failure patients with preserved ejection fraction requires further study. Here we review the current evidence regarding the prognostic significance of sub-clinical hypothyroidism in patients with heart failure with preserved ejection fraction.

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“…But more importantly, some studies suggest that more than 90% of patients with overt hypothyroidism and some patients with subclinical hypothyroidism can have derangements of the lipid profile, including low density lipoproteins (LDL) and apolipoprotein A. Treatment with thyroid hormones can lead to reversal of these derangements [10]. …”

Section: Geneticsmentioning

confidence: 99%

Subclinical Hypothyroidism and Its Association with Increased Cardiovascular Mortality

Ufion

Zulfiqar

Hassan

et al. 2017

Cardiology Research and Practice

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Thyroid hormones play an important role in regulating different metabolism functions and multiple organs' performance. Changes in the thyroid hormone axis can lead to profound effects on the stability of vital organs and systems, especially the cardiovascular system. Hypothyroidism is classified according to the clinical presentation as overt and subclinical. There is some evidence supporting the benefits of thyroxine hormone replacement for subclinical hypothyroidism on cardiovascular mortality outcomes. However, the clinical relevance of measuring and treating high thyroid-stimulating hormone (TSH) levels in newly diagnosed heart failure patients with preserved ejection fraction requires further study. In this report, we review the current evidence regarding the prognostic significance of subclinical hypothyroidism in heart failure patients with preserved ejection fraction.

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Thyroid Status, Cardiac Function, and Mortality in Patients With Idiopathic Dilated Cardiomyopathy

Cited by 52 publications

References 38 publications

Free Triiodothyronine Level Correlates with Myocardial Injury and Prognosis in Idiopathic Dilated Cardiomyopathy: Evidence from Cardiac MRI and SPECT/PET Imaging

Free Triiodothyronine Level Correlates with Myocardial Injury and Prognosis in Idiopathic Dilated Cardiomyopathy: Evidence from Cardiac MRI and SPECT/PET Imaging

Sub-Clinical Hypothyroidism and Its Association With Increased Cardiovascular Mortality: Call For Action!

Subclinical Hypothyroidism and Its Association with Increased Cardiovascular Mortality

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