Thyroid status and TNF-alpha in post-reproductive women with COVID-19 and 12 months after the disease

Semenova, N. V.; Kolesnikov, S. I.; Vyrupaeva, E. V.; Sholokhov, L. F.; Rychkova, L. V.; Petrova, А. G.; Akhmedzyanova, M. R.; Darenskaya, M. A.; Kolesnikova, L. I.

doi:10.29413/abs.2023-8.2.4

Cited by 3 publications

(1 citation statement)

References 35 publications

(4 reference statements)

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“…During menopause, women begin to experience agerelated neuroendocrine changes, accompanied by estrogen deficiency, which is considered as a condition for higher vulnerability to moderate and severe COVID-19 and subsequent complications [1]. It has been shown that menopausal women even 1 year after COVID-19, experience physical and emotional health problems, which may be due to endothelial dysfunction [2,3]. One of the mechanisms for the development of endothelial dysfunction is oxidative stress that develops during SARS-CoV-2 virus infection [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Menopausal women with moderate and asymptomatic COVID-19: antioxidant defense system biomarkers

Semenova,

Vyrupaeva,

Kolesnikov

et al. 2024

Acta biomedica scientifica

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The aim. The research was conducted to assess the total antioxidant and glutathione status, superoxide dismutase activity in menopausal women with moderate and asymptomatic COVID-19.Materials and methods. Ninety two women 45 to 69 years old were divided into groups: women without COVID-19, not vaccinated, with no antibodies to SARS-CoV-2 (IgG) – control; women with moderate COVID-19 – main group; women with anti-SARS-CoV-2 IgG in blood but who deny any symptoms of COVID-19 in the last 12 months – asymptomatic COVID-19.Results. A lower glutathione peroxidase (GPx), superoxide dismutase (SOD) activities and a higher glutathione reductase (GR) activity, glutathione S-transferase pi (GSTpi) concentrations were detected in the patients with moderate COVID-19 as compared to control. There were statistically lower oxidized glutathione (GSSG) levels, total antioxidant status (TAS) and higher reduced glutathione (GSH) levels, as well as GSH/GSSG ratio in the group with asymptomatic COVID-19 as compared to control. Significantly a lower GPx, SOD activities and a higher TAS, GR activity, GSTpi concentrations were detected in the patients with symptomatic COVID-19 as compared to group without clinical symptoms. ROC analysis shows the diagnostic significance of TAS (AUC = 0.714; p = 0.048), GSH (AUC = 0.714; p = 0.030), GSSG (AUC = 0.712; p = 0.031), GSH/GSSG (AUC = 0.837; p < 0.001) for group with asymptomatic COVID-19 compared with controls; TAS (AUC = 0.709; p = 0.020), SOD (AUC = 0.760; p < 0.001), GSH/GSSG (AUC = 0.658; p = 0.039), GPx (AUC = 0.774; p < 0.001), GSTpi (AUC = 0.864; p < 0.001) and GR (AUC = 0.871; p < 0.001) for group with moderate COVID-19 compared asympotmatic COVID-19.Conclusions. Antioxidant defense system activity in menopausal women depends on the COVID-19 course.

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Section: Introductionmentioning

confidence: 99%

Menopausal women with moderate and asymptomatic COVID-19: antioxidant defense system biomarkers

Semenova,

Vyrupaeva,

Kolesnikov

et al. 2024

Acta biomedica scientifica

Self Cite

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Endothelin Level in Menopausal Women with Comorbidity of the Acute Phase Middle Severity COVID-19 with Arterial Hypertension and Type 2 Diabetes Mellitus

Semenova,

Vyrupaeva,

Kolesnikov

et al. 2024

Bull Exp Biol Med

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Assessment of consequences of COVID-19 in adolescents by the method of questionnaire

Cherevikova,

Tkachuk,

Polyakov

et al. 2024

Acta biomedica scientifica

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Background. In Russia, of all detected cases of COVID-19, 18 % were in the pediatric population. According to a number of studies, adolescents develop long-term clinical and psychological consequences after an illness. Therefore, at present, the most relevant is a thorough study of the structure and severity of consequences of COVID-19 in adolescents.The aim of the research was to assess the severity of consequences of COVID-19 in adolescents depending on the time period after diseases.Methods. The sample included 96 people aged 11–16 years: 48 adolescents who have undergone COVID-19 (main group); 48 adolescents who did not have COVID-19 (control group). The main group was divided into six subgroups, depending on the period after COVID-19. The following research methods were used: clinical history using a standardized interview method; “Correction test” method by B. Bourdon; Beck’s Depression Inventory (BDI-1A); Adolescent’s Form of Manifest Anxiety Scale by A.M. Prikhozhan.Results. Clinical symptoms of COVID-19 during the acute phase of the disease were considered in adolescents. It has been established that the most common symptoms include fever, runny nose, cough, sore throat, severe fatigue, impaired sense of smell, impaired taste, headache (most often localized in the frontal region). Clinical and psychological symptoms characteristic of post-COVID syndrome were considered as consequences of COVID-19 in adolescents. The majority of the examined adolescents showed the following clinical symptoms of COVID-19 after discharge: asthenia, disturbances of smell and taste; lasting from 2 to 64 weeks. As psychological symptoms, adolescents were characterized by reduced attention span, reduced speed of information processing and concentration, as well as the presence of symptoms of severe depression and high anxiety. During the second month after COVID-19, the most unfavorable emotional state was revealed in adolescents.Conclusions. The data obtained made it possible to determine that post-COVID syndrome in adolescents is characterized by the presence of an asthenic condition, impaired attention, high anxiety, severe depressive symptoms.

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Thyroid status and TNF-alpha in post-reproductive women with COVID-19 and 12 months after the disease

Cited by 3 publications

References 35 publications

Menopausal women with moderate and asymptomatic COVID-19: antioxidant defense system biomarkers

Menopausal women with moderate and asymptomatic COVID-19: antioxidant defense system biomarkers

Endothelin Level in Menopausal Women with Comorbidity of the Acute Phase Middle Severity COVID-19 with Arterial Hypertension and Type 2 Diabetes Mellitus

Assessment of consequences of COVID-19 in adolescents by the method of questionnaire

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