Thyroid Scanning with 131Cs

Murray, I. P. C.; Stewart, Rosemary; Indyk, J. S.

doi:10.1136/bmj.4.5736.653

Cited by 30 publications

(3 citation statements)

References 3 publications

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“…Как и в ситуации с радиогаллием, возможности сцинтиграфии с радиоцезием в оценке риска злокачественности трактовались неоднозначно. Ряд авторов указывали на высокие значения чувствительности (83%), специфичности (87%), предсказуемости положительного (84%) и отрицательного (93%) результатов [24]. Выдвинуто предположение, что характер аккумуляции РФП в узле ЩЖ зависит от его васкуляризации и клеточной пролиферации, а также опосредован большим содержанием в опухолях щелочных металлов, в частности родственного цезию химического элемента калия.…”

Section: метаболический скрининг узлов щитовидной железыunclassified

Scintigraphy in Thyroid Nodular Pathology

Mironov

Сергиенко

2022

Vestn. rentgenol. radiol.

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Thyroid scintigraphy is a method that formed more than 60 years ago and retains its importance for the diagnosis and assessment of the risk of nodular malignancy. The review examines the use of the scintigraphic method in functional and metabolic assessment of nodular goiter. Prerequisites for functional thyroid nodes screening with short-lived 99mTc-pertechnetate are outlined. Information is provided on the principles of its preparation and pharmacokinetics, as well as variants of the thyroid nodes functional activity, their possible malignant potential and indications for metabolic screening. The characteristic of metabolic activity allows to assess the risk of functionally “cold” thyroid nodes malignancy. The main stages of the use of nonspecific tumorotropic radiopharmaceuticals, the mechanism of their accumulation and metabolism in the thyroid tumors, the possibilities of the differential diagnosis of various types of nodular formations are presented. Modern views on the diagnostic capabilities of two-phase scintigraphy with 99mTс-methylisobutylisonitrile are reflected taking into account the relationship of radiopharmaceuticals accumulation with factors of proliferative activity and ultrastructural cell types, a variant of oncocytic pathology and multidrug-resistant protein expression.

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Section: метаболический скрининг узлов щитовидной железыunclassified

Scintigraphy in Thyroid Nodular Pathology

Mironov

Сергиенко

2022

Vestn. rentgenol. radiol.

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“…Die computerisierte Erforschung von 120 von 293 Patienten zeigte: (a) eine Übereinstimmung zwischen klinisch-histologischer und radioisotopischer Diagnose in 76 der 79 kolloid-zystischen Neubildungen, in allen 16 Neoplasien und in 23 der 25 gutartigen Knoten; (b) eine signifikant statistische Unterscheidung der Dichte-Indexe zwischen soliden und zystischen Knoten, aber nicht zwischen gutartigen und bösartigen; (c) ein unterschiedliches kinetisches Verhalten des 201 T1 in soliden Neubildungen verschiedenartiger Natur mit einem statistisch ausreichenden Unterschied im Verschwinde-Index aus dem Knoten. 201 Tl-chloride was suggested and has been tested in the differential diagnosis of cold thyroid nodules (7) on the same application premises of another potassium analogue, 131 Cs (6,12), previously also employed in myocardial scanning for which thallium is now used more widely (4).…”

Section: Computerisierte Untersuchungen Des Kalten Schilddrüsenknotenunclassified

Computerized Study with 201T1 of the Cold Thyroid Node

Palermo¹,

Saitta²,

Coghetto³

et al. 1982

Nuklearmedizin

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Because of its physical and potassium-metabolic characteristics 201T1 is more suitable than 131Cs for radioisotopic studies of the cold thyroid nodule, with the further diagnostic possibility of quantitatively assessing intranodular behaviour for a specific differentiation among different kinds of neoformations. Using a gamma-camera on line with a computer data processing device, sequential scintiscans were recorded for the first 20-30 min after i. v. administration of 15-20 MCi\lkg of radiothallium; delayed sequences were taken at 40-60 min if intranodular uptake appeared. A quantitative appraisal was made of the differential 201Tl uptake-ratio between nodule and healthy thyroid tissue (density-index) and the multiparameter analysis of thyroid time/activity curves generated on the relative regions of interest (ROIs). This computerized study, in 120 out of 293 patients submitted to this radiothallium test, has shown a) diagnostic agreement between clinical-histological and radioisotopic findings in 76 out of 79 colloid-cystic or degenerative neoformations, in all 16 malignant and in 23 out of 25 hyperplastic benign nodules; b) significant statistical difference of the density-index in solid versus cystic but not between benign and malignant nodules; c) different 201T1 kinetics behaviour in different kinds of solid thyroid lesions with a satisfactory statistical difference of the radiothallium nodular dissapearance-index.

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“…Other radionuclides used: Several other radionuclides, such as cesium 131, 25 selonium 75-methionine, 26 gallium 67-citrate, 27 and technetium-bleomycin, 28 have been used for thyroid scanning but their false negative rate is high enough to rule out their use.…”

Section: Other Uses For the 99m Tc Scanmentioning

confidence: 99%

Is the Technetium 99M Scan Useful in Screening for Nontoxic Solitary Thyroid Nodules?

Al-Tameem

1990

Ann Saudi Med

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The proposed benefits of the technetium ( 99m Tc) scan in the screening of patients with clinically solitary thyroid nodules were assessed. One hundred seventy-eight patients with such lesions underwent Tc scanning followed by surgical resection. The solitary nature of the lesion was confirmed by Tc scanning in 153 (86%) patients. In the remaining 25 (14%), the scan showed patchy uptake by the thyroid gland, suggesting subclinical multinodularity. Of these 25 patients with conflicting clinical and scan findings, the lesion was confirmed to be solitary by operative and pathological findings in ten (40%) patients, of whom two patients had thyroid malignancies that might have been misdiagnosed as multinodular goiter. In the other 15 (60%) patients, the scan was accurate in detecting subclinical multinodularity, but again, two patients in this group had thyroid malignancies that might have been misdiagnosed as multinodular goiter. These findings indicate that the 99m

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Thyroid Scanning with 131Cs

Cited by 30 publications

References 3 publications

Scintigraphy in Thyroid Nodular Pathology

Scintigraphy in Thyroid Nodular Pathology

Computerized Study with 201T1 of the Cold Thyroid Node

Is the Technetium 99M Scan Useful in Screening for Nontoxic Solitary Thyroid Nodules?

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