Thyroid-related hormones as potential markers of hypoxia/ischemia

Tani, Naoto; Ishikawa, Mayumi; Watanabe, Miho; Ikeda, Tomoya; Ishikawa, Takaki

doi:10.1007/s13577-020-00341-x

Cited by 10 publications

(14 citation statements)

References 35 publications

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“…Moreover, a few clinical studies, including randomized controlled trials [ 47 , 48 ], reported the therapeutic effects of the improvement of blood flow in the inner ear using betahistine in BPPV patients [ 49 ]. Several previous studies have suggested an association between abnormal levels of thyroid-related hormones and cardiovascular circulations [ 50 , 51 ]. Some prior studies have proposed increased thyroid-related hormones, including T3 and T4, in conditions of acute systemic ischemia [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several previous studies have suggested an association between abnormal levels of thyroid-related hormones and cardiovascular circulations [ 50 , 51 ]. Some prior studies have proposed increased thyroid-related hormones, including T3 and T4, in conditions of acute systemic ischemia [ 50 ]. On the other hand, reduced levels of thyroid-related hormones were also related to cardiovascular compromise [ 9 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

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Analyses of the Relation between BPPV and Thyroid Diseases: A Nested Case-Control Study

et al. 2021

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Background: This study investigated relationship between multiple thyroid disorders and benign paroxysmal positional vertigo (BPPV), adjusting for levothyroxine medication. Methods: The Korean National Health Insurance Service-Health Screening Cohort data from 2002 to 2015 were used. A total of 19,071 patients with BPPV were matched with 76,284 participants of a control group in a ratio of 1:4 for age, sex, income, and region of residence. The previous histories of thyroid disorders such as goiter, hypothyroidism, thyroiditis, hyperthyroidism, and autoimmune thyroiditis were investigated in both the BPPV and control groups. The odds ratios (ORs) for BPPV in thyroid diseases were calculated using conditional logistic regression analyses. Results: The histories of goiter (5.5% vs. 4.1%), hypothyroidism (4.7% vs. 3.7%), thyroiditis (2.1% vs. 1.6%), and hyperthyroidism (3.1% vs. 2.5%) were higher in the BPPV group than in the control group (all p < 0.001). Goiter, hypothyroidism, thyroiditis, and hyperthyroidism were associated with BPPV (adjusted OR = 1.28 (95% CI =1.17–1.39) for goiter, 1.23 (95% CI =1.10–1.37) for hypothyroidism, 1.13 (95% CI = 1.02–1.26) for hyperthyroidism, each p < 0.05). Conclusions: BPPV was associated with thyroid disorders such as goiter, hypothyroidism, thyroiditis, and hyperthyroidism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analyses of the Relation between BPPV and Thyroid Diseases: A Nested Case-Control Study

et al. 2021

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“…A brief review of the recent literature revealed just a small number of articles addressing asphyxia through experimental protocols. Several approaches have been proposed 1 – 7 , mainly focused on the effects of asphyxial mechanisms, while little is known about the real-time biological modifications that occur during hypoxic-ischaemic insult. It was recently demonstrated 8 that only exceptionally long asphyxial periods can produce lungs histological modifications, whilst alterations can be observed at cellular and, especially, molecular level.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model

Locci

Chighine

Noto

et al. 2021

Sci Rep

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The diagnosis of mechanical asphyxia remains one of the most difficult issues in forensic pathology. Asphyxia ultimately results in cardiac arrest (CA) and, as there are no specific markers, the differential diagnosis of primitive CA and CA secondary to asphyxiation relies on circumstantial details and on the pathologist experience, lacking objective evidence. Histological examination is currently considered the gold standard for CA post-mortem diagnosis. Here we present the comparative results of histopathology versus those previously obtained by 1H nuclear magnetic resonance (NMR) metabolomics in a swine model, originally designed for clinical purposes, exposed to two different CA causes, namely ventricular fibrillation and asphyxia. While heart and brain microscopical analysis could identify the damage induced by CA without providing any additional information on the CA cause, metabolomics allowed the identification of clearly different profiles between the two groups and showed major differences between asphyxiated animals with good and poor outcomes. Minute-by-minute plasma sampling allowed to associate these modifications to the pre-arrest asphyxial phase showing a clear correlation to the cellular effect of mechanical asphyxia reproduced in the experiment. The results suggest that metabolomics provides additional evidence beyond that obtained by histology and immunohistochemistry in the differential diagnosis of CA.

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“…In an earlier report we found blood and cerebrospinal fluid (CSF) to have increased levels of triiodothyronine (T3) and thyroxine (T4). Thyroid gland secretions were high during acute hypoxic/ischemic conditions, regardless of any mechanical stimuli such as cervical compression [8]. We also found an increase in the pituitary gland blood-to-CSF transport of prolactin (PRL).…”

Section: Introductionmentioning

confidence: 72%

“…As a result, we have conducted several studies designed to investigate endocrine system abnormalities that occur due to systemic hypoxia [8][9][10]. In an earlier report we found blood and cerebrospinal fluid (CSF) to have increased levels of triiodothyronine (T3) and thyroxine (T4).…”

Section: Introductionmentioning

confidence: 99%

Morphological and biochemical changes in the pancreas associated with acute systemic hypoxia

et al. 2021

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This study aimed to investigate the changes associated with acute systemic hypoxia in the endocrine system, particularly in pancreatic tissues. The investigation was based on macroscopic, pathohistological, biochemical, and molecular biological findings in cell lines and human cadavers. The results showed that cases of death due to asphyxia more frequently showed severe subcapsular/interstitial hemorrhage versus the other causes of death. Histological examination showed that asphyxia cases were associated with severe morphological changes. Although measured insulin levels in the asphyxia were higher compared to other causes of death, no differences were noted for the glucagon and amylase levels with regard to the cause of death. Increased blood insulin levels were not associated with macro- and micromorphological changes, and did not show any association with glucose or cortisol levels. The experiment conducted under hypoxic conditions in cultured cells demonstrated that insulin mRNA expression and insulin protein levels peaked at 10 min after hypoxia exposure. However, there were no changes in either the amylase mRNA or protein levels. Corticosterone level peaked at 120 min after exposure to hypoxic conditions. Overall, acute systemic hypoxic conditions can directly affect the mechanisms involved in pancreatic insulin secretion.

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Thyroid-related hormones as potential markers of hypoxia/ischemia

Cited by 10 publications

References 35 publications

Analyses of the Relation between BPPV and Thyroid Diseases: A Nested Case-Control Study

Analyses of the Relation between BPPV and Thyroid Diseases: A Nested Case-Control Study

Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model

Morphological and biochemical changes in the pancreas associated with acute systemic hypoxia

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