Thyroid Peroxidase Antibody (TPO) as a Predictor of Radiation Induced Thyroid Dysfunction Among Nurses and Technicians Working in Mansoura Specialized Medical Hospital: Cross Sectional Study

Abstract

Background:: Thyroid gland is a probable goal tissue for radiation-related injury. Occupational exposure to ionizing radiation leads to thyroid dysfunction and exposure to high dose may lead to thyroid carcinoma. Objective:: Evaluation of the role of Thyroid peroxidase antibody as a predictor for thyroid dysfunction among nurses and technicians in the radiology department in Mansoura Specialized Medical hospital (MSMH). Subjects and Methods:: Subjects were Nurses and technicians who are working in (MSMH) with persistent daily duty in the last 3 years and fulfilling the inclusion and exclusion criteria. All subjects included in the study were recruited in one month and divided into two groups; Group 1: 50 subjects who were working in radiology, coronary angiography and ERCP unit, Radiation -exposed group. Group 2: 33 subjects who were working in In-patient departments and in out- patient clinics and not exposed to any type of radiation. Non fasting blood sample was taken from all enrolled subjects for measurement of TSH and Anti-TPO. Results:: TPO was positively and significantly correlated to age, TSH, duration of radiology/ y (r=0.388, 0.364, 0.342respectively) p value <0.05. Roc curve was done to detect the sensitivity and specificity of TSH in relation to TPO that revealed the cutoff value of TSH > 1.69 with Sensitivity and Specificity. PPV, NPV and accuracy at cutoff >1.69 were 70.6%, 51.5%, 42.8%, 77.3% and 58%. Conclusion:: Working personnel with positive anti TPO and their TSH levels are more than 1.69 associated with symptoms of hypothyroidism, a trial of treatment is mandatory to relieve symptoms.

Assessment of thyroid gland hormones and ultrasonographic abnormalities in medical staff occupationally exposed to ionizing radiation

“…A recent study by Albehairy A et al [ 31 ] is constant with the present study, indicating that working personnel in the radiation field are positive for anti-TPO. In autoimmune thyroid disorders, thyroid autoantibodies such as a thyroid-stimulating antibody, anti-thyroglobulin antibody, and anti-thyroperoxidase antibody can be found.…”

Correlates of Positive Thyroid Peroxidase Antibodies Among Firefighters: A Cross-Sectional-Study

“…Some of the factors examined in this study include age, gender, race/ethnicity, family history of thyroid diseases, cigarette smoking, and ionizing radiation exposure. Age in our study was not a significant predictor of TPOAb; however, most (95%; 266 of 278) of our study participants are in a relatively restrictive age range (30-64 years) where TPOAb are the highest levels compared to the extreme of ages [ 23 , 27 , 29 ]. A preponderance of TPOAb and autoimmune diseases is found among females than among males [ 13 , 29 ], and risk is increased by occupational exposure such as radiation [ 29 ].…”

“…Reported occupational radiation exposure increased the odds of being TPOAb positive by 16% in our study population, but this finding was not significant. Several studies have shown an association between radiation exposure including medical radiation and increased risk of autoimmune thyroid disorder [ 13 , 23 , 44 ]. A dose-effect relation between the high dose of radiation exposure and autoimmune thyroid disease has been reported; however, firefighters are not typically exposed to high doses of radiation.…”

“…Occupational and sociodemographic factors may increase or decrease hazards and chemical occupational risk exposure among firefighters; the chronic long-term effects of these exposures are unclear [ 21 , 22 ]. While several studies have examined the prevalence and risk of autoimmune thyroid antibodies among occupational groups such as nurses, technicians, and other hospital workers [ 23 ], and in the general population [ 6 ], there is a paucity of information among firefighters. In this study, we examine the prevalence of TPOAb and associated sociodemographic and occupational correlates among a study population of firefighters.…”

The Effect of High-Quality Nursing Management on Thyroid Tumor Patients after Bipolar Coagulation

“…Bipolar coagulation has been widely employed in clinical treatment due to its clear surgical field and low intraoperative blood loss and has achieved significant clinical effects [ 16 – 18 ]. However, the propensity for various complications such as hematoma, incision infection, hypothyroidism, and hoarseness after thyroid surgery, combined with the negative emotions and pain, poses a great psychological pressure on the patients, which results in a somber prognosis [ 19 , 20 ]. It has been clinically discovered that proper nursing measures for thyroid patients after treatment can effectively alleviate the patients' negative emotions, improve the patient's quality of life and self-care ability, which is conducive to creating a harmonious nurse-patient relationship and promoting a quick recovery.…”