Thyroid papillary carcinoma arising in ectopic thyroid tissue within a branchial cleft cyst

Karras, Spyridon Ν.; Anagnostis, Panagiotis; Noussios, George; Pontikides, Nikolaos

doi:10.1136/bcr-2013-009312

Cited by 9 publications

(7 citation statements)

References 17 publications

(17 reference statements)

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“…SLN, as the first stop of tumor metastasis, is the node for drainage of primary cancers in regional lymphoid tissues. 6 The metastasis is helpful to determine tumor stage, prognosis and treatment regimen. 7 There have been many reports since SLN biopsy was first applied in thyroid cancer surgery in 1998.…”

Section: Discussionmentioning

confidence: 99%

Recognition of sentinel lymph nodes in patients with papillary thyroid cancer by nano-carbon and methylene blue

Liu¹,

Zhu²,

Qian³

et al. 2017

Pak J Med Sci

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Objective:To compare the accuracy and feasibility of methylene blue and nano-carbon in clinical tracing of sentinel lymph nodes (SLNs) in patients with papillary thyroid cancer (PTC).Methods:Ninety-six PTC patients were selected and randomly divided into a methylene blue group and a nano-carbon group (n=48). During surgery, tracer agent was injected around the tumor, and SLNs were resected and subjected to frozen pathological examination. The results were compared with those of routine pathological examination after surgery.Results:Latent lymph node metastasis (level VI and lateral neck) was detected in both groups, with neck distribution of SLNs. There was no significant difference in the detection rate or accuracy of SLNs between two groups (P>0.05). The incorrect resection rate of parathyroid gland and incidence of temporary hypoparathyroidism in the methylene blue group were significantly higher than those of the nano-carbon group (t=4.137, P<0.05).Conclusions:The state of PTC lymph nodes can be well evaluated by SLN biopsy using both methylene blue and nano-carbon as tracers, but using nano-carbon has a lower incidence rate of parathyroid injury, with great clinical prospects accordingly.

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Section: Discussionmentioning

confidence: 99%

Recognition of sentinel lymph nodes in patients with papillary thyroid cancer by nano-carbon and methylene blue

Liu¹,

Zhu²,

Qian³

et al. 2017

Pak J Med Sci

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“…Cervical cystic metastasis remains a challenging issue for preoperative diagnosis, with an incidence ranging from 33% to 62% [ 10 ]. Cervical cystic diseases may be associated with BCC, BC, cervical cystic CUP, cystic necrotic schwannoma, lymph node with necrotic granulomatous inflammation, lymphangioma, venous malformation, lymphoma with cystic degeneration, metastatic papillary thyroid carcinoma [ 10 , 25 ], or malignant ectopic thyroid glands [ 26 , 27 ]. The diagnosis of BC remains controversial and excluding other potential similar presentations, such as cervical cystic CUP, is paramount.…”

Section: Discussionmentioning

confidence: 99%

Cervical metastasis of gingival carcinoma misdiagnosed as branchiogenic carcinoma, a rare entity - report of a case and review of literature

Sun¹,

Chen²,

Sun³

et al. 2017

BMC Oral Health

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BackgroundA cervical cystic mass is associated with a number of pathologies that present with similar symptoms. These conditions are difficult to differentiate using fine-needle aspiration (FNA), ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI). Another dilemma in the differential diagnosis of cervical cystic masses is due to the controversies associated with the existence of branchiogenic carcinoma (BC). BC is an extremely rare disease that must be differentiated from other conditions presenting with cervical cystic masses, especially cystic metastasis from occult primary lesions.Case presentationWe present a case report of a right cervical cystic metastasis from a significantly small squamous cell carcinoma primary gingival lesion misdiagnosed as BC by histopathology. A 62-year-old female presented with a painless progressively enlarging cervical mass at the anterior edge of the sternocleidomastoid muscle in the right submandibular region. Preoperative MRI and US revealed a well-defined cystic round mass. Postoperative histological examination indicated BC. Positron emission tomography/computed tomography (PET/CT) revealed high 18F–FDG (18F 2-fluoro-2-deoxy-D-glucose) uptake in surgical regions with a SUV (standard uptake value) max 4.0 and ipsilateral nasopharynx with a SUVmax 4.4, without any distant metastasis. Pathologic results revealed nasopharyngeal lymphadenosis. Considering the low incidence of BC and the limitation of diagnosis in one institution, the patient was referred to another hospital. Physical examination detected a significantly small neoplasm (~3 mm diameter) in the right lower gingiva. Histopathological examination of the neoplasm revealed a well-differentiated squamous cell carcinoma. Surgery, including a partial mandibulectomy and modified neck dissection (neck level I–V and submental lymph nodes) were undertaken. Postoperative histopathological results revealed a well-differentiated squamous cell carcinoma of right lower gingiva and two metastatic lymph nodes in the 18 lymph nodes of level II. A month later, recurrence occurred in the right cervical level II. The patient was placed on postoperative concurrent chemo-radiotherapy and supportive care. The patient suffered from cachexia and survived for only six months after surgery.ConclusionsIn cases of cervical cystic masses that appear after the age of 40, clinicians should bear in mind that occult primary lesions should be excluded and examination of the gingiva should be undertaken. PET/CT has a limited role in identifying small occult primary lesions and a comprehensive physical examination must be carefully performed.

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“…3,4 Only a few cases of this disease have been reported previously (table ). [5][6][7][8][9][10][11][12][13][14] Herein, we report a new case of a lateral neck cyst that represented a primary papillary carcinoma arising from ectopic thyroid tissue within a branchial cleft cyst.…”

Section: Introductionmentioning

confidence: 99%

Wrong Egg in the Usual Nest: Thyroid Papillary Carcinoma within a Branchial Cleft Cyst

et al. 2013

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Branchial cleft cysts are the most common lesions to arise laterally in the neck. Ectopic thyroid tissue within a branchial cleft cyst is rare, and a papillary carcinoma arising from this tissue is extremely rare. We present a case of a lateral neck cyst representing a primary papillary carcinoma that arose in ectopic thyroid tissue within a branchial cleft cyst in a 41-year-old woman. After the mass was surgically excised, thyroid ultrasonography, thyroid scintigraphy, and whole-body F18-fluorodeoxyglucose-positron emission tomography/computed tomography detected no abnormality. The negative findings notwithstanding, surgery on the thyroid gland was planned, but the patient refused it. Therefore, she was followed up with ultrasonography and scintigraphy for 5 years, during which time she exhibited no evidence of recurrence. Total thyroidectomy is still the primary option in such cases, but when it cannot be performed for any reason, vigilant follow-up is essential.

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Thyroid papillary carcinoma arising in ectopic thyroid tissue within a branchial cleft cyst

Cited by 9 publications

References 17 publications

Recognition of sentinel lymph nodes in patients with papillary thyroid cancer by nano-carbon and methylene blue

Recognition of sentinel lymph nodes in patients with papillary thyroid cancer by nano-carbon and methylene blue

Cervical metastasis of gingival carcinoma misdiagnosed as branchiogenic carcinoma, a rare entity - report of a case and review of literature

Wrong Egg in the Usual Nest: Thyroid Papillary Carcinoma within a Branchial Cleft Cyst

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