Thyroid neoplasia following irradiation for medulloblastoma. Report of two cases

Roggli, Victor L.; Estrada, Rolando; Fechner, Robert E.

doi:10.1002/1097-0142(197906)43:6<2232::aid-cncr2820430612>3.0.co;2-u

Cited by 24 publications

(1 citation statement)

References 15 publications

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“…Thyroid cancers and gliomas have been seen following completion of therapy [90,91], and it is likely that prolongations of survival resulting from combined modality therapy will facilitate identification of additional second malignancies.…”

Section: Price Of Interventionmentioning

confidence: 99%

Medulloblastoma: tumor biological and clinical perspectives

et al. 1991

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Medulloblastoma is the most common central nervous system malignancy of childhood, with approximately 350 new cases seen in the United States each year. Although the low incidence of this tumor, compared with adult neoplasms such as breast or colon carcinoma, has limited laboratory and clinical research, recent studies have greatly enhanced our understanding of the biology, phenotype, genotype, and therapy of medulloblastoma. Further efforts to integrate laboratory and clinical studies of this tumor may allow design of novel therapeutic approaches resulting in enhanced disease-free survival.

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Section: Price Of Interventionmentioning

confidence: 99%

Medulloblastoma: tumor biological and clinical perspectives

et al. 1991

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Systemic metastases from medulloblastoma: Report of two cases and review of the literature

Kleinman

Hochberg

Richardson

1981

Cancer

104

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The clinical and pathologic data from two cases of medulloblastoma with systemic metastases, and 101 previously reported cases were evaluated to define better the clinical presentation and natural history. Patients ranged in age from six months to 48 years, with a mean of 13 years; two thirds of the patients were male. Ventricular shunts had been inserted in 20% of the patients. Systemic metastases occurred on an average of two years after the diagnosis of the primary tumor in patients without shunts, but only 1.3 years in patients with shunts. Fifty-nine percent of the patients were known to have experienced recurrence or spread of medulloblastoma within the central nervous system by the time systemic metastases appeared. Ninety percent showed radiologic evidence of bone metastases, of which 60% were osteoblastic. Bones most frequently involved were pelvis, femur and vertebrae; pain was the most common initial symptom. At autopsy, lymph node metastases were found in 65% and liver metastases were found in 28% of all cases in addition to bone metastases in 82%. Lung metastases occurred in 9% of the patients without shunts, compared with 30% of patients with shunts. The average survival was seven months after the appearance of systemic metastases for patients both with and without shunts. Approximately 5% of patients with medulloblastoma may be expected to develop systemic metastases. This development is associated with increased morbidity and a shortened life expectancy.

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Assessment of the long-term effects of primary radiation. Therapy for brain tumors in children

Danoff

Cowchock

Marquette

et al. 1982

Cancer

281

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One-hundred-twelve children with primary brain tumors received definitive radiotherapy between the years 1958--1979. Sixty-nine patients were alive at intervals of 1--21 years. Thirty-eight patients underwent neurologic and endocrine evaluation, psychologic and intelligence testing, and assessement for second malignancy post-treatment. A second intracranial malignancy developed in one child, for an incidence of 1.6%. Performance status was good to excellent in 89% of the patients studied. Seventeen percent of the group were mentally retarded. Behavioral disorders were identified in 39% of the patients, 59% of the mothers, and 43% of the fathers. Of the 23 patients with nonparasellar tumors, six were found to have growth hormone deficiency, including two patients with panhypopituitarism. Disability was related to age under 3 years at the time of treatment and tumor extension to the hypothalamus.

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Thyroid neoplasia following irradiation for medulloblastoma. Report of two cases

Cited by 24 publications

References 15 publications

Medulloblastoma: tumor biological and clinical perspectives

Medulloblastoma: tumor biological and clinical perspectives

Systemic metastases from medulloblastoma: Report of two cases and review of the literature

Assessment of the long-term effects of primary radiation. Therapy for brain tumors in children

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