Thyroid Microcalcifications in the Absence of Identifiable Nodules and Their Association With Thyroid Cancer

Whittle, Carolina; Garcia, M Granados; Horvath, Eleonora; Slater, Jeannie; Carrasco, Carmen Eloy-García

doi:10.1002/jum.14667

Cited by 9 publications

(8 citation statements)

References 8 publications

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“…Nodules with predominantly cystic component, simple cyst, spongiform, hyper-/isoechogenic, oval, and with circumscribed margins were associated with the histological diagnosis of benign lesions. This is in accordance with the results of previous studies [17-20].…”

Section: Discussionsupporting

confidence: 94%

Accuracy of the European Thyroid Imaging Reporting and Data System (EU-TIRADS) in the valuation of thyroid nodule malignancy in reference to the post-surgery histological results

Skowrońska

Milczarek-Banach

Wiechno

et al. 2018

pjr

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PurposeTo assess the clinical usefulness of the European Thyroid Imaging and Reporting Data System (EU-TIRADS) in the valuation of thyroid nodules malignancy in reference to post-surgery histological results.Material and methodsPre-operative ultrasound was performed in consecutive patients admitted for thyroid surgery between June 2017 and January 2018. Thyroid nodules were classified according to EU-TIRADS to five groups: 1-5. At least one fine-needle aspiration biopsy (FNAB)/patient (dominant or suspected nodule) was performed in an outpatient clinic. The final diagnosis was based on the histological result. The percentage of cancers in each EU-TIRADS group was evaluated. Finally, sensitivity, specificity, accuracy, as well as positive and negative predictive values for malignancy were assessed.ResultsFifty-two patients with a total of 140 thyroid nodules (median: 3 nodules/thyroid [minimum-maximum: 1-6]) were enrolled in the study. Thyroid cancer was diagnosed in 0% (0/6) in EU-TIRADS 2; 0% (0/92) in EU-TIRADS 3; 5.9% (2/34) in EU-TIRADS 4, and 75% (6/8) in EU-TIRADS 5. In nodules assessed as EU-TIRADS ≥ 4 sensitivity, specificity, positive and negative predictive values for malignancy were, respectively: 75% (CI 95%: 40.7-93.5), 94.1% (CI 95%: 86.0-98.5), 75% (CI 95%: 40.7-93.5), and 94.1% (CI 95%: 86.0-98.5).ConclusionsEU-TIRADS is a valuable and simple tool for assessment of the risk of malignancy of thyroid nodules and demonstrates a high ultrasound correlation with histological post-surgery results. FNAB should be performed in all nodules assessed as EU-TIRADS ≥ 4, due to higher risk of malignancy.

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Section: Discussionsupporting

confidence: 94%

Accuracy of the European Thyroid Imaging Reporting and Data System (EU-TIRADS) in the valuation of thyroid nodule malignancy in reference to the post-surgery histological results

Skowrońska

Milczarek-Banach

Wiechno

et al. 2018

pjr

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“…In our study, the presence of microcalcification and hypoechogenicity in the US images and the presence of suspected and malignant cytologic results from the FNAB findings were found to be significant in favor of malignancy, in accordance with the results reported in previous studies ( P < .001 for all 3). Microcalcification is one of the most common characteristics of malignant nodules . This study's results confirmed that finding.…”

Section: Discussionsupporting

confidence: 88%

“…Microcalcification is one of the most common characteristics of malignant nodules. 30 This study's results confirmed that finding.…”

Section: Discussionsupporting

confidence: 86%

Which Is the Best Reference Tissue for Strain Elastography in Predicting Malignancy in Thyroid Nodules, the Sternocleidomastoid Muscle or the Thyroid Parenchyma?

Görgülü

2019

J of Ultrasound Medicine

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Objectives This study aimed to compare 2 types of strain ratios (SRs) in thyroid nodules. Two reference points were used: the sternocleidomastoid (SCM) muscle and the thyroid parenchyma. Methods A total of 101 nodules in 83 patients were prospectively enrolled in the study. For the semiquantitative analysis, 2 types of SRs were used: SR1, the ratio of the SCM muscle strain to the thyroid nodule strain; and SR2, the ratio of the surrounding normal thyroid tissue strain to the thyroid nodule strain. For each nodule, the SR1 and SR2 elastographic values were calculated, and their averages were compared. Results Eighty‐one (80.2%) of 101 thyroid nodules were benign, and 20 (19.8%) were malignant. In both benign and malignant histopathologic types, the SR1 averages were significantly higher than the SR2 averages (P = .001; P < .001, respectively). Both the SR1 and SR2 values were found to be significantly successful in differentiating benign from malignant histopathologic types (P < .001 for both). The areas under the curve were then compared for the methods, and the difference was found to be statistically significant (P = .046). The diagnostic accuracy of the SR1 was superior to that of the SR2. Conclusions The SR1 and SR2 are effective adjunctive diagnostic tools for identifying malignant thyroid nodules. Using the SCM muscle as a reference point instead of thyroid tissue may be a more valuable way to measure SRs.

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“…Under these circumstances a close evaluation of bone loss status is necessary in order to decide anti-osteoporotic therapy (19,20). Case 3 had microcalcifications at thyroid ultrasound microcalcification which are very suggestive for papillary thyroid cancer even in the absence of a large nodule; the risk is higher in younger patients and if the autoimmune thyroid background is positive (21). However, in this case there was no confirmation of thyroid malignancy after pathological report was performed.…”

Section: Discussionmentioning

confidence: 84%

Mammary cancer: Sneak peek to thyroid nodules

Păun¹,

Cârșote²,

Valea³

et al. 2019

Ro Med J.

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Thyroid Microcalcifications in the Absence of Identifiable Nodules and Their Association With Thyroid Cancer

Cited by 9 publications

References 8 publications

Accuracy of the European Thyroid Imaging Reporting and Data System (EU-TIRADS) in the valuation of thyroid nodule malignancy in reference to the post-surgery histological results

Accuracy of the European Thyroid Imaging Reporting and Data System (EU-TIRADS) in the valuation of thyroid nodule malignancy in reference to the post-surgery histological results

Which Is the Best Reference Tissue for Strain Elastography in Predicting Malignancy in Thyroid Nodules, the Sternocleidomastoid Muscle or the Thyroid Parenchyma?

Mammary cancer: Sneak peek to thyroid nodules

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