Thyroid malignancy risk in different clinical thyroid diseases

Dirikoç, Ahmet; Fakı, Sevgül; Başer, Hüsniye; Özdemır, Didem; Aydın, Cevdet; Ersoy, Reyhan; Kılıç, Mehmet; Kılıçarslan, Aydan; Çakır, Bekir

doi:10.3906/sag-1611-67

Cited by 12 publications

(11 citation statements)

References 35 publications

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“…33 Although rates as low as 2.3% was reported in some previous studies, 6 recent studies revealed much higher rates reaching to 13.7%. 33 Although rates as low as 2.3% was reported in some previous studies, 6 recent studies revealed much higher rates reaching to 13.7%.…”

Section: Discussionmentioning

confidence: 83%

“…A wide range of prevalence of malignancy in hyperthyroid patients was reported in the literature. 33 Although rates as low as 2.3% was reported in some previous studies, 6 recent studies revealed much higher rates reaching to 13.7%. 34 The prevalence of malignancy in hyperthyroid patients is beyond the scope of our study, however the possibility of an existing tumor before RAI can not be excluded completely.…”

Section: Discussionmentioning

confidence: 85%

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Evaluation of ultrasonographical and cytological features of thyroid nodules in patients treated with radioactive iodine for hyperthyroidism

Bilginer¹,

Özdemır

Seyrek

et al. 2019

Diagnostic Cytopathology

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Background: In this study, we aimed to evaluate ultrasonographical and cytological features of thyroid nodules in patients who were treated with radioactive iodine (RAI) for hyperthyroidism years ago. Methods:Patients who had a history of RAI treatment for hyperthyroidism and had thyroid nodules that were evaluated with fine-needle aspiration biopsy (FNAB) were included in the study.Results: There were 27 patients (22 female and 5 male) with a mean age of 59.3 ± 13.5.The indication for RAI treatment was Graves in 5 (18.6%), toxic nodular or multinodular goiter in 16 (69.2%), and unknown in 6 (22.2%) patients. A total of 48 thyroid nodules were evaluated with FNAB and cytological diagnosis were benign in 24 (50.0%), nondiagnostic in 15 (31.2%), atypia of undetermined significance in 5 (10.4%), suspicous for malignancy in 2 (4.2%), and malignant in 2 (4.2%) nodules. Thyroidectomy was performed in 10 patients, 5 were benign (50.0%), and 5 (50.0%) were malignant histopathologically. Ultrasonography features of 31 cytologically/histopathologically benign and five cytologically/histopathologically malignant nodules were compared. Prevalence of isoechoic nodules was higher in benign nodules (P = .025). Macrocalcification was observed in 4 (80.0%) of malignant and 10 (32.3%) of benign nodules (P = .042). Conclusion:In patients with a history of RAI treatment for hyperthyroidism, thyroid nodules with suspicious ultrasonography features, particulary hypoechoic appearence and macrocalcification, should be evaluated with FNAB irrespective of the time elapsed after RAI treatment. K E Y W O R D Scytology, fine-needle aspiration biopsy, histopathology, hyperthyroidism, radioactive iodine

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 85%

Evaluation of ultrasonographical and cytological features of thyroid nodules in patients treated with radioactive iodine for hyperthyroidism

Bilginer¹,

Özdemır

Seyrek

et al. 2019

Diagnostic Cytopathology

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“…However, in a previous study from our center, the malignancy rate in TNG and TMNG patients was 24.7%. 19 The number of studies evaluating TRAb in patients with TMNG is limited. Pederson et al found positive TRAb in 97 of 106 patients with Graves, 15 of 94 with TMNG and 1 of 100 healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Thyrotrophin receptor antibody is not associated with thyroid cancer in patients with toxic nodular and multinodular goiter

Aydın¹,

Başer²,

Çuhacı³

et al. 2020

Ankara Med J

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Öz Amaç: Graves hastalarında tiroid kanser sıklığı ve agresifliği ile yüksek tirotropin reseptör antikor (TRAb) düzeyleri arasında ilişki bildirilmiştir. Bu ilişki toksik nodüler guatr (TNG) ve toksik multinodüler guatrlı (TMNG) hastalarda araştırılmamıştır. Biz, TNG ve TMNG'li hastalarda, tiroid kanseri ile TRAb arasındaki ilişkiyi araştırmayı amaçladık. Materyal ve Metot: TNG ve TMNG nedeniyle tiroidektomi olan hastalar retrospektif olarak değerlendirildi. Toplam 370 hastadan, TRAb düzeyi mevcut olan 191 TMNG ve 30 TNG hastası çalışmaya dahil edildi. Bulgular: 221 TNG/TMNG'li hastanın 24'ünde (%10,86) TRAb pozitif bulundu. Histopatolojik değerlendirmede, 71 (%32,13) hasta malign, 150 (%67,87) hasta benigndi. 71 malign hastanın 7'sinde (%9,86) ve 150 benign hastanın 17'sinde (%11,33) TRAb pozitifti (p=0,742). Yaş, cinsiyet, serum tirotropin, serbest triiodotironin, serbest tiroksin düzeyleri, anti-tiroid peroksidaz ve anti-tiroglobulin antikor pozitifliği ile histopatolojik tümör tipi açısından TRAb pozitif ve negatif hastalar arasında fark yoktu (sırasıyla p=0,393, p=0,401, p=0,403, p=0,903, p=0,877, p=0,788, p=0,540 ve p=0,357). TRAb pozitif 7 (%29,17) hastada ve TRAb negatif 57 (%28,93) hastada papiller tiroid kanseri (PTK) saptandı (p=0,357). Klasik varyant PTK, TRAb pozitif 5 (%71,43) hastada ve TRAb negatif 50 (%87,72) hastada mevcuttu (p=0,242). Sonuç: Bu çalışmada, TMNG/TNG'li hastalarda TRAb pozitifliğinin malignite riskini artırmadığı görüldü.

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“…While there are many factors that contribute to the carcinogenesis of the thyroid gland, TSH is considered a key cancer growth factor for thyroid cancer. 8 9…”

Section: Introductionmentioning

confidence: 99%

The Difference in Thyroid Stimulating Hormone Levels between Differentiated Carcinoma and Benign Enlargement

Rianto

Wibowo

Herdini

2019

Int Arch Otorhinolaryngol

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Introduction Papillary and follicular thyroid carcinoma are common head and neck cancers. This cancer expresses a thyroid stimulating hormone (TSH) receptor that plays a role as a cancer stimulant substance. This hormone has a diagnostic value in the management of thyroid carcinoma. Objective The present study aimed to determine the difference in TSH levels between differentiated thyroid carcinoma and benign thyroid enlargement. Methods The present research design was a case-control study. The subjects were patients with thyroid enlargement who underwent thyroidectomies at the Dr. Sardjito General Hospital, Yogyakarta, Indonesia. Thyroid stimulating hormone levels were measured before the thyroidectomies. The inclusion criteria for the case group were: 1) differentiated thyroid carcinoma, and 2) complete data; while the inclusion criteria for the control group were: 1) benign thyroid enlargement, and 2) complete data. The exclusion criteria for both groups were: 1) patients suffering from thyroid hormone disorders requiring therapy before thyroidectomy surgery, 2) patients receiving thyroid suppression therapy before the thyroidectomy was performed, and 3) patients suffering from severe chronic diseases such as renal insufficiency, and severe liver disease. Results There were 40 post-thyroidectomy case group patients and 40 post-thyroidectomy control group patients. There were statistically significant differences in TSH levels between the groups with differentiated thyroid carcinoma and benign thyroid enlargement ( p = 0.001; odds ratio [OR] = 8.42; 95% confidence interval [CI]: 3.19–36.50). Conclusion Based on these results, it can be concluded that there were significant differences in TSH levels between the groups with differentiated thyroid carcinoma and benign thyroid enlargement.

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Thyroid malignancy risk in different clinical thyroid diseases

Cited by 12 publications

References 35 publications

Evaluation of ultrasonographical and cytological features of thyroid nodules in patients treated with radioactive iodine for hyperthyroidism

Evaluation of ultrasonographical and cytological features of thyroid nodules in patients treated with radioactive iodine for hyperthyroidism

Thyrotrophin receptor antibody is not associated with thyroid cancer in patients with toxic nodular and multinodular goiter

The Difference in Thyroid Stimulating Hormone Levels between Differentiated Carcinoma and Benign Enlargement

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