Thyroid Lipomatosis

Gönülalan, Gülsüm; Esen, Hasan; Erikoğlu, Mehmet; Çakır, Mehtap

doi:10.2169/internalmedicine.51.6765

Cited by 7 publications

(13 citation statements)

References 8 publications

(9 reference statements)

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“…Our patient showed amyloid deposits, which had been previously reported in two patients with secondary amyloidosis associated with chronic renal failure and hemodialysis in one case, and with Crohn's disease and kidney transplant in the other (7, 13). Two other reports describe amyloid goiters with diffuse infiltration by adipose tissue (14, 15).…”

Section: Discussionsupporting

confidence: 79%

“…Physical examination usually shows a soft, non-tender goiter that is nodular or diffuse (7). In most cases, tests show normal thyroid function, but both hyperthyroidism and hypothyroidism have been described in a few patients.…”

Section: Discussionmentioning

confidence: 99%

“…FNA cytology can suggest a diagnosis of thyroid lipomatosis because it usually describes the presence of abundant fat cells among normal follicular cells (7). Although there are no clear guidelines to establish a diagnosis of thyroid lipomatosis with this method, the cytological findings are specific enough to exclude anaplastic carcinoma and thyroid lymphoma (9).…”

Section: Discussionmentioning

confidence: 99%

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Thyroid lipomatosis in a 36-year-old patient with rheumatoid arthritis and a kidney transplant

Bell

Sosa

Jaén

et al. 2016

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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SummaryThyroid lipomatosis is a rare disease, as a total of 20 cases have been described in the literature. It is characterized by diffuse infiltration of the stroma by mature adipose tissue and by progressive growth that produces different degrees of compressive symptoms. Our aim is to present the case of a 36-year-old woman who consulted because of dyspnea caused by a multinodular goiter. She underwent surgery with the presumptive diagnosis of a malignant neoplasia, but the pathological examination of the surgical specimen established the diagnosis of thyroid lipomatosis.Learning points Thyroid lipomatosis is a rare, benign disease characterized by diffuse infiltration of the stroma by mature adipose tissue.The pathophysiology of diffuse proliferation of adipose tissue in the thyroid gland is unclear.Thyroid lipomatosis is clinically manifested by a progressive enlargement of the thyroid that can involve the airway and/or upper gastrointestinal tract, producing dyspnea, dysphagia, and changes in the voice.Given the rapid growth of the lesion, the two main differential diagnoses are anaplastic carcinoma and thyroid lymphoma.Imaging studies may suggest a differential diagnosis, but a definitive diagnosis generally requires histopathological confirmation after a thyroidectomy.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Thyroid lipomatosis in a 36-year-old patient with rheumatoid arthritis and a kidney transplant

Bell

Sosa

Jaén

et al. 2016

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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“…Radiological studies were not diagnostic, but the ultrasound may reveal enlargement of the thyroid with diffuse increase in the echogenicity and attenuation of sound typical of fat [10], Computerized tomography of the thyroid may reveal low attenuation components with negative Hounsfield units [11].…”

Section: Discussionmentioning

confidence: 99%

Diffuse Lipomatosis of Thyroid—Case Report

Jahid¹,

Amine²,

Chad³

2018

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Diffuse lipomatosis of thyroid gland is very rare disease, characterized by diffuse proliferation of adipose tissue in the thyroid gland, the pathophysiology of adipose tissue infiltration in the thyroid gland remains unknown. We report a case of a 55-year-old female who presented 6 months ago a dysphonia, ultrasound of the neck revealed the presence diffuse goiter with heterogeneous echogenicity, her thyroid hormone levels were normal, thyroid isotope scanning showed heterogeneous uptake of radioactivity and coexistence of cold and hot nodules. The patient underwent total thyroidectomy. Histological study concluded to the diagnosis of diffuse lipomatosis of thyroid gland.

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“…Şeffaf hücreli adenomlarda, folliküler hücreler küçük oval nükleuslu geniş köpüksü veya vakuolize sitoplazma ile karakterizedir. Böyle durumlarda tiroglobulin kullanılarak tiroid folliküler hücrelerinin orjini tespit edilebilir [2,17,18].…”

Section: Discussionunclassified