Thyroid-imipramine clinical and chemical interaction: Evidence for a receptor deficit in depression

Prange, Arthur J.; Wilson, Ian C.; Knox, Angelina E.; McClane, T.K.; Breese, George R.; Martin, Billy R.; Alltop, Lacoe B.; Lipton, Morris A.

doi:10.1016/0022-3956(72)90020-9

Cited by 67 publications

(7 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two separate studies noted antidepressant effects occurring within hours after intravenous administration of a single dose of TRH in subjects with MDD, an improvement that persisted for three days [105,106]. However, other studies failed to replicate these initial findings [107,108,109].…”

Section: Pharmacological and Non-pharmacological Approaches And Thmentioning

confidence: 99%

The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments

et al. 2010

View full text Add to dashboard Cite

Currently available antidepressants used to treat major depressive disorder (MDD) unfortunately often take weeks to months to achieve their full effects, commonly resulting in considerable morbidity and increased risk for suicidal behavior. Our lack of understanding of the precise cellular underpinnings of this illness and of the mechanism of action of existing effective pharmacological treatments is a large part of the reason that therapies with a more rapid onset of antidepressant action (ROAA) have not been developed. Other issues that need to be addressed include heterogeneous clinical concepts and statistical models to measure rapid antidepressant effects. This review describes the timing of onset of antidepressant effects for various therapies used to treat MDD. While several agents produce earlier improvement of depressive symptoms (defined as occurring within one week), the response rate associated with such agents can be quite variable. These agents include both currently available antidepressants as well as other pharmacological and non-pharmacological interventions. Considerably fewer treatments are associated with ROAA, defined as occurring within several hours or one day. Treatment strategies for MDD whose sustained antidepressant effects manifest within hours or even a few days would have an enormous impact on public health.

show abstract

Section: Pharmacological and Non-pharmacological Approaches And Thmentioning

confidence: 99%

The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Two independent investigators have reported that TRF may function as an antidepressant agent independent of its hormonal role. Like thyroid hormone and TSH, the tripeptide TRF appears to potentiate imipramine (6)(7)(8)(9). With the exception of its effect on prolactin, TRF is specific and does not appear to effect secretion of other pituitary hormones.…”

Section: Discussionmentioning

confidence: 99%

Amenorrhea in Endogenous Depression

Ossofsky¹

1974

Int Pharmacopsychiatry

View full text Add to dashboard Cite

Five patients are presented in whom reproductive abnormalities and depression were both reversed with imipramine. Although much clinical and experimental work lies ahead before the relationship of hypothalamic hormones and depression is understood, current research pertaining to hypothalamic releasing factors provides many clues which fit quite well with both clinical observations and current theories regarding a neuroendocrinological pathogenesis of depression.

show abstract

“…As TRH has lost two protons from two amide functional groups, we denote the complex as Cu(II)-TRH(H À2 )(H 2 O). TRH has been shown to improve functional recovery after neurologic dysfunctions, such as brain trauma and epilepsy, in both humans and animals such as rats, mice and cats [21][22][23][24][25]. We believe that, coupled with online microdialysis and preconcentration, the concentration of TRH can be monitored.…”

Section: Introductionmentioning

confidence: 93%

The rotating ring-disk electrochemistry of the copper(II) complex of thyrotropin-releasing hormone

Rong

Weber

2007

Journal of Electroanalytical Chemistry

View full text Add to dashboard Cite

Thyrotropin-releasing Hormone (TRH) forms an electroactive Cu(II) complex in aqueous solution. Rotating ring-disk electrochemistry reveals oxidation at the disk electrode and reduction at the ring electrode. The plot of limiting current vs. square root of rotation frequency deviates from the Levich equation, indicating both preceding and following chemical reactions. The reaction following the oxidation is a multiple-electron ECE-type of process that has been seen before in Cu(II)-peptide electrochemistry. The preceding reaction is unusual. The deviation from diffusion-controlled behavior is more pronounced at higher initial concentration of Cu(II) and peptide. We propose that a non-electroactive dimer, Cu(II)(2)-TRH(2), is in a slow equilibrium with the electroactive Cu(II)-TRH. Simulation of the RRDE behavior of the postulated Cu(II)-TRH system has succeeded in matching experimental data. Capillary electrophoresis indicates that there is a negative charge on the dimer. It is suggested that a hydroxo-bridge may link the two Cu(II) centers. Calculations verify that bi-nuclear Cu(II)(2)-TRH(2) complexes are possible.

show abstract

Thyroid-imipramine clinical and chemical interaction: Evidence for a receptor deficit in depression

Cited by 67 publications

References 41 publications

The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments

The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments

Amenorrhea in Endogenous Depression

The rotating ring-disk electrochemistry of the copper(II) complex of thyrotropin-releasing hormone

Contact Info

Product

Resources

About