Thyroid Imaging Reporting and Data System for US Features of Nodules: A Step in Establishing Better Stratification of Cancer Risk

Kwak, Jin Young; Han, Kyunghwa; Yoon, Jung Hyun; Moon, Hee Jung; Son, Eun Ju; Park, So Hee; Jung, Hyun Hwan; Choi, Ji Soo; Kim, Bo Mi; Kim, Min Jung

doi:10.1148/radiol.11110206

Cited by 938 publications

(1,107 citation statements)

References 28 publications

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“…All nodules were evaluated and classified according to the presence of 20 predefined ultrasound features, mostly retrieved from a literature review (4,5,(7)(8)(9)(10)(11)21,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34) and detailed in Table 1. These features were included in a multiple logistic regression analysis to determine whether they were (or not) independently associated with the likelihood of malignancy (4,5,(8)(9)(10)(11)(24)(25)(26)(28)(29)(30)34).…”

Section: Thyroid Ultrasound and Fnab Evaluationsmentioning

confidence: 99%

“…These features were included in a multiple logistic regression analysis to determine whether they were (or not) independently associated with the likelihood of malignancy (4,5,(8)(9)(10)(11)(24)(25)(26)(28)(29)(30)34). Among all ultrasound features, 13 were likely to be associated with malignancy, as previously described: (i) solid appearance, (ii) …”

Section: Thyroid Ultrasound and Fnab Evaluationsmentioning

confidence: 99%

“…Several authors (7)(8)(9)(10)(11)(12) have proposed different Thyroid Imaging Reporting and Data System (TI-RADS) classifications to standardize thyroid ultrasound reports, as demonstrated with the Breast Imaging Reporting and Data System (BI-RADS ® ) (13). Researchers have recently attempted to validate this type of approach as an instrument for use in clinical practice, with some authors proposing different TI-RADS versions in selected populations (14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

“…The TI-RADS proposed by Kwak and cols. (9) was based on a practical and simplified scoring system to identify suspicious findings; each feature received identical weight in the proposed score, and higher scores were attributed to the occurrence of more than one suspicious ultrasound feature in the same nodule.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Likelihood of malignancy in thyroid nodules according to a proposed Thyroid Imaging Reporting and Data System (TI-RADS) classification merging suspicious and benign ultrasound features

Delfim

Veiga

Vidal

et al. 2017

Arch. Endocrinol. Metab.

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Objective: The aim of this study was to describe the ultrasound features of benign and malignant thyroid nodules and evaluate the likelihood of malignancy associated with each feature according to the Bethesda System for Reporting Thyroid Cytopathology and histopathology. With this analysis, we propose a new TI-RADS classification system. Materials and methods: The likelihood of malignancy from ultrasound features were assessed in 1413 thyroid nodules according to the Bethesda System for Reporting Thyroid Cytopathology and histopathological findings. A score was established by attributing different weights to each ultrasound feature evaluated. Results: Features positively associated with malignancy in bivariate analysis received a score weight of +1. We attributed a weight of +2 to features which were independently associated with malignancy in a multivariate analysis and +3 for those associated with the highest odds ratio for malignancy (> 10.0). Hence, hypoechogenicity (graded as mild, moderate or marked, according to a comparison with the overlying strap muscle), microcalcification and irregular/microlobulated margin received the highest weights in our scoring system. Features that were negatively associated with malignancy received weights of -2 or -1. In the proposed system a cutoff score of 2 (sensitivity 97.4% and specificity 51.6%) was adopted as a transition between probably benign (TI-RADS 3) and TI-RADS 4a nodules. Overall, the frequency of malignancy in thyroid nodules according to the categories was 1.0% for TI-RADS 3, 7.8% for TI-RADS 4a, 35.3% for TI-RADS 4b, and 84.7% for TI-RADS 5. Conclusion: A newly proposed TI-RADS classification adequately assessed the likelihood of malignancy in thyroid nodules. Arch Endocrinol Metab. 2017;61(3):211-21.

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Section: Thyroid Ultrasound and Fnab Evaluationsmentioning

confidence: 99%

Section: Thyroid Ultrasound and Fnab Evaluationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Likelihood of malignancy in thyroid nodules according to a proposed Thyroid Imaging Reporting and Data System (TI-RADS) classification merging suspicious and benign ultrasound features

Delfim

Veiga

Vidal

et al. 2017

Arch. Endocrinol. Metab.

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“…The following US features showed a significant association with malignancy: solid component, hypoechogenicity, marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, and taller-than-wide shape [11].…”

Section: Thyroid Gland Thyroid Nodulesmentioning

confidence: 98%

Thyroid Ultrasound: State of the Art Part 1 – Thyroid Ultrasound reporting and Diffuse Thyroid Diseases

et al. 2017

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Accurate differentiation of focal thyroid nodules (FTL) and thyroid abnormalities is pivotal for proper diagnostic and therapeutic work-up. In these two part articles, the role of ultrasound techniques in the characterization of FTL and evaluation of diffuse thyroid diseases is described to expand on the recently published World Federation in Ultrasound and Medicine (WFUMB) thyroid elastography guidelines and review how this guideline fits into a complete thyroid ultrasound exam.

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Understanding the Risks and Harms of Management of Incidental Thyroid Nodules

Hoang

Nguyen

2017

JAMA Otolaryngol Head Neck Surg

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Thyroid Imaging Reporting and Data System for US Features of Nodules: A Step in Establishing Better Stratification of Cancer Risk

Abstract: Risk stratification of thyroid malignancy by using the number of suspicious US features allows for a practical and convenient TIRADS.

Cited by 938 publications

References 28 publications

Likelihood of malignancy in thyroid nodules according to a proposed Thyroid Imaging Reporting and Data System (TI-RADS) classification merging suspicious and benign ultrasound features

Likelihood of malignancy in thyroid nodules according to a proposed Thyroid Imaging Reporting and Data System (TI-RADS) classification merging suspicious and benign ultrasound features

Thyroid Ultrasound: State of the Art Part 1 – Thyroid Ultrasound reporting and Diffuse Thyroid Diseases

Understanding the Risks and Harms of Management of Incidental Thyroid Nodules

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