Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension

Jankauskas, Stanislovas S.; Morelli, Marco Bruno; Gambardella, Jessica; Lombardi, Angela; Santulli, Gaetano

doi:10.1111/jch.14152

Cited by 14 publications

(8 citation statements)

References 100 publications

(201 reference statements)

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“…Our results agreed with that of Walsh et al [ 37 ] who reported increased frequency of HTN among patients with SCH and Kaminski et al [ 14 ] who performed 24 h ambulatory BP monitoring for patients with SCH and found a higher nocturnal mean systolic and diastolic BP and higher mean BP compared to euthyroid controls. High BP in patients with SCH can be explained by the elevated CO and the increased blood volume [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Renal function changes in patients with subclinical hyperthyroidism: a novel postulated mechanism

Allam,

El-Zawawy,

El-Zawawy

2023

Endocrine

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Background Subclinical hyperthyroidism (SCH) is found to be associated with renal dysfunction. Hyperthyroidism is a well-known cause of secondary systolic hypertension. However, the effect of SCH on the kidney and its vasculature is still unknown. Aim To assess the presence of renal function changes and renal vasodysfunction in SCH patients and their relation to hypertension. Methods The study included 321 patients with SCH and 80 healthy matched controls. Laboratory investigations included thyroid function tests, anti-TSH receptor antibody (TRAb), creatinine, estimated glomerular filtration rate (eGFR), serum osmolarity (S. Osmol), urine osmolarity (U. Osmol), Fractional Excretion of Sodium (FeNa), Fractional Excretion of Potassium (FeK), copeptin (CPP), and aldosterone/renin ratio (ARR). Ultrasound for the thyroid gland, echocardiography, total peripheral resistance (TPR), flow-mediated dilatation (FMD), and Renal Arterial distensibility (RAD) was also done. Results Serum creatinine was significantly lower while eGFR was significantly higher in SCH patients compared to euthyroid subjects (mean 0.59 ± 0.11 mg/dl Vs mean 0.8 ± 0.1 mg/dl, p = 0.001 and mean 128.28 ± 14.69 ml/min/1.73m2 Vs mean 100.49 ± 14.9 ml/min/1.73m2, p = 0.013, respectively). The TPR and FMD showed a significant decrease in SCH group compared to controls (mean 975.85 ± 159.33 mmHg.min/L Vs mean 1120.24 ± 135.15 mmHg.min/L, p = 0.045 and mean 7.03 ± 4.02% Vs mean 13.48 ± 4.57%, p = 0.003, respectively). RAD was significantly higher in hypertensive SCH patients compared to normotensive SCH patients (mean 17.82 ± 2.46 mmHg Vs mean 11.98 ± 3.21 mmHg, p = 0.001). Conclusion SCH patients showed vascular resistance reduction. Alterations in thyroid hormones and blood pressure could be the driving mechanisms for the change in renal functions in patients with SCH.

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Section: Discussionmentioning

confidence: 99%

Renal function changes in patients with subclinical hyperthyroidism: a novel postulated mechanism

Allam,

El-Zawawy,

El-Zawawy

2023

Endocrine

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“…Conversely, thyroxine has positive time-varying and force-varying cardiac effects. Hypothyroidism weakens these effects, resulting in a reduce cardiac output and renal blood flow, indirectly damaging renal tissue [ 14 ]. Meanwhile, NS may also induce hypothyroidism owing to the loss of hormone-binding proteins.…”

Section: Discussionmentioning

confidence: 99%

Minimal change disease with papillary thyroid carcinoma: a report of two adult cases

Yin

Hao

et al. 2023

BMC Nephrol

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Background Minimal change disease (MCD), a pathological type of nephrotic syndrome (NS), can occur in patients with tumors. We report two adult cases of MCD associated with papillary thyroid carcinoma (PTC), known to be extremely rare in adults. Case presentation A 35-year-old female patient was simultaneously diagnosed with MCD and PTC. The MCD was effectively treated with thyroidectomy and prednisone.In addition, a 50-year-old male patient, who had been diagnosed with PTC three years prior, had MCD confirmed by renal biopsy. The patient achieved complete remission following treatment with tacrolimus and rituximab. Conclusions The present case report describes and discusses the diagnostic and treatment processes employed in these two patients. Clinicians need to be aware of the renal effects of treating patients with solid tumors.

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“…If these critical factors affecting lipid levels are not considered, the connection between TSH and lipid profile seems dubious. We established a substantial connection between TSH and lipid markers in this research even after adjusting for thyroid hormone effects [ 17 ]. Throughout the normal and high TSH ranges, we found a significant positive connection between serum TSH, ALT, and AST activities, as well as a similar inverse correlation between FT4 and serum liver enzyme activity concentrations.…”

Section: Discussionmentioning

confidence: 99%

Biochemical changes in patients during hypothyroid phase after thyroidectomy

2022

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Hypothyroidism is the most common long-term consequence after total thyroidectomy. The objective of the present study was to evaluate the lipid profile and liver function in patients after hypothyroidism. Sixty patients who underwent a surgical operation to remove thyroid were included in this study, and thirty healthy subjects were used as a control. The study was conducted at Al-Sadr Medical City in Al-Najaf city, in Iraq, from October 2020 to March 2021. Thyroid-stimulating hormone (TSH) was very high in patients at a hypothyroid stage after hypothyroidism. The results showed a significant increase in total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), and the ratio of total cholesterol/high-density lipoprotein (HDL). The study also revealed a significant increase in the liver enzymes aspartate aminotransferase (AST) and alanine transaminase (ALT) and a significant decrease in alkaline phosphatase (ALP) in patients with thyroidectomy compared to the control group. The correlation matrix revealed a strong positive correlation between TSH levels and total cholesterol, triglycerides, LDL, AST, ALT, and ALP. It was concluded that hypothyroidism, the major consequence of thyroidectomy, causes dysfunction in lipid metabolism and liver enzymes resulting in secondary hyperlipidemia and liver dysfunction.

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Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension

Cited by 14 publications

References 100 publications

Renal function changes in patients with subclinical hyperthyroidism: a novel postulated mechanism

Renal function changes in patients with subclinical hyperthyroidism: a novel postulated mechanism

Minimal change disease with papillary thyroid carcinoma: a report of two adult cases

Biochemical changes in patients during hypothyroid phase after thyroidectomy

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