Thyroid Hormones in Male Reproduction and Fertility

Rajender, Singh; Hamada, Alaa; Agarwal, Ashok

doi:10.2174/1874255601103010098

Cited by 35 publications

(3 citation statements)

References 65 publications

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“…In the PTU group, the decrease in sperm count, motility, and viability, as well as a significant increase in sperm abnormality indicates impact of hypothyroidism on spermatogenesis; this finding was consistent with previous studies (Sahoo et al., 2008 ; Wang et al., 2015 ). These findings were attributed to the drop in thyroid hormone which is a crucial mediator for germ cell differentiation and maturation (Singh et al., 2011 ), together with the decrement of the sex hormones (Capel, 2000 ; Kerr et al., 2006 ), in addition to oxidative stress that impacts sperm cells' motility and genetic integrity (Iommiello et al., 2015 ). However, in the PTU+ Se group, there was no impairment of spermatogenesis, due to the normal testosterone levels and the antioxidant impact of Se on Leydig cells, which improves their responsiveness to LH, this was in harmony with Owumi et al.…”

Section: Discussionmentioning

confidence: 99%

Selenium protects against nesfatin‐1 modulation of the hypothalamic‐pituitary‐testicular axis during hypothyroidism in male rats

El‐Shaer,

Ibrahim,

Hewady

et al. 2024

Physiological Reports

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Normal gonadal function can be disrupted by hypothyroidism. Hypothyroidism disturbs testicular function directly and centrally by affecting the hypothalamic‐pituitary‐testicular axis with unclear mechanism. As nesfatin‐1 neurons co‐localized with TRH and GnRH neurons in the hypothalamus, it could play a role in centrally hypothyroidism induced testicular dysfunction. Selenium (Se), by affecting thyroid iodide supply, could relieve these disturbances. So, we aim to identify the role of nesfatin‐1 as a link between testicular dysfunction and hypothyroidism through modulating the MAPK/ERK pathway while discussing the possible role of Se in alleviating hypothyroidism and associated testicular damage. Forty male rats were divided equally into: Control: distilled water, Se: Se orally, Propylthiouracil (PTU): PTU orally, PTU + Se: Se with PTU orally. Serum thyroid function, gonadal hormones, nesfatin‐1, testicular redox status, sperm analysis, brain tissue GnRH, nucleobindin 2‐derived polypeptide, pMAPK/ERK gene expression, histological changes and immunohistochemical expression of testicular proliferating cell antigen (PCNA) were done. PTU induced hypothyroidism and reduction of gonadal hormones which both were correlated with reduced nesfatin‐1. There was testicular stress with reduced GnRH, NUCB2, pMAPK/ERK gene expression, and PCNA immunopositive cells. These parameters were reversed by Se. Nesfatin‐1 could be the central link between hypothyroidism and disturbances of the hypothalamic pituitary testicular axis.

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Section: Discussionmentioning

confidence: 99%

Selenium protects against nesfatin‐1 modulation of the hypothalamic‐pituitary‐testicular axis during hypothyroidism in male rats

El‐Shaer,

Ibrahim,

Hewady

et al. 2024

Physiological Reports

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“…This is free-and albuminbound portions testosterone which is called as bio available testosterone [8, 19,53]. It has been reported that in hyperthyroidism, total testosterone and SHBG levels are increased [23,37] and free Testosterone is transiently reduced or may be within normal range [22] but mean basal bio-available Testosterone level is decreased [50]. In few thyrotoxic male subjects elevated circulating estrogen level have been reported…”

Section: Discussionmentioning

confidence: 99%

Impact of Radio Frequency Radiation (RFR) emitted from Cell Phone on Human Semen Quality

Singh,

Trivedi

et al. 2024

Preprint

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A prospective study has been conducted to find out the impact of cell phone on the semen quality and hormonal profile of the men. After fulfilling the exclusion and inclusion criteria 421 healthy male volunteer’s aged 18–45 years were divided in to three groups depending on duration of cell phone use. Group-1 highly exposed group, Group-2 moderately exposed group, Group-3 control group. Subjects were asked to visit clinic every year for semen and blood sample collection up to three years. Semen physical characteristics and blood testosterone, T4 and TSH levels were estimated. Semen volume, rapid forward linear progression motility, moderate linear progression motility, sperm concentration, sperm density, percentage of normal and live sperm decreased in Group-1 in comparison to Groups-2 & 3 and trend continued till 3rd year. Sperm head abnormalities were higher in Group-1 than the Groups − 2 & 3 and trend continued till 3rd year. Slight decrease in levels of testosterone, significant increase in T4 and decrease in TSH were observed in Group-1 and similar trend was noticed till 3rd year. Present data indicate that the increased duration of cell phone use is adversely influencing the semen quality and hormone levels in men which may lead to infertility.

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“…Вивчені декілька шляхів, що пов'язують метаболічні порушення в чоловіків з гіпотиреозом зі змінами найважливіших потенційних маркерів чоловічої фертильності, зокрема параметрами спермограми або профілю репродуктивних гормонів [5,6]. Дослідження останніх років чітко показують вплив гіпотиреозу на профіль репродуктивних гормонів у чоловіків, що насамперед характеризується зниженням рівня тестостерону і сексзв'язуючого глобуліну в периферичній крові [7].…”

Section: вступunclassified

Primary hypothyroidism as a predictor of the hypogonadism development

Pasyechko

Krytskyi

Kadubets

et al. 2022

Mìžnarodnij endokrinologìčnij žurnal

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Background. Human lifestyle significantly affects human health and reproductive functions. The presence of hypothyroidism negatively impacts the health, activity, and reproductive status. This study was aimed to assess hormonal status, metabolic and anthropometric parameters in men of active reproductive age with primary hypothyroidism. Materials and methods. Totally 60 males with primary hypothyroidism were included in the study. A comparative analysis of hormonal, anthropometric, and metabolic parameters in 60 men with hypothyroidism (basic group) and 25 men without hypothyroidism and other chronic somatic diseases (control group) was performed. The mean age of the subjects was 42.4 ± 2.7 years. Results. It has been established that hypothyroidism was accompanied by an increase in serum concentrations of cholesterol and low-density lipoprotein cholesterol in comparison with control group (25 men without hypothyroidism) indicating metabolic disturbance. The data shows the significant effect of hypothyroidism on testosterone and follicle-stimulating hormone (FSH) serum concentration but not on luteinizing hormone, estradiol levels. Patients with hypothyroidism had lower circulating testosterone and higher FSH level in comparison with the controls. The reproductive hormone changes in men with hypothyroidism can result in deleterious effects on sexual functions including erectile dysfunction, reduced libido, and alteration in spermatogenesis. Conclusions. In men with hypothyroidism, changes in hormonal status have been found, which manifested in a decrease in testosterone and an increase in the blood level of follicle-stimulating hormone. The effect of hypothyroidism on the blood level of other hormones (luteinizing, estradiol, cortisol) has not been established. Hypothyroidism in men is accompanied by changes in lipid metabolism (increased levels of total cholesterol and low-density lipoprotein cholesterol).

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Thyroid Hormones in Male Reproduction and Fertility

Cited by 35 publications

References 65 publications

Selenium protects against nesfatin‐1 modulation of the hypothalamic‐pituitary‐testicular axis during hypothyroidism in male rats

Selenium protects against nesfatin‐1 modulation of the hypothalamic‐pituitary‐testicular axis during hypothyroidism in male rats

Impact of Radio Frequency Radiation (RFR) emitted from Cell Phone on Human Semen Quality

Primary hypothyroidism as a predictor of the hypogonadism development

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