Thyroid Hormones and Spermatozoa: In Vitro Effects on Sperm Mitochondria, Viability and DNA Integrity

Condorelli, Rosita A.; Vignera, Sandro La; Mongioì, Laura M.; Alamo, Angela; Giacone, Filippo; Cannarella, Rossella; Calogero, Aldo E.

doi:10.3390/jcm8050756

Cited by 17 publications

(18 citation statements)

References 22 publications

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“…Therapeutic issues are also addressed in this Special Issue. These include the effectiveness of L-acetyl-carnitine for the treatment of asthenozoospermia in patients with type I diabetes mellitus [8] and the in vitro effects of thyroid hormones in sperm mitochondrial function, viability, and DNA integrity [9].…”

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confidence: 99%

Disorders of Puberty: Endocrinology of the Pre-Pubertal Testis

Vignera

Cannarella

Condorelli

et al. 2020

JCM

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Male infertility is a widespread condition among western countries. Meta-regression data show that sperm concentration and total sperm count have halved in the last decades. The reasons of this decline are still unclear. The evaluation of testicular function in pre-pubertal children may be effective in the timely detection of Sertoli cell (SC) disfunction, which anticipates the diagnosis of male infertility. The aim of this Special Issue is to gather together in vitro evidence on SC physiology, causes of SC dysfunction, and to suggest a practical approach to be adopted in children.

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confidence: 99%

Disorders of Puberty: Endocrinology of the Pre-Pubertal Testis

Vignera

Cannarella

Condorelli

et al. 2020

JCM

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“…Many aspects of the possible role of thyroid hormones are yet to be clarified in the dog, by taking also into account their involvement on the reproductive performance. To date, all in vitro researches were performed on animal models, and recently in vitro effects of thyroid hormones on sperm mitochondria, viability and DNA integrity were studied in humans (Condorelli et al 2019).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, fT 4 seems to have a potential protective effect, being inversely correlated with sperm DNA damage in men (Meeker et al 2008). In human, the in vitro effects of levothyroxine on conventional and bio-functional sperm parameters on male fertility were recently assessed, clarifying the involvement of thyroid function on fertility (Condorelli et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Correlation between sperm parameters and circulating thyroid hormones and testosterone concentrations in Labrador Retriever dog

Quartuccio

Fazio

Medica

et al. 2021

Italian Journal of Animal Science

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Thyroid hormones physiologically regulate the semen quality, by altering testosterone concentrations, and different seminal parameters, as well as sperm motility, viability and semen volume. Serum thyroxine (T 4 ), free thyroxine (fT 4 ), thyroid-stimulating hormone (TSH) and testosterone (T) concentrations were measured in 26 adult Labrador Retriever dogs (n. 20 normospermic and n. 6 azoospermic groups), aged 3 ± 0.5 years old, to determine their specific references, by taking into account the related conventional and kinematic sperm parameters and clinical ultrasound evaluations. The mean values of T 4 , fT 4 , TSH and T concentrations, as soon as those of sperm parameters and clinical evaluations of normospermic group were in line with dog's physiological range of literature data. Normospermic group showed significant correlations between T 4 and T (r ¼ À0.681; p < .01), sperm progressive motility (%) (r ¼ À0.623; p < .01), and sperm non-progressive motility (%) (r ¼ 0.625; p < .02). The azoospermic group showed higher T 4 , fT 4 , TSH and lower T concentrations, compared to normospermic group, and a positive correlation between T 4 and T (r ¼ 0.8548; p < .046). The use of breed-specific hormonal ranges and sperm parameters will improve the knowledge of their interaction in Labrador Retriever dogs, adding a new segment of scientific literature. HIGHLIGHTSThyroxine (T 4 ), free thyroxine (fT 4 ), thyroid stimulating hormone (TSH) and testosterone (T) concentrations were measured in male dogs. Conventional and kinematic sperm parameters were also evaluated. Dogs were divided in 20 normospermic and n. 6 azoospermic Labrador Retrivers. Azoospermic group showed higher values of T 4 , fT 4 , TSH and lower values of T compared to normospermic Use of breed-specific hormonal ranges and sperm parameters will improve the knowledge of scientific literature.

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“…Studies in the rat have shown that hypothyroidism causes arrest of spermatogenesis. [ 12 ] In humans, similar studies done till now are heterogeneous, with regards to the number of patients included, the way semen analysis was reported, and whether the posttreatment effect was analyzed or not. Studies on the effect of hypothyroidism on semen parameters done till now show a negligible effect of hypothyroidism on semen volume, except one by Corrales et al ., where a statistically significant difference was found in the mean semen volume between patients and controls (2.7 ± 1.4 vs. 3.7 ± 1.2).…”

Section: Discussionmentioning

confidence: 99%

Effect of thyroxine replacement on leydig cell and sertoli cell function in men with hypothyroidism

Ambigapathy

Kamalanathan

Sahoo

et al. 2020

Indian J Endocr Metab

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Context: Thyroid hormones play an important role in reproductive and sexual function in both sexes. Comprehensive information on the ill-effects of hypothyroidism on Leydig cell, Sertoli cell and germ cell function is lacking in the existing literature. Aims: To investigate the effect of primary hypothyroidism and its treatment on testicular function – Sertoli cell, Leydig cells, seminal fluid and spermatozoa. Methods and Material: This study was carried out as a descriptive study with a before-after study design in the endocrine department of a tertiary care hospital in South India. Forty treatment naïve, overtly primary hypothyroid, consenting male patients were included. Hormones assessed were free T3, free T4, thyroid stimulating hormone, follicle stimulating hormone [FSH], luteinizing hormone [LH], prolactin, testosterone, inhibin B[INHB], and insulin like factor 3[INSL3]. Semen analysis was done according to WHO 2010 guidelines in 37 subjects. Sexual function questionnaires like Androgen Deficiency in Aging Male [ADAM], and Arizona Sexual Experience Scale [ASEX] were used. After ensuring euthyroid state for consecutive 6 months with adequate dose of thyroxine sodium, reassessment of all parameters was done. Results: At baseline, 72.5 % had a low serum testosterone value (< 230 ng/dl), 67.56 % had low total sperm motility, 72.97% had low total progressive sperm motility, 80% had low ADAM score and 72.72% had low ASEX score. A raised prolactin level was seen in 32.5% of study subjects. Hypogonadotropic hypogonadism was more common than hypergonadotropic hypogonadism (89.66% vs. 10.34%). On restoration of euthyroidism, all these parameters improved. Serum INSL3 and LH increased significantly after thyroxine replacement, unlike FSH and INHB. Conclusions: Leydig cell function seemed more severely affected by hypothyroidism as compared to Sertoli cell function. Among sperm function parameters, motility was predominantly affected.

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Thyroid Hormones and Spermatozoa: In Vitro Effects on Sperm Mitochondria, Viability and DNA Integrity

Cited by 17 publications

References 22 publications

Disorders of Puberty: Endocrinology of the Pre-Pubertal Testis

Disorders of Puberty: Endocrinology of the Pre-Pubertal Testis

Correlation between sperm parameters and circulating thyroid hormones and testosterone concentrations in Labrador Retriever dog

Effect of thyroxine replacement on leydig cell and sertoli cell function in men with hypothyroidism

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