2008
DOI: 10.14310/horm.2002.1111035
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Thyroid hormones and aging

Abstract: With an increase in age, marked changes in thyroid hormone production, metabolism, and action occur. This results in an increased prevalence of (subclinical) thyroid disease in the elderly. In general, subclinical thyroid disease is associated with an increased risk of overt thyroid dysfunction and with different negative clinical parameters. In the elderly, however, it is unclear whether these changes represent physiologic changes in thyroid hormone levels with advancing age or whether they represent true (su… Show more

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Cited by 80 publications
(50 citation statements)
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References 81 publications
(119 reference statements)
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“…Numerous factors have been observed to have a varying degree of implications on pituitary-thyroid function in old age, rendering the definition of "healthy" old individuals problematic. 17,18 Chronic diseases and drug therapy frequently occurring in the aged, physical activity, nutrition, obesity, smoking and the statistically more disturbing subclinical thyroid diseases obscure the actual impact of aging itself on the thyroid. Consequently, the truth must be sought again in the large numbers (Table 3).…”
Section: The Trh -Tsh -T4 + T3 Axismentioning
confidence: 99%
“…Numerous factors have been observed to have a varying degree of implications on pituitary-thyroid function in old age, rendering the definition of "healthy" old individuals problematic. 17,18 Chronic diseases and drug therapy frequently occurring in the aged, physical activity, nutrition, obesity, smoking and the statistically more disturbing subclinical thyroid diseases obscure the actual impact of aging itself on the thyroid. Consequently, the truth must be sought again in the large numbers (Table 3).…”
Section: The Trh -Tsh -T4 + T3 Axismentioning
confidence: 99%
“…Aging results in significant alterations in thyroid hormone synthesis, metabolism, and action, and the biological activity of thyroidstimulating hormone (TSH) has been observed to decrease with aging (7,8). Possible interactions between thyroid hormones and concomitant treatment may induce significant changes in the HPT axis (7).…”
Section: Introductionmentioning
confidence: 99%
“…Aging results in significant alterations in thyroid hormone synthesis, metabolism, and action, and the biological activity of thyroidstimulating hormone (TSH) has been observed to decrease with aging (7,8). Possible interactions between thyroid hormones and concomitant treatment may induce significant changes in the HPT axis (7). Moreover, fasting and acute or chronic illness are related to the development of non-thyroidal illness, and decreased serum triiodothyronine (T 3 ) levels represent a significant confounder in the assessment of thyroid function with increasing age (7).…”
Section: Introductionmentioning
confidence: 99%
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“…T 3 mediates its major effects by binding to nuclear TH receptors (TRs) which regulate the transcription of target genes (3). Abnormalities in TH status are commonly found among endocrine disorders (4) at varying prevalences according to the group of patients that is being studied (5,6).…”
Section: Introductionmentioning
confidence: 99%