Thyroid hormones and aging

Peeters, Robin P.

doi:10.14310/horm.2002.1111035

Cited by 80 publications

(50 citation statements)

References 81 publications

(119 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Numerous factors have been observed to have a varying degree of implications on pituitary-thyroid function in old age, rendering the definition of "healthy" old individuals problematic. 17,18 Chronic diseases and drug therapy frequently occurring in the aged, physical activity, nutrition, obesity, smoking and the statistically more disturbing subclinical thyroid diseases obscure the actual impact of aging itself on the thyroid. Consequently, the truth must be sought again in the large numbers (Table 3).…”

Section: The Trh -Tsh -T4 + T3 Axismentioning

confidence: 99%

The aging of the endocrine hypothalamus and its dependent endocrine glands

Batrinos¹

2012

View full text Add to dashboard Cite

Section: The Trh -Tsh -T4 + T3 Axismentioning

confidence: 99%

The aging of the endocrine hypothalamus and its dependent endocrine glands

Batrinos¹

2012

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

“…Aging results in significant alterations in thyroid hormone synthesis, metabolism, and action, and the biological activity of thyroidstimulating hormone (TSH) has been observed to decrease with aging (7,8). Possible interactions between thyroid hormones and concomitant treatment may induce significant changes in the HPT axis (7). Moreover, fasting and acute or chronic illness are related to the development of non-thyroidal illness, and decreased serum triiodothyronine (T 3 ) levels represent a significant confounder in the assessment of thyroid function with increasing age (7).…”

Section: Introductionmentioning

confidence: 99%

“…Possible interactions between thyroid hormones and concomitant treatment may induce significant changes in the HPT axis (7). Moreover, fasting and acute or chronic illness are related to the development of non-thyroidal illness, and decreased serum triiodothyronine (T 3 ) levels represent a significant confounder in the assessment of thyroid function with increasing age (7). On the other hand, menopause per se is not directly associated with thyroid function, and vice versa.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Indices of adiposity and thyroid hormones in euthyroid postmenopausal women

Lambrinoudaki

Armeni

Rizos

et al. 2015

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: We aimed to evaluate the association between thyroid hormones and indices of obesity in a sample of euthyroid postmenopausal women. Design: Cross-sectional study. Methods: Serum levels of TSH, free triiodothyronine (FT 3 ), and free thyroxine (FT 4 ) as well as BMI and waist:hip ratio (WHR) were evaluated in 194 healthy euthyroid postmenopausal women. Ultrasonography was used to assess abdominal fat layers (subcutaneous fat (SF), preperitoneal fat (PF), and SF:PF ratio). Indices of adiposity were defined as high vs low depending on the median value of the assessed parameters. Results: After multivariate adjustment for traditional risk factors, lower FT 4 levels and a higher FT 3 :FT 4 ratio predicted higher SF mass (FT 4 , Exp(b)Z0.035, PZ0.020 and FT 3 :FT 4 , Exp(b)Z2.374, PZ0.018), whereas higher FT 3 predicted higher PF mass (Exp(b)Z2.815, PZ0.032). Women with FT 3 :FT 4 above the highest quartile had a significantly higher SF mass as compared to women in the lowest quartile (1.81G0.62 cm vs 1.54G0.46 cm, PZ0.027). BMI had a positive independent association with TSH (Exp(b)Z1.829, PZ0.018). Finally, FT 3 was significantly associated with SF mass among women with higher BMI (FT 3 , bZ0.259, PZ0.040) and women with higher WHR (bZ0.309, PZ0.020) but not among women with lower BMI or WHR values. Conclusion: Thyroid hormone levels, and in particular FT 3 , were independently associated with SF and PF in euthyroid postmenopausal women, and this association was mainly evident in women with higher BMIs. On the other hand, among traditional indices of adiposity, only TSH was positively associated with BMI. Larger prospective studies are needed to evaluate the significance of the present findings.

show abstract

“…T 3 mediates its major effects by binding to nuclear TH receptors (TRs) which regulate the transcription of target genes (3). Abnormalities in TH status are commonly found among endocrine disorders (4) at varying prevalences according to the group of patients that is being studied (5,6).…”

Section: Introductionmentioning

confidence: 99%

Association of antiepileptic drug usage, trace elements and thyroid hormone status

Zevenbergen

Korevaar

Schuette

et al. 2016

European Journal of Endocrinology

View full text Add to dashboard Cite

Background: Levels of thyroid hormone (TH) and trace elements (copper (Cu) and selenium (Se)) are important for development and function of the brain. Anti-epileptic drugs (AEDs) can influence serum TH and trace element levels. As the relationship between AEDs, THs, and trace elements has not yet been studied directly, we explored these interactions. Method: In total 898 participants, from the Thyroid Origin of Psychomotor Retardation study designed to investigate thyroid parameters in subjects with intellectual disability (ID), had data available on serum Se, Cu, thyroid stimulating hormone (TSH), free thyroxine (FT 4 ), tri-iodothyronine (T 3 ), reverse T 3 , T 4 , and thyroxine-binding globulin (TBG); 401 subjects were on AED treatment. Differences in trace elements according to medication usage was investigated using ANOVA, and associations between trace elements and thyroid parameters were analysed using (non-) linear regression models. Results: Study participants were not deficient in any of the trace elements analyzed. AED (carbamazepine, valproate and phenytoin) usage was negatively associated with serum Se and showed compound-specific associations with Cu levels. After correction for drug usage, Se was positively associated with TSH levels, negatively associated with FT 4 levels, and positively with T 3 levels. Cu was positively associated with T 4 , T 3 , and rT 3 , which was largely dependent on TBG levels. Conclusion: The subjects with ID did not display profound deficiencies in trace element levels. AEDs were associated with serum Se and Cu levels, while serum Se and Cu were also associated with thyroid parameters. Further studies on the underlying mechanisms and potential clinical importance are warranted.

show abstract

Thyroid hormones and aging

Cited by 80 publications

References 81 publications

The aging of the endocrine hypothalamus and its dependent endocrine glands

The aging of the endocrine hypothalamus and its dependent endocrine glands

Indices of adiposity and thyroid hormones in euthyroid postmenopausal women

Association of antiepileptic drug usage, trace elements and thyroid hormone status

Contact Info

Product

Resources

About