Thyroid Hormone Stimulation of Adult Brain Fatty Acid Oxidation

Sifuentes, Mikaela; Lechleiter, James D.

doi:10.1016/bs.vh.2017.05.006

Cited by 6 publications

(4 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent research has revealed that thyroxine induces hepatic triglyceride catabolism by activating autophagy, a process that degrades lipid droplets and delivers fatty acids to mitochondria for β-oxidation [13]. Thyroxine has also been found to regulate the gene expression involved in fatty acid metabolism, such as CPT1A and ACOX, which encode enzymes or proteins that facilitate fatty acid transport into mitochondria, the oxidation of fatty acids, and the dissipation of energy as heat [30]. Further, some diiodothyronines, which are products of thyroxine catabolism, have also been shown to have metabolic effects in humans [31], such as modulating mitochondrial function and energy expenditure [32].…”

Section: Discussionmentioning

confidence: 99%

Effects of Thyroid Powder on Tadpole (Lithobates catesbeiana) Metamorphosis and Growth: The Role of Lipid Metabolism and Gut Microbiota

Zhu,

Shao,

et al. 2024

Animals

View full text Add to dashboard Cite

A low metamorphosis rate of amphibian larvae, commonly known as tadpoles, limits the farming production of bullfrogs (Lithobates catesbeiana). This study aimed to examine the effects of processed thyroid powder as a feed additive on tadpole metamorphosis, lipid metabolism, and gut microbiota. Five groups of tadpoles were fed with diets containing 0 g/kg (TH0), 1.5 g/kg (TH1.5), 3 g/kg (TH3), 4.5 g/kg (TH4.5), and 6 g/kg (TH6) thyroid powder for 70 days. The results showed that TH increased the average weight of tadpoles during metamorphosis, with the TH6 group having the highest values. The TH4.5 group had the highest metamorphosis rate (p < 0.05). Biochemical tests and Oil Red O staining showed that the lipid (triglyceride) content in the liver decreased after TH supplementation, especially at doses higher than 1.5 g/kg. RT-qPCR revealed that TH at doses higher than 4.5 g/kg significantly up-regulated the transcriptional expression of the pparα, accb, fas, fadd6, acadl, and lcat genes, which are related to lipid metabolism (p < 0.05). These results showed that TH seems to simultaneously promote the synthesis and decomposition of lipid and fatty acids, but ultimately show a decrease in lipids. As for the gut microbiota, it is noteworthy that Verrucomicrobia increased significantly in the TH4.5 and TH6 groups, and the Akkermansia (classified as Verrucomicrobia) was the corresponding genus, which is related to lipid metabolism. Specifically, the metabolic pathways of the gut microbiota were mainly enriched in metabolic-related functions (such as lipid metabolism), and there were significant differences in metabolic and immune pathways between the TH4.5 and TH0 groups (p < 0.05). In summary, TH may enhance lipid metabolism by modulating the gut microbiota (especially Akkermansia), thereby promoting the growth of tadpoles. Consequently, a supplementation of 4.5 g/kg or 6 g/kg of TH is recommended for promoting the metamorphosis and growth of tadpoles.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Thyroid Powder on Tadpole (Lithobates catesbeiana) Metamorphosis and Growth: The Role of Lipid Metabolism and Gut Microbiota

Zhu,

Shao,

et al. 2024

Animals

View full text Add to dashboard Cite

show abstract

“…However, the response is tissue-specific, and discrepant effects of T 3 and T 4 have been reported. In rat liver, T 3 hyperthyroidism was found to be associated with altered lipid-peroxidation indexes, including elevated levels of TBARS and lipid hydroperoxides that are byproducts of lipid peroxidation [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress and DNA Damage in Peripheral Blood Mononuclear Cells from Normal, Obese, Prediabetic and Diabetic Persons Exposed to Thyroid Hormone In Vitro

Djelić

Borozan

Dimitrijević-Srećković

et al. 2022

IJMS

View full text Add to dashboard Cite

Diabetes, a chronic group of medical disorders characterized byhyperglycemia, has become a global pandemic. Some hormones may influence the course and outcome of diabetes, especially if they potentiate the formation of reactive oxygen species (ROS). There is a close relationship between thyroid disorders and diabetes. The main objective of this investigation was to find out whether peripheral blood mononuclear cells (PBMCs) are more prone to DNA damage by triiodothyronine (T3) (0.1, 1 and 10 μM) at various stages of progression through diabetes (obese, prediabetics, and type 2 diabetes mellitus—T2DM persons). In addition, some biochemical parameters of oxidative stress (catalase-CAT, thiobarbituric acid reactive substances—TBARS) and lactate dehydrogenase (LDH) were evaluated. PBMCs from prediabetic and diabetic patients exhibited increased sensitivity for T3 regarding elevated level of DNA damage, inhibition of catalase, and increase of TBARS and LDH. PBMCs from obese patients reacted in the same manner, except for DNA damage. The results of this study should contribute to a better understanding of the role of thyroid hormones in the progression of T2DM.

show abstract

“…During childhood, they contribute significantly to developing various body systems, particularly the brain (Smith et al, 2002). In adulthood, thyroid hormones are essential for driving metabolic activities and the proper functioning of nearly all organs (Sifuentes & Lechleiter, 2018). Since these hormones are crucial for numerous systems, a continuous supply of thyroid hormones is necessary, and their total serum levels are tightly regulated.…”

Section: Effects Of Curcumin On Thyroid Functionmentioning

confidence: 99%

Multifaceted physiological and therapeutical impact of curcumin on hormone‐related endocrine dysfunctions: A comprehensive review

Wang,

Zhang,

Zhou

2024

Phytotherapy Research

View full text Add to dashboard Cite

Over the past five decades, Curcumin (Cur), derived from turmeric (Curcuma longa), has gained considerable attention for its potential therapeutic applications. Synthesizing insights from clinical trials conducted over the last 25 years, this review delves into diseases where Cur has demonstrated promise, offering a nuanced understanding of its pharmacokinetics, safety, and effectiveness. Focusing on specific examples, the impact of Cur on various human diseases is explored. Endocrine glands and associated signaling pathways are highlighted, elucidating how Cur influences cellular signaling. The article underscores molecular mechanisms such as hormone level alteration, receptor interaction, cytokine and adipokine expression inhibition, antioxidant enzyme activity, and modulation of transcription factors. Cur showcases diverse protective mechanisms against inflammation and oxidative damage by suppressing antiapoptotic genes and impeding tumor promotion. This comprehensive overview emphasizes the potential of Cur as a natural agent for countering aging and degenerative diseases, calling for further dedicated research in this realm.

show abstract

Thyroid Hormone Stimulation of Adult Brain Fatty Acid Oxidation

Cited by 6 publications

References 115 publications

Effects of Thyroid Powder on Tadpole (Lithobates catesbeiana) Metamorphosis and Growth: The Role of Lipid Metabolism and Gut Microbiota

Effects of Thyroid Powder on Tadpole (Lithobates catesbeiana) Metamorphosis and Growth: The Role of Lipid Metabolism and Gut Microbiota

Oxidative Stress and DNA Damage in Peripheral Blood Mononuclear Cells from Normal, Obese, Prediabetic and Diabetic Persons Exposed to Thyroid Hormone In Vitro

Multifaceted physiological and therapeutical impact of curcumin on hormone‐related endocrine dysfunctions: A comprehensive review

Contact Info

Product

Resources

About