Thyroid hormone metabolism in pediatric cardiac patients treated by continuous povidone–iodine irrigation for deep sternal wound infection

Abstract

Our data showed that the use of povidone-iodine irrigation in the patients with DSWI has not lead to any significant alteration in thyroid function within the study period.

Hyperthyrotropinemia at 2 weeks of age indicates thyroid dysfunction and predicts the occurrence of delayed elevation of thyrotropin in very low birth weight infants

“…22,23 Based on these findings, a history of iodine exposure is an important risk factor for the delayed elevation of TSH, but the susceptibility to iodine excess differs from person to person. 24 In our study, some infants showed high urinary iodine excretion. Fuse 25 reported that the computed median value of urinary iodine concentration was 281AE6 lg/l, and extremely high values exceeding 1000 lg/l were found in 16% of schoolchildren.…”

“…In contrast, iodine excess is considered more problematic for the thyroid function of preterm infants because they are susceptible to excessive administration of iodine via radiographic contrast agents and disinfectant agents 22,23 . Based on these findings, a history of iodine exposure is an important risk factor for the delayed elevation of TSH, but the susceptibility to iodine excess differs from person to person 24 . In our study, some infants showed high urinary iodine excretion.…”

The Effect of Antiseptics in the Prophylaxis of Infection in Orthopaedic Surgery

“…Presently, concentrations of topical PVP-I solutions vary substantially according to the operative procedure, ranging up to 10 % in visceral and urologic surgery [17,18]. The topical administration of PVP-I must be used with caution, particularly in patients with previous hypersensitivity reactions against iodine, impaired thyroid or renal function, and following burn injuries [19,20]. For many decades, the natural element iodine has been recognised to possess antiseptic properties with a universal spectrum being effective against gram+ and gram-bacteria, mycobacteria, bacterial spores, fungi, viruses, and protozoa [21,22].…”

Endocrinologic Diseases in Pediatric Cardiac Intensive Care

“…Of these, one developed severe primary hypothyroidism requiring treatment, the second resolved after transient treatment, and the third resolved spontaneously (23). Other studies have shown that the use of povidone-iodine irrigation in association with delayed sternal closure did not lead to any significant alteration in thyroid function (24–26). Further studies are needed to assess the need for monitoring thyroid function after cardiac angiography or prolonged exposure to iodine-containing antiseptics.…”