Thyroid hormone levels predict the change in body weight: a prospective study

Soriguer, Federico; Valdés, Sergio; Morcillo, Sonsoles; Esteva, Isabel; Almaraz, María Cruz; Adana, María Soledad Ruiz de; Tapia, María José; Domínguez, Miguel; Gutiérrez-Repiso, Carolina; Rubio‐Martín, Elehazara; Garrido‐Sánchez, Lourdes; Pérez, Vidal; Garriga, M.; Rojo‐Martínez, Gemma; Garcı́a-Fuentes, Eduardo

doi:10.1111/j.1365-2362.2011.02526.x

Cited by 63 publications

(69 citation statements)

References 39 publications

(68 reference statements)

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“…Ortega et al (33) suggested that fT3 was related with insulin secretion in euthyroid subjects, and T3 levels may be involved in the regulation of insulin secretion. In another study, it was proposed that alterations in thyroid hormones could be the result rather than the source of the increasing weight (34). One of the limitations of the present study is the inclusion of only female participants rather than both sexes.…”

Section: Discussionmentioning

confidence: 66%

Indices of Central and Peripheral Obesity; Anthropometric Measurements and Laboratory Parameters of Metabolic Syndrome and Thyroid Function

Aras¹,

Üstünsoy²,

Armutçu³

2015

Balkan Med J

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Section: Discussionmentioning

confidence: 66%

Indices of Central and Peripheral Obesity; Anthropometric Measurements and Laboratory Parameters of Metabolic Syndrome and Thyroid Function

Aras¹,

Üstünsoy²,

Armutçu³

2015

Balkan Med J

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“…Most population-based studies in healthy (non-LT4 treated) subjects have shown a direct correlation between serum TSH levels within the reference range and body weight, BMI, or fat mass (reviewed by Garin et al) (40), suggesting a role for thyroid-inducible metabolism on body weight and composition. Longitudinal studies have been more divergent, with some but not all studies reporting a correlation between baseline TSH, fT4, or fT3 and weight gain over time (40)(41)(42)(43)(44)(45). However, the correlations have been in different directions, and the point has been raised that weight change may affect thyroid hormone levels, rather than thyroid hormones affecting weight change (46).…”

Section: Lt4 Therapy Energy Expenditure and Body Compositionmentioning

confidence: 99%

Effects of Levothyroxine Replacement or Suppressive Therapy on Energy Expenditure and Body Composition

Samuels

Kolobova

Smeraglio

et al. 2016

Thyroid

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Background: Thyrotropin (TSH)-suppressive doses of levothyroxine (LT4) have adverse effects on bone and cardiac function, but it is unclear whether metabolic function is also affected. The objective of this study was to determine whether women receiving TSH-suppressive LT4 doses have alterations in energy expenditure or body composition. Methods: This study was a cross-sectional comparison between three groups of women: 26 women receiving chronic TSH-suppressive LT4 doses, 80 women receiving chronic replacement LT4 doses, and 16 untreated euthyroid control women. Subjects underwent measurements of resting energy expenditure (REE), substrate oxidation, and thermic effect of food by indirect calorimetry; physical activity energy expenditure by accelerometer; caloric intake by 24-hour diet recall; and body composition by dual X-ray absorptiometry. Results: REE per kilogram lean body mass in the LT4 euthyroid women was 6% lower than that of the LT4-suppressed group, and 4% lower than that of the healthy control group ( p = 0.04). Free triiodothyronine (fT3) levels were directly correlated with REE, and were 10% lower in the LT4 euthyroid women compared with the other two groups ( p = 0.007). The groups of subjects did not differ in other measures of energy expenditure, caloric intake, or body composition. Conclusions: LT4 suppression therapy does not adversely affect energy expenditure or body composition in women. However, LT4 replacement therapy is associated with a lower REE, despite TSH levels within the reference range. This may be due to lower fT3 levels, suggesting relative tissue hypothyroidism may contribute to impaired energy expenditure in LT4 therapy.

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“…Contrary to adults (2,15,18,(31)(32)(33), the role of thyroid hormones in glucose dysmetabolism in otherwise healthy obese children has been examined to a limited extent. In our pediatric population, both BMI-SDS and TSH variations were independently associated with HOMA-IR variation.…”

Section: δBmc-sdsmentioning

confidence: 99%

Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study

Santos

Limbert

Marquês

et al. 2015

Journal of Pediatric Endocrinology and Metabolism

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Background: Serum thyroid stimulating hormone (TSH) levels are frequently elevated in obese children and are most likely to be associated with insulin resistance. However, clinical relevance of this association remains unclear. Objectives: To assess the prevalence of hyperthyrotropinemia; to analyze the relationship between TSH and homeostasis model assessment -insulin resistance (HOMA-IR); and to verify whether TSH levels and HOMA-IR vary with weight loss in obese children. Subjects and Methods: Retrospective longitudinal study with data from baseline and 1 year after lifestyle intervention in a pediatric obese group (344 children were recruited and 100 among them completed follow-up). For postintervention analysis, three groups were considered according to body mass index-standard deviation score (BMI-SDS) variations: ≤ -0.5 (significant weight loss); 0.5-0 (weight loss); and > 0 (weight gain). Statistical analysis was performed using SPSS 19.0

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Thyroid hormone levels predict the change in body weight: a prospective study

Abstract: The changes in the thyroid hormones could be the consequence, rather than the cause, of the increase in weight. The same pathophysiological mechanisms that induce obesity might also be modifying the thyroid hormone pattern.

Cited by 63 publications

References 39 publications

Indices of Central and Peripheral Obesity; Anthropometric Measurements and Laboratory Parameters of Metabolic Syndrome and Thyroid Function

Indices of Central and Peripheral Obesity; Anthropometric Measurements and Laboratory Parameters of Metabolic Syndrome and Thyroid Function

Effects of Levothyroxine Replacement or Suppressive Therapy on Energy Expenditure and Body Composition

Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study

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