Thyroid hormone levels and psychological symptoms in sexually abused adolescent girls

Haviland, Mark G.; Sonne, Janet L.; Anderson, Donald L.; Nelson, Jerald C.; Sheridan-Matney, Clare; Nichols, Joy G.; Carlton, Esther; Murdoch, William G.C.

doi:10.1016/j.chiabu.2005.11.011

Cited by 20 publications

(16 citation statements)

References 41 publications

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“…Goenjian et al (2003) report higher TSH levels for more exposed adolescents, whereas Haviland et al (2006) did not find elevated levels for traumatized girls compared to controls. The latter study reported a negative correlation between PTSD total symptoms and T3.…”

Section: Immune Systemcontrasting

confidence: 62%

Psychophysiological characteristics of PTSD in children and adolescents: A review of the literature

Kirsch

Wilhelm

Goldbeck

2011

Journal of Traumatic Stress

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This review summarizes studies investigating psychophysiological alterations associated with pediatric posttraumatic stress disorder (PTSD). The authors conducted a computer-based search in the databases PsycINFO, PSYNDEXplus, and Medline. Additional studies were retrieved using a pyramid scheme. The literature search identified 29 articles. Most studies measured alterations shortly after exposure. Differences from controls emerged mainly in the sympathoadrenal system and the hypothalamic-pituitary-adrenal axis. Elevated acute heart rate immediately after traumatization was associated with increased risk for PTSD. The literature on psychophysiological characteristics of pediatric PTSD is relatively small and diverse. Nevertheless, findings indicate exaggerated baseline activation across various measures. Studies examining the course and reversibility of psychophysiological alterations are lacking.

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Section: Immune Systemcontrasting

confidence: 62%

Psychophysiological characteristics of PTSD in children and adolescents: A review of the literature

Kirsch

Wilhelm

Goldbeck

2011

Journal of Traumatic Stress

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“…These results may reflect attention dysfunction or effects of allostatic load from chronic trauma. Haviland et al (2006) found that thyroid hormone (free T 3 ) was significantly negatively correlated with PTSD symptoms in recently sexually abused adolescent girls. The authors speculated that physical adaptation to stress may include conservation of this type of hormone or that depression and numbing reactions relate to low T 3 .…”

Section: Persistently Altered Attributions or Expectanciesmentioning

confidence: 97%

Posttraumatic Stress Disorder in Maltreated Youth: A Review of Contemporary Research and Thought

Kearney

Wechsler

Kaur

et al. 2009

Clin Child Fam Psychol Rev

144

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Youths who have been maltreated often experience symptoms of posttraumatic stress disorder (PTSD), and this special population has received increased attention from researchers. Pathways toward maladaptive effects of maltreatment and PTSD are remarkably similar and reflect specific biological diatheses and psychological vulnerabilities that produce wide-ranging self-regulation deficits. Developmental models of effects of maltreatment and of PTSD are thus increasingly intertwined and have begun to inform specialized assessment and treatment strategies for this population. This review covers key aspects of posttraumatic stress disorder in maltreated youth, including epidemiology, symptomatology, outcome, and risk factors as well as assessment and treatment strategies and challenges for these youths.

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“…However, some studies have found the reverse biomedical symptomatology. Haviland et al (2006) report lower levels of T3 among sexually abused adolescent girls, and Sinai et al (2014) observed a lower fT3/fT4 ratio in women with borderline personality disorder (BPD) exposed to interpersonal violence during childhood. The reasons for these observed differences may include comorbid depression, the sex of the individual, as well as type, timing and duration of trauma exposure.…”

Section: Gestational States and Conditions That May Alter Or Intermentioning

confidence: 99%

Influence of maternal thyroid hormones during gestation on fetal brain development

et al. 2017

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Thyroid hormones (TH) play an obligatory role in many fundamental processes underlying brain development and maturation. The developing embryo/fetus is dependent on maternal supply of TH. The fetal thyroid gland does not commence THs synthesis until mid gestation, and the adverse consequences of severe maternal TH deficiency on offspring neurodevelopment are well established. Recent evidence suggests that even more moderate forms of maternal thyroid dysfunction, particularly during early gestation, may have a long-lasting influence on child cognitive development and risk of neurodevelopmental disorders. Moreover, these observed alterations appear to be largely irreversible after birth. It is, therefore, important to gain a better understanding of the role of maternal thyroid dysfunction on offspring neurodevelopment in terms of the nature, magnitude, time-specificity, and context-specificity of its effects. With respect to the issue of context specificity, it is possible that maternal stress and stress-related biological processes during pregnancy may modulate maternal thyroid function. The possibility of an interaction between the thyroid and stress systems in the context of fetal brain development has, however, not been addressed to date. We begin this review with a brief overview of TH biology during pregnancy and a summary of the literature on its effect on the developing brain. Next, we consider and discuss whether and how processes related to maternal stress and stress biology may interact with and modify the effects of maternal thyroid function on offspring brain development. We synthesize several research areas and identify important knowledge gaps that may warrant further study. The scientific and public health relevance of this review relates to achieving a better understanding of the timing, mechanisms and contexts of thyroid programming of brain development, with implications for early identification of risk, primary prevention and intervention.

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Thyroid hormone levels and psychological symptoms in sexually abused adolescent girls

Cited by 20 publications

References 41 publications

Psychophysiological characteristics of PTSD in children and adolescents: A review of the literature

Psychophysiological characteristics of PTSD in children and adolescents: A review of the literature

Posttraumatic Stress Disorder in Maltreated Youth: A Review of Contemporary Research and Thought

Influence of maternal thyroid hormones during gestation on fetal brain development

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