Thyroid Hormone Levels and Its Relationship with Human Chorionic Gonadotropin in Patients with Hydatidiform Mole

Nankali, Anisodowleh; Keshavarzi, Farahnaz; Jalilian, Nasrin; Maryam, Hematti; Elaheh, Basami

doi:10.4236/ojog.2016.61007

Cited by 5 publications

(9 citation statements)

References 29 publications

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“…Estrogens, like progesterone, are known inducers of nausea and vomiting. 7 Its was the case for our patient who has been vomiting two weeks before her admission.…”

Section: Our Patient Presented Most Of This Risk Factorsmentioning

confidence: 71%

Near death 18 weeks preeclampsia in molar pregnancy

Saad¹,

Tanouti²,

Bkiyar³

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Authors present a case of a molar pregnancy of 18 weeks with preeclampsia complicated with acute pulmonary oedema. A condition carrying a significant risk to mother, therefore, raising an important issue on preeclampsia symptoms on pregnancies before 20 weeks. A 31-year-old woman gravida 2, parity 1 presented with dyspnea at 18 weeks' gestation. Blood pressure was very high (180/110 mmHg) and there was markedly proteinuria (+4). She had severe dyspnea and her oxygen saturation level was 75%. Her chest X-ray graph showed massive acute pulmonary oedema. Ultrasonography shows endometrial cavity containing multiple small cystic spaces, creating a characteristic “snowstorm” and “cluster of grapes” appearance. Markedly elevated quantitative human chorionic gonadotropin (250.000 mIU/mL). The acute pulmonary oedema has been managed by diuretics (Furosemide) and oxygen. There was no cardiac abnormalities in the tranthoracic echocardiogram. Authors administered antihypertensive therapy (intravenous nicardipine and lmethyldopa in per os), and magnesium sulfate in prevention of eclamptic seizures. The pregnancy was terminated by uterine evacuation under oxytocin infusion by manual ultrasound aspiration. She was followed up intensive care unit for two days. Causes of secondary high blood pressure had been eliminated. The patient's blood pressure rapidly normalized two days after delivery. Dyspnea disappeared one day later. Pathologic and cytogenetic analyses revealed a complete hydatiform mole. Two days after delivery; the serum β-hCG level was 99000 mlU/ml. A control ultrasonography shows an empty uterus. Hydatidiform mole is classified into 2 different subtypes, complete hydatidiform mole and partial or incomplete hydatidiform mole development of preeclampsia prior to 20 weeks of gestation should prompt a clinical evaluation to exclude the possibility of an underlying hydatidiform molar pregnancy. Ultrasonography and level of serum BHCG are the initial investigation of choice for the detection of hydatidiform mole. Aspiration is the treatment of reference.

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“…Estrogens, like progesterone, are known inducers of nausea and vomiting. 7 Its was the case for our patient who has been vomiting two weeks before her admission.…”

Section: Our Patient Presented Most Of This Risk Factorsmentioning

confidence: 71%

Near death 18 weeks preeclampsia in molar pregnancy

Saad¹,

Tanouti²,

Bkiyar³

et al. 2020

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…It is due to hypersecretion of β-hCG. Indeed, hCG stimulates the corpus luteum to the production of estradiol and progesterone via their receptors luteinizing hormone-chorionic gonadotrophin receptor (LH-CGR) and plays a promotive role in the aromatization of steroids of the placenta [12]. Estrogens, like progesterone, are known inducers of nausea and vomiting.…”

Section: Discussionmentioning

confidence: 99%

“…These secretions could in turn stimulate the mechanoreceptors present throughout the digestive tract, and trigger reflex vomiting by distension and activation of the gastrointestinal tract [13]. Finally, hCG is believed to be responsible for biological hyperthyroidism through thyrotropic action linked to a structural homology between hCG molecules and Thyroid Stimulating Hormon (TSH), as well as for their respective receptors explaining the action of hCG on TSH receptors [12] [14]. The patient can also complain of pelvic pain, present in 20% of cases and related to the presence of luteal cysts or the expulsion of vesicles [4].…”

Section: Discussionmentioning

confidence: 99%

Complete Hydatiform Mole Revealed by a Severe Preeclampsia on Added in a 39-Year-Old Pregnant: Report of a Case Followed in Kisangani (DRC) and Review of the Literature

Nguma¹,

Labama²,

Nadi³

et al. 2018

OJOG

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The classic picture of a hydatiform mole is made of recurrent metrorrhagia, exaggeration of sympathetic signs, increase of uterine volume compared to gestational age and marked elevation of serum β-hCG. The occurrence of preeclampsia is less common and its mechanism is less well known. In this case, the authors report an atypical presentation of the complete hydatiform mole alarmed by chronic hypertension with preeclampsia added to a pregnant woman of 39 years. The management involved stopping the pregnancy and normalization of the blood pressure figures was spectacular after uterine aspiration.

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“…http://ddj.hums.ac.ir http Clinical hyperthyroidism is relatively prevalent and occurs in 1 per 100 pregnancies. This condition can be justified by the similarity of the β-HCG subunit to TSH (4). The relationship between increased β-HCG and TSH level during pregnancy has been known for years (4).…”

Section: The Association Of Thyroid Hormones With β-Hcg In Patients Wmentioning

confidence: 99%

“…Histologically, the hydatidiform mole is characterized by a disorder in the chorionic villi, including trophoblastic proliferation and villous stromal edema (2). Hydatidiform mole is the most prevalent form of GTD (3,4) occurring in 1 per 1000 pregnancies in the world (5,6). The prevalence of hydatidiform mole differs in different regions.…”

Section: Introductionmentioning

confidence: 99%

The Association of Thyroid Hormones With β-HCG in Patients With Hydatidiform Mole

et al. 2020

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Background: A hydatidiform mole or molar pregnancy is the most prevalent gestational trophoblastic disease (GTD). About 55%-60% of women with trophoblastic diseases have overt hyperthyroidism at the time of diagnosis, which may have severe manifestations. This study examined the relationship between gestational hypertension and the level of thyroid hormones with beta human chorionic gonadotropin (β-HCG) in patients with a hydatidiform mole. Materials and Methods: This cross-sectional study enrolled 65 patients with a hydatidiform mole admitted to Khalij-e Fars hospital, Bandar Abbas, Iran. Patients were divided into three groups of clinical hyperthyroidism, subclinical hyperthyroidism, and healthy. The serum levels of thyroid-stimulating hormone (TSH), T4, T3, and β-HCG were checked in all subjects, and the relationship between gestational hypertension and the level of thyroid hormones with β-HCG in patients with a hydatidiform mole was examined. Results: The mean age of patients was 29.93 ± 9.04 years, and their mean gestational age was 11.09 ± 4.2 weeks. In this study, 12.3% of the patients had subclinical hyperthyroidism, 41.5% had clinical hyperthyroidism, and 46.2% were healthy. A significant relationship was found between the serum level of β-HCG and thyroid function in patients with clinical and subclinical hyperthyroidism compared to the healthy group (P= 0.001). No significant relationship was found between systolic/ diastolic blood pressure and the serum level of β-HCG. Conclusion: A significant relationship was observed between the serum levels of β-HCG and TSH, free T3, and free T4 in patients with a hydatidiform mole and thyrotoxicosis. Thus, early diagnosis of hyperthyroidism can help treat these patients more quickly.

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Thyroid Hormone Levels and Its Relationship with Human Chorionic Gonadotropin in Patients with Hydatidiform Mole

Cited by 5 publications

References 29 publications

Near death 18 weeks preeclampsia in molar pregnancy

Near death 18 weeks preeclampsia in molar pregnancy

Complete Hydatiform Mole Revealed by a Severe Preeclampsia on Added in a 39-Year-Old Pregnant: Report of a Case Followed in Kisangani (DRC) and Review of the Literature

The Association of Thyroid Hormones With β-HCG in Patients With Hydatidiform Mole

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