2009
DOI: 10.1159/000203644
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Thyroid Hormone Level Positively Regulates NOS and cGMP in the Developing Rat Cerebellum

Abstract: Thyroid hormones and nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling play a significant role in the structural development of the cerebellum, respectively. In the present study, the possible contribution of neuronal NO synthase (NOS) and cGMP in the thyroid hormone-induced structural changes was investigated in the cerebella of postnatal rats at different hormone levels. Animals were treated from postnatal day 4 until days 7, 14, and 21, by i.p. injection of 1 μg thyroxine (T4)/10 g … Show more

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Cited by 7 publications
(1 citation statement)
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“…This was the fi rst report of TRH action outside the pituitary gland. On the other hand, NOS and cGMP contribute to cerebellar development induced by thyroid hormone (Serfozo et al 2009 ). These reports suggest that TRH might play a role in developing the cerebellum by inducing cGMP independently of thyroid hormone.…”
Section: Potential Roles Of Trh In the Brainmentioning
confidence: 99%
“…This was the fi rst report of TRH action outside the pituitary gland. On the other hand, NOS and cGMP contribute to cerebellar development induced by thyroid hormone (Serfozo et al 2009 ). These reports suggest that TRH might play a role in developing the cerebellum by inducing cGMP independently of thyroid hormone.…”
Section: Potential Roles Of Trh In the Brainmentioning
confidence: 99%