Thyroid hormone‐induced swim bladder and eye maturation are transduced by IGF‐1 in zebrafish embryos

Molla, Mohammad Habibur Rahman; Hasan, Tawheed; Jang, Won Je; Diaz, Cesar D. Soria; Appenteng, Patrick; Marufchoni, Haliliy; Jahan, Bushra; Brown, Christopher L.

doi:10.1111/are.14305

Cited by 16 publications

(19 citation statements)

References 37 publications

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“…Since THs are crucial regulators of growth ( 148 , 149 ), inhibition of thyroid function results in impairment in the development of brain, skeleton, and other organs, as well as in pigmentation. For example, in zebrafish, treatment with T 3 increases IGF-1 expression and enhances swim bladder and eye development but IGF-1 receptor blockade suppresses these effects of T 3 on swim bladder and eye ( 150 ).…”

Section: Role Of the Thyroid Axis On Somatic Development And Growthmentioning

confidence: 99%

The Role of the Thyroid Axis in Fish

2020

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In all vertebrates, the thyroid axis is an endocrine feedback system that affects growth, differentiation, and reproduction, by sensing and translating central and peripheral signals to maintain homeostasis and a proper thyroidal set-point. Fish, the most diverse group of vertebrates, rely on this system for somatic growth, metamorphosis, reproductive events, and the ability to tolerate changing environments. The vast majority of the research on the thyroid axis pertains to mammals, in particular rodents, and although some progress has been made to understand the role of this endocrine axis in non-mammalian vertebrates, including amphibians and teleost fish, major gaps in our knowledge remain regarding other groups, such as elasmobranchs and cyclostomes. In this review, we discuss the roles of the thyroid axis in fish and its contributions to growth and development, metamorphosis, reproduction, osmoregulation, as well as feeding and nutrient metabolism. We also discuss how thyroid hormones have been/can be used in aquaculture, and potential threats to the thyroid system in this regard.

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Section: Role Of the Thyroid Axis On Somatic Development And Growthmentioning

confidence: 99%

The Role of the Thyroid Axis in Fish

2020

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“…Experimental applications of Insulin-like Growth Factor-1 (IGF-1) receptor blockers and analysis of IGF-1 gene expression revealed that eye differentiation in response to maternal TH signaling is transduced by IGF-1. Treatment with exogenous TH causes expression of IGF-1 genes, thereby accelerating initial eye function by up to three or four days [45]. A parallel assortment of somatosensory deficiencies is reported in response to mammalian neonatal hypothyroidism [46].…”

Section: Functional Sensory Systemsmentioning

confidence: 98%

“…Perception of food items depends in part on eye and lateral line function, and olfactory organ input; pursuit of prey involves efficient swimming and neutral buoyancy, and the processing of food, absorption and utilization of nutrients hinge on the effective production of digestive enzymes. The maturation of the aforementioned physiological systems is strongly regulated by thyroid hormones of maternal origin, and all of these mechanisms become active on or slightly before the time of first-feeding [44,45]. Early maturational events in the central nervous system are also dependent on maternally-derived thyroid hormones, enabling the processing of and responsiveness to critically important information.…”

Section: Maternal Thyroid Signaling In Larval Fishesmentioning

confidence: 99%

“…The eyes also differentiate and become functional in response to maternal thyroid signaling, just before the onset of feeding in zebrafish [45]. Experimental applications of Insulin-like Growth Factor-1 (IGF-1) receptor blockers and analysis of IGF-1 gene expression revealed that eye differentiation in response to maternal TH signaling is transduced by IGF-1.…”

Section: Functional Sensory Systemsmentioning

confidence: 99%

“…Larval fishes with undifferentiated or uninflated swim bladders are unable to swim efficiently and they can readily become a component of the heavy mortalities associated with failed transitions to first feeding. Swim bladder ontogeny and inflation are under the control of maternal thyroid hormones [42,43], and TH-induced swimbladder maturation and initial function are transduced by IGF-1, as is eye development [45]. A significant improvement in swimbladder inflation rate is attributed to TH exposure [42] and a strong relationship (p < 0.005) was reported between egg T 3 content and survival to two weeks post-hatching in striped bass (Morone saxatilis), with a correlation coefficient of 0.922 [42].…”

Section: Locomotor System Maturationmentioning

confidence: 99%

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Evolution of Thyroid Enhancement of Embryogenesis and Early Survival

Pataueg¹,

Larson²,

Brown³

2022

Hypothyroidism - New Aspects of an Old Disease

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Iodine imparts protective antioxidant actions that improve the fitness of invertebrate organisms, and peptides carrying iodine initially appear to have served in a defensive capacity. Tyrosine carries multiple iodines in some echinoderms, and these peptides transferred to progeny serve both protective and signaling purposes. This parental relationship appears to be the most likely evolutionary basis for emergence of the vertebrate thyroid endocrine system, and its critically important development-promoting actions in larval and (later) fetal ontogeny. Thyroxine (T4) and Triiodothyronine (T3) induce settlement and stimulate transitions to alternative feeding modes in some echinoderms. This transgenerational relationship has been conserved and elaborated in vertebrates, including humans, which share common ancestry with echinoderms. Thyroid insufficiency is damaging or can be lethal to larval fishes; egg yolk that is insufficiently primed with maternal thyroid hormones (TH) results in compromised development and high mortality rates at the time of first-feeding. Maternally-derived TH supplied to offspring supports the onset of independent feeding in fishes (eye, mouth, lateral line, swim bladder and intestinal maturation) and survival by comparable developmental mechanisms in placental mammals. Fishes evolved precise control of TH secretion and peripheral processing; early metamorphic and feeding mode actions were joined by controlled thermogenesis in homeotherms.

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Probiotic Treatment Enhances Pre‐feeding Larval Development and Early Survival in Zebrafish Danio rerio

et al. 2022

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The growth and development of healthy culture subjects are essential in increasing productivity in the aquaculture industry. A primary determinant of aquatic animal productivity is the ambient microbial population. If an aquatic animal's microbiome is diverse, with bacteria favoring beneficial over pathogenic species, the health and growth of the animal (i.e., fish or crustacean) can be substantially improved. Embryonic and newly hatched Zebrafish Danio rerio larvae were reared in the presence of (1) water from the broodstock culture tank as a control, (2) a probiotic solution containing 19 strains of live lactic acid bacteria (LAB), or (3) an antibiotic (AB) solution with amoxycillin. Developmental parameters were monitored until 10 d postfertilization. Bacteria present in the water and larvae were cultured and identified by sequencing the V4 hypervariable region of bacterial 16S ribosomal RNA. Probiotic‐treated larvae showed significant increases in every measured morphological parameter and in survival compared to the controls and AB‐treated larvae, including TL, eye development, and swim bladder development before first feeding. Staining with DASPEI (2‐(4‐[dimethylamino]styryl)‐N‐ethylpyridinium iodide) produced fluorescence, revealing increased mitochondrial activity in the gastrointestinal tracts of probiotic‐treated larvae and reflecting advancement of initial metabolic function. Probiotic‐treated larvae showed accelerated yolk absorption, resulting in increased nutrient mobilization and growth. Microbial analyses revealed a greater concentration of bacteria in larvae in response to the probiotic treatment compared to the other two treatments. Species identified in all three treatments included Pseudomonas spp. and Aeromonas spp. (Proteobacteria). The second most diverse and abundant microbiome was seen in controls, whereas AB‐treated larvae had the least diverse microbiome. All treatments revealed the presence of proteobacteria, but an AB‐resistant pathogenic bacterium (Stenotrophomonas maltophilia) was identified in the AB group. These results reveal that the presence of LAB and other bacteria favorably influenced early larval growth, development, digestive function, and survival in Zebrafish even before the onset of feeding.

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Thyroid hormone‐induced swim bladder and eye maturation are transduced by IGF‐1 in zebrafish embryos

Cited by 16 publications

References 37 publications

The Role of the Thyroid Axis in Fish

The Role of the Thyroid Axis in Fish

Evolution of Thyroid Enhancement of Embryogenesis and Early Survival

Probiotic Treatment Enhances Pre‐feeding Larval Development and Early Survival in Zebrafish Danio rerio

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