Thyroid Hormone Enhances Neurite Outgrowth in Neuroscreen 1 Cells

Ce, Oldham; Cj, Wooten; Ab, Williams; Dixon, Scott J.; Lopez, Dayami

doi:10.31531/2581-4745.1000104

Cited by 2 publications

(1 citation statement)

References 63 publications

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“…The hippocampus displays a high concentration of receptors for TH and dysregulation of TH results in significant impairment of both cognitive and memory functions ( 65 ). Thyroid hormone enhances the action of nerve growth factor and promotes the growth of neurites ( 66 ). Thyroid hormones can also affect adult hippocampal neurogenesis by stimulating the proliferation, survival and differentiation of dentate granule cell progenitors ( 67 ).…”

Section: Thyroid Dysfunction As the Cause Of Admentioning

confidence: 99%

Thyroid dysfunction and Alzheimer's disease, a vicious circle

Li,

Liu

2024

Front. Endocrinol.

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Recently, research into the link between thyroid dysfunction and Alzheimer’s disease (AD) remains a current topic of interest. Previous research has primarily concentrated on examining the impact of thyroid dysfunction on the risk of developing AD, or solely explored the mechanisms of interaction between hypothyroidism and AD, a comprehensive analysis of the mechanisms linking thyroid dysfunction, including hyperthyroidism and hypothyroidism, to Alzheimer’s disease (AD) still require further elucidation. Therefore, the aim of this review is to offer a thorough and comprehensive explanation of the potential mechanisms underlying the causal relationship between thyroid dysfunction and AD, highlighting the existence of a vicious circle. The effect of thyroid dysfunction on AD includes neuron death, impaired synaptic plasticity and memory, misfolded protein deposition, oxidative stress, and diffuse and global neurochemical disturbances. Conversely, AD can also contribute to thyroid dysfunction by affecting the stress repair response and disrupting pathways involved in thyroid hormone (TH) production, transport, and activation. Furthermore, this review briefly discusses the role and significance of utilizing the thyroid as a therapeutic target for cognitive recovery in AD. By exploring potential mechanisms and therapeutic avenues, this research contributes to our understanding and management of this devastating neurodegenerative disease.

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Section: Thyroid Dysfunction As the Cause Of Admentioning

confidence: 99%

Thyroid dysfunction and Alzheimer's disease, a vicious circle

Li,

Liu

2024

Front. Endocrinol.

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Is Hyperthyroidism a Possible Etiology of Early Onset Dementia?

Mathew

Jose

Elshaikh

et al. 2020

Cureus

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Dementia, a disabling syndrome of the elderly characterized by the decline in memory and cognition, is increasing in incidence and affects not only the individual but also their family and close ones. Hyperthyroidism can mimic many other diseases and untreated hyperthyroidism can lead to adverse problems of various systems including the heart, bones, muscles, menstrual cycle, and fertility. In this article, we have tried to evaluate the association between hyperthyroidism and dementia, as well as the impact of hyperthyroidism management in the treatment and prevention of dementia. Studies available in the PubMed database have been used, excluding animal studies and including studies of adults above the age of 50. The analysis of studies reveals that thyroid dysfunction can lead to cognitive impairment. It has not been able to prove that hyperthyroidism can lead to an earlier onset of dementia. But subclinical hyperthyroidism, thyroid-stimulating hormone (TSH) levels below the normal range, and high free thyroxine (T4) levels increase the risk of dementia among the elderly. The possible mechanisms involved in this association have also been discussed. Thus, we concluded that it is essential to detect and manage hyperthyroidism at an earlier stage since hyperthyroidism increases the risk of dementia. The possibility of using antithyroid treatment in euthyroid dementia is yet to be studied extensively.

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Thyroid Hormone Enhances Neurite Outgrowth in Neuroscreen 1 Cells

Cited by 2 publications

References 63 publications

Thyroid dysfunction and Alzheimer's disease, a vicious circle

Thyroid dysfunction and Alzheimer's disease, a vicious circle

Is Hyperthyroidism a Possible Etiology of Early Onset Dementia?

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