Thyroid Hormone-Disrupting Potentials of Major Benzophenones in Two Cell Lines (GH3 and FRTL-5) and Embryo-Larval Zebrafish

Lee, Jungeun; Kim, Sujin; Park, Young Joo; Moon, Hyo Bang; Choi, Kyungho

doi:10.1021/acs.est.8b01796

Cited by 67 publications

(43 citation statements)

References 57 publications

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“…The results of correlation analysis also support the essential roles of the transcription of the trh, tshβ, and tshr genes in thyroid hormone regulation. The upregulation of tshβ and tshr genes by exposure to avobenzone and octinoxate observed in this study is similar to that of previous studies that reported elevation of TSH-related genes by BPs and octinoxate (Chu et al 2021;Lee et al 2018).…”

Section: Discussionsupporting

confidence: 91%

“…Therefore, downregulation of the trαa and trβ genes in sh larvae exposed to avobenzone and octinoxate may also suggest possible activities to inhibit thyroid hormone receptor binding. The observation of higher mortality in thrαa −/− than in wild-type sh is interesting, given that BPs and octinoxate have been reported to inhibit receptor binding capacity in previous studies (Chu et al 2021;Lee et al 2018). Our observation also supports the central role of the thyroid hormone receptor in the toxicity of avobenzone and octinoxate.…”

Section: Discussionsupporting

confidence: 86%

“…Avobenzone belongs to the BP group along with deoxybenzone, sulisobenzone (also known as BP-4), and oxybenzone (also known as BP-3) (Kullavanijaya and Lim 2005). The changes in the levels of thyroid hormones, such as the decrease in T4 level, are consistent with the effects of other BPs, including BP-1, BP-3, and BP-8 (Lee et al 2018).…”

Section: Discussionsupporting

confidence: 76%

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Waterborne Exposure to Avobenzone and Octinoxate Induces Thyroid Endocrine Disruption in Wild-Type and Thrαa-/- Zebrafish Larvae

2022

Preprint

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Avobenzone and octinoxate are frequently used as organic ultraviolet filters, and these chemicals are widely detected in water. This study evaluated the potential of avobenzone and octinoxate to disrupt thyroid endocrine system in wild-type and thyroid hormone receptor alpha a knockout (thrαa−/−) zebrafish embryos/larvae. Following a 120 h exposure to various concentrations of avobenzone and octinoxate, larvae mortality and developmental toxicity in wild-type and thrαa−/− fish were assessed. Triiodothyronine (T3) and thyroxine (T4) levels as well as transcriptional levels of ten genes associated with the hypothalamus-pituitary-thyroid (HPT) axis were measured in wild-type fish. Significantly lower larvae survival rate in thrαa−/− fish exposed to ≥ 3 µM avobenzone and octinoxate suggests that the thyroid hormone receptor plays a crucial role in the toxic effects of avobenzone and octinoxate. A significant increase in the deio2 gene level in avobenzone-exposed zebrafish supports the result of an increased ratio of T3 to T4. Significant decrease of T4 level with upregulation of trh, tshβ, and tshr genes indicates feedback in the hypothalamus and pituitary gland to maintain hormonal homeostasis. Our observation indicates that exposure to avobenzone and octinoxate affects the feedback mechanisms of the HPT axis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 86%

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Waterborne Exposure to Avobenzone and Octinoxate Induces Thyroid Endocrine Disruption in Wild-Type and Thrαa-/- Zebrafish Larvae

2022

Preprint

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“…Triiodothyronine (T3) was found to be positively associated with risk factors for GDM [39]. An animal study indicated that BP-3 could down-regulate genes related to thyroid stimulating hormones with significant decreases in T3 levels [40], and similar associations were found among pregnant women [41]. Therefore, it is possible that exposure to BP-3 could lead to decreased level of T3 and decreased GDM risk, potentially via decreasing endogenous glucose production and plasma glucose [42].…”

Section: Discussionmentioning

confidence: 96%

Perinatal urinary benzophenone-3 concentrations and glucose levels among women from a fertility clinic

et al. 2020

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Background: Subfertile women have higher risk of glucose intolerance during pregnancy. Studies suggest associations between several endocrine disrupting chemicals (EDCs) and pregnancy glucose levels. However, the association between benzophenone-3 (BP-3), an EDC widely found in sunscreen, and pregnancy glucose levels remains unclear. We aimed to assess the association between perinatal exposures to BP-3 and pregnancy glucose levels in subfertile women. Methods: We evaluated 217 women from a prospective cohort based at a fertility clinic who had urinary BP-3 concentrations measured during 3-month preconception, first and/or second trimesters, and blood glucose measured at glucose load tests (GLTs) during late pregnancy. Multivariable linear and logistic regression models were used to assess associations between time-specific BP-3 in quartiles (Q1-Q4) and mean glucose levels, as well as odds of abnormal GLT (glucose level ≥ 140 mg/dL), adjusting for potential confounders. Effect modification was assessed by age, season, BMI, infertility diagnosis, sex of fetus (es) and physical activity. Results: Women with higher first trimester BP-3 concentrations had lower mean glucose levels [mean glucose (95% CI) for Q4 vs Q1 = 103.4 (95.0, 112.5) vs. 114.6 (105.8, 124.2) mg/dL]. Women with higher second trimester BP-3 concentrations had lower odds of abnormal GLT [OR (95% CI) for Q3 vs. Q1 = 0.12 (0.01, 0.94)]. The associations between BP-3 and glucose levels were modified by several factors: women with female-factor infertility, urine collected during summer, older age, lower BMI, or carried female fetus (es) had the strongest inverse associations between BP-3 and glucose levels, while no associations were observed in the remaining subgroups. Conclusions: Time-specific inverse associations between BP-3 and pregnancy glucose levels existed in subfertile women, and especially among certain subgroups of this high-risk-population.

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“…All but one displayed estrogenic activity [174]. As regards the thyroid axis, in vitro studies showed five benzophenones to significantly to decrease expression of thyroid-responsive genes [175]. The same study showed benzophenone-1, benzophenone-3 and benzophenone-8 to decrease thyroid hormone levels in an animal model.…”

Section: Benzophenonesmentioning

confidence: 87%

Mikroplastik: vom Tiegel auf den Teller

Saha¹

2021

Dtsch Dermatolog

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This study, commissioned by the PETI Committee of the European Parliament, presents the scientific knowledge regarding the health effects of endocrine disruptors, a class of hazards recognized in EU regulation since 1999. This report reviews the scientific evidence regarding the concept of endocrine disruption, the extent of exposure, associated health effects and costs. The existing relevant EU regulations are discussed and recommendations made to better protect human health. ABOUT THE PUBLICATIONThis research paper was requested by the European Parliament's Committee on Petitions and commissioned, overseen and published by the Policy Department for Citizen's Rights and Constitutional Affairs.Policy Departments provide independent expertise, both in-house and externally, to support European Parliament committees and other parliamentary bodies in shaping legislation and exercising democratic scrutiny over EU external and internal policies.

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Thyroid Hormone-Disrupting Potentials of Major Benzophenones in Two Cell Lines (GH3 and FRTL-5) and Embryo-Larval Zebrafish

Cited by 67 publications

References 57 publications

Waterborne Exposure to Avobenzone and Octinoxate Induces Thyroid Endocrine Disruption in Wild-Type and Thrαa-/- Zebrafish Larvae

Waterborne Exposure to Avobenzone and Octinoxate Induces Thyroid Endocrine Disruption in Wild-Type and Thrαa-/- Zebrafish Larvae

Perinatal urinary benzophenone-3 concentrations and glucose levels among women from a fertility clinic

Mikroplastik: vom Tiegel auf den Teller

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