Thyroid Hormone Changes After Sleeve Gastrectomy With and Without Antral Preservation

Karaman, Kerem; Mansıroglu, Kaan; Subaşı, Özkan; Biricik, Aytaç; Yırgın, Hakan; Köse, Elif; Ercan, Metin

doi:10.1007/s11695-020-04896-4

Cited by 4 publications

(3 citation statements)

References 52 publications

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“…Although only 2 SNVs were screened as the IVs and the validity of the results is not as stable as the relation shown by MR between BMI and TSH, such a causal association has also been confirmed by several previous studies. It has been demonstrated that in obese patients undergoing metabolic surgery or lifestyle intervention, serum fT3 could be significantly reduced along with TSH during follow-up, while the fT4 level showed nonsignificant variation ( 44 , 45 ). Moreover, several cross-sectional studies also found similar associations ( 46-48 ).…”

Section: Discussionmentioning

confidence: 99%

Causal Association Between Serum Thyrotropin and Obesity: A Bidirectional, Mendelian Randomization Study

Wang

Gao

Han

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context The association between serum thyroid-stimulating hormone (TSH) and obesity traits has been investigated previously in several epidemiological studies. However, the underlying causal association has not been established. Objective To determine and analyze the causal association between serum TSH level and obesity-related traits (BMI and obesity). Design, Setting, Participants The latest genome-wide association studies (GWASs) on TSH, BMI and obesity were searched to obtain full statistics. Bidirectional two-sample Mendelian randomization (MR) was performed to explore the causal relationship between serum TSH and BMI and obesity. The inverse variance-weighted (IVW) and MR-Egger methods were used to combine the estimation for each SNP. Based on the preliminary MR results, free thyroxine (fT4) and free triiodothyronine (fT3) levels were also set as outcomes to further analyze the impact of BMI on them. Main Outcome Measures BMI and obesity were treated as the outcomes to evaluate the effect of serum TSH on them, and TSH was set as the outcome to estimate the effect of BMI and obesity on it. Results Both IVW and MR-Egger results indicated that genetically driven serum TSH did not causally lead to changes in BMI or obesity. Moreover, the IVW method showed that the TSH level could be significantly elevated by genetically predicted high BMI (β=0.038, se=0.013, p=0.004). In further MR analysis, the IVW method indicated that BMI could causally increase the fT3 (β=10.123, se=2.523, p<0.001) while not significantly affecting the fT4 level. Conclusion Together with fT3, TSH can be significantly elevated by an increase in genetically driven BMI.

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Section: Discussionmentioning

confidence: 99%

Causal Association Between Serum Thyrotropin and Obesity: A Bidirectional, Mendelian Randomization Study

Wang

Gao

Han

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…We analyzed the data of 256 Chinese patients and revealed a significant decrease in TSH and other thyroid 16) investigated the variations in thyroid function following RYGB and discovered that TSH remained steady. FT3 and FT4 have also been reported to be elevated, unchanged, or decreased after bariatric surgery in previous studies, with the varying results primarily attributable to differences in ethnic groups, surgical procedures, and sample sizes (9,14,19,36,37). However, the present study included, to the best of our knowledge, the largest number of Chinese euthyroid patients with obesity and comprehensively analyzed the two most common bariatric surgical procedures (SG and RYGB), so it may be able to provide more reliable data for Chinese patients.…”

Section: Discussionmentioning

confidence: 94%

Total weight loss induces the alteration in thyroid function after bariatric surgery

Tian,

Nie,

et al. 2024

Front. Endocrinol.

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BackgroundBariatric surgery is an effective approach to weight loss, which may also affect thyroid function. However, alteration in thyroid-stimulating hormone (ΔTSH) and thyroid hormones after bariatric surgery and the relationship between thyroid function and postoperative weight loss still remains controversial.MethodsData were collected from euthyroid patients with obesity who underwent sleeve gastrectomy and Roux-en-Y gastric bypass from 2017 to 2022. The alterations of free thyroxine (FT4), free triiodothyronine (FT3), total thyroxine (TT4), total triiodothyronine (TT3), and TSH were calculated 1 year after surgery. Pearson correlation analysis was used to assess the correlation between the percentage of total weight loss (%TWL) and ΔTSH. Multivariable linear regression was utilized to determine the association between %TWL and ΔTSH.ResultsA total of 256 patients were included in our study. The mean %TWL was 28.29% after 1 year. TSH decreased from 2.33 (1.67, 3.04) uIU/mL to 1.82 (1.21, 2.50) uIU/mL (P < 0.001), FT3 decreased from 3.23 ± 0.42 pg/mL to 2.89 ± 0.41 pg/mL (P < 0.001), FT4 decreased from 1.11 ± 0.25 ng/dL to 1.02 ± 0.25 ng/dL (P < 0.001), TT3 decreased from 1.13 (1.00, 1.25) ng/mL to 0.89 (0.78, 1.00) ng/mL (P < 0.001), and TT4 decreased from 8.28 ± 1.69 ug/mL to 7.82 ± 1.68 ug/mL 1 year postoperatively (P < 0.001). %TWL was found to be significantly correlated to ΔTSH by Pearson correlation analysis (Pearson correlation coefficient = 0.184, P = 0.003), indicating that the more weight loss, the more TSH declined. After adjusting for covariates in multivariable linear regression, %TWL was found to be independently associated with ΔTSH (β = 0.180 [95% confidence interval (CI), 0.048 – 0.312], P = 0.008). Moreover, %TWL was divided into 3 categorical groups (%TWL ≤ 25%, 25% < %TWL ≤ 35%, and %TWL > 35%) for further exploration, and was also found to be an independent predictor for ΔTSH after adjusting for covariates in multivariable linear regression (β = 0.153 [95% CI, 0.019 – 0.287], P = 0.025).ConclusionTSH, FT4, FT3, TT4, and TT3 decrease significantly 1 year after bariatric surgery. The decline in TSH is independently mediated by postoperative weight loss; the more the weight loss, the more the TSH decrease.

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“…It is an endocrine disorder caused by insufficient synthesis secretion/biological effect or excessive release of thyroid hormones due to low or high thyroid action ( 2 ). Abnormal functional status increases the risk of anxiety, anger, obesity, diabetes, hypertension, and thyroid cancer among doctors and nurses ( 3 ), which adversely affects patient care, such as inappropriate protective measures leading to exposure to low-dose radiation, emotional instability of doctors and nurses leading to tension between doctors and patients, and long-term suboptimal health of doctors and nurses affecting the treatment plan ( 4 , 5 ). Therefore, it is important to explore the abnormal thyroid function of medical staff in radiotherapy departments and its associated factors to promote harmony between doctors and patients and maintain the physical and mental health of medical and nursing staff.…”

Section: Introductionmentioning

confidence: 99%

Analysis of factors associated with abnormal thyroid function among medical staff in radiotherapy departments

Ren,

Bai

et al. 2023

Front. Public Health

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ObjectiveTo understand abnormal thyroid function and its associated factors among medical staff in radiotherapy departments.MethodsData related to medical staff in radiotherapy departments who met the inclusion and exclusion criteria were analyzed from September to December 2022 in Shenyang, Liaoning Province, including basic personal and lifestyle habits, work information, and scores on the Depression Self-Assessment Scale, Perception Stress Scale, and the Generalized Anxiety Scale. Data analysis was performed using the χ2 test and binary logistic regression.ResultsAmong 484 medical staff in the radiotherapy department, 147 (30.4%) had abnormal thyroid function. Binary logistic regression analysis showed that age, years of work, smoking, occupational exposure, smoking, late-night snacking habits, depression, and stress perception were factors associated with abnormal thyroid function among medical staff in radiotherapy departments; on the other hand, physical exercise was a protective factor.ConclusionThe positive rate of thyroid dysfunction among medical personnel in the radiology department is relatively high. It is necessary to strengthen health education and awareness among relevant practitioners and improve the coverage of occupational disease prevention and control education.

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Thyroid Hormone Changes After Sleeve Gastrectomy With and Without Antral Preservation

Cited by 4 publications

References 52 publications

Causal Association Between Serum Thyrotropin and Obesity: A Bidirectional, Mendelian Randomization Study

Causal Association Between Serum Thyrotropin and Obesity: A Bidirectional, Mendelian Randomization Study

Total weight loss induces the alteration in thyroid function after bariatric surgery

Analysis of factors associated with abnormal thyroid function among medical staff in radiotherapy departments

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