Thyroid hormone and obesity

Pearce, Elizabeth N.

doi:10.1097/med.0b013e328355cd6c

Cited by 148 publications

(121 citation statements)

References 47 publications

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“…Interdependency between serum leptin and TH concentrations is assumed to be mediated by a complex interplay with TSH, further involving thyrotropin-releasing hormone (46,47). In concordance, a recent study on young men provided evidence for a link between serum TSH and leptin concentrations, even in the euthyroid state (48).…”

Section: Figsupporting

confidence: 64%

Translating Pharmacological Findings from Hypothyroid Rodents to Euthyroid Humans: Is There a Functional Role of Endogenous 3,5-T2?

Pietzner

Lehmphul

Friedrich

et al. 2015

Thyroid

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Background: During the last two decades, it has become obvious that 3,5-diiodothyronine (3,5-T2), a wellknown endogenous metabolite of the thyroid hormones thyroxine (T4) or triiodothyronine (T3), not only represents a simple degradation intermediate of the former but also exhibits specific metabolic activities. Administration of 3,5-T2 to hypothyroid rodents rapidly stimulated their basal metabolic rate, prevented highfat diet-induced obesity as well as steatosis, and increased oxidation of long-chain fatty acids. Objective: The aim of the present study was to analyze associations between circulating 3,5-T2 in human serum and different epidemiological parameters, including age, sex, or smoking, as well as measures of anthropometry, glucose, and lipid metabolism. Methods: 3,5-T2 concentrations were measured by a recently developed immunoassay in sera of 761 euthyroid participants of the population-based Study of Health in Pomerania. Subsequently, analysis of variance and multivariate linear regression analysis were performed. Results: Serum 3,5-T2 concentrations exhibited a right-skewed distribution, resulting in a median serum concentration of 0.24 nM (1st quartile: 0.20 nM; 3rd quartile: 0.37 nM). Significant associations between 3,5-T2 and serum fasting glucose, thyrotropin (TSH), as well as leptin concentrations were detected ( p < 0.05). Interestingly, the association to leptin concentrations seemed to be mediated by TSH. Age, sex, smoking, and blood lipid profile parameters did not show significant associations with circulating 3,5-T2. Conclusion: Our findings from a healthy euthyroid population may point toward a physiological link between circulating 3,5-T2 and glucose metabolism.

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Section: Figsupporting

confidence: 64%

Translating Pharmacological Findings from Hypothyroid Rodents to Euthyroid Humans: Is There a Functional Role of Endogenous 3,5-T2?

Pietzner

Lehmphul

Friedrich

et al. 2015

Thyroid

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“…These findings are in agreement with other studies in Table 4 Prepost intervention absolute differences (Δ) of each weight variation group. children and adults, although usually with a greater proportion of elevated fT3 levels than fT4 levels (1,3,6,8,13,17,26). All studied thyroid function parameters showed a significantly positive correlation with BMI-SDS, but only TSH and fT4 remained significant in the regression analysis.…”

Section: Discussionmentioning

confidence: 66%

Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study

Santos

Limbert

Marquês

et al. 2015

Journal of Pediatric Endocrinology and Metabolism

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Background: Serum thyroid stimulating hormone (TSH) levels are frequently elevated in obese children and are most likely to be associated with insulin resistance. However, clinical relevance of this association remains unclear. Objectives: To assess the prevalence of hyperthyrotropinemia; to analyze the relationship between TSH and homeostasis model assessment -insulin resistance (HOMA-IR); and to verify whether TSH levels and HOMA-IR vary with weight loss in obese children. Subjects and Methods: Retrospective longitudinal study with data from baseline and 1 year after lifestyle intervention in a pediatric obese group (344 children were recruited and 100 among them completed follow-up). For postintervention analysis, three groups were considered according to body mass index-standard deviation score (BMI-SDS) variations: ≤ -0.5 (significant weight loss); 0.5-0 (weight loss); and > 0 (weight gain). Statistical analysis was performed using SPSS 19.0

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“…This is despite the fact that there is a large body of evidence indicating that differences in metabolic rate can predict changes in weight (Ravussin et al 1988) and that an increase in peripheral metabolism such as after treatment with thyroid hormone or uncouplers of respiration such as dinitrophenol leads to weight loss (Grundlingh et al 2011, Pearce 2012. Moreover, while a defect in leptin signaling is associated with hyperphagia and a marked decrease in energy expenditure in mice, the principal effect in human is on appetite with little or no discernible effect on metabolism (Farooqi et al 1999).…”

Section: Obesity Has a Substantial Genetic Componentmentioning

confidence: 69%

20 YEARS OF LEPTIN: Leptin at 20: an overview

Friedman¹

2014

Journal of Endocrinology

204

146

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Historically, adipose tissue was considered to be a passive storage vessel discharging nutrients in times of famine and accumulating fat in times of surfeit. This view changed with the identification of leptin as an adipocyte hormone. Leptin functions as an afferent signal in a negative feedback loop that regulates food intake and metabolism to maintain homeostatic control of adipose tissue mass. Before this, the existence of a system maintaining homeostatic control of energy balance was unclear. The identification of leptin has thus uncovered a new endocrine system that also links changes in nutrition to adaptive responses in most if not all other physiologic systems. Further studies have revealed a set of clinical syndromes caused by leptin deficiency, including lipodystrophy and hypothalamic amenorrhea. This work has led to new therapeutic approaches for a number of human conditions and has also established a conceptual framework for studying the pathogenesis of obesity.

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Thyroid hormone and obesity

Abstract: The interrelationships between body weight and thyroid status are complex.

Cited by 148 publications

References 47 publications

Translating Pharmacological Findings from Hypothyroid Rodents to Euthyroid Humans: Is There a Functional Role of Endogenous 3,5-T2?

Translating Pharmacological Findings from Hypothyroid Rodents to Euthyroid Humans: Is There a Functional Role of Endogenous 3,5-T2?

Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study

20 YEARS OF LEPTIN: Leptin at 20: an overview

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