Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth

Williams, Graham R.; Robson, Helen; Shalet, Stephen M

doi:10.1677/joe.0.1570391

Cited by 64 publications

(47 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, there may be intrinsic functions for TRs in bone, as TR expression has been detected in growth plate chondrocytes (Williams et al 1998). Also, the formation of hypertrophic cells in the growth plate of thyroidectomized and hypophysectomized rats is stimulated by administration of thyroid hormones but not GH (Ray et al 1954;Lewinson et al 1989), and the maturation of growth plate chondrocytes in vitro can be regulated by thyroid hormones (Carrascosa et al 1992;Ohlsson et al 1992).…”

Section: The Growth Retardation Of Tr␣1mentioning

confidence: 99%

Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation

Göthe¹,

Wang²,

Ng³

et al. 1999

Genes & Development

417

259

View full text Add to dashboard Cite

Section: The Growth Retardation Of Tr␣1mentioning

confidence: 99%

Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation

Göthe¹,

Wang²,

Ng³

et al. 1999

Genes & Development

417

259

View full text Add to dashboard Cite

“…Transport and concentration of iodide into the milk by the lactating mammary gland has been known for decades (BrownGrant 1961, Grosvenor 1963. The milk iodide is used by the newborn for synthesis of thyroid hormone, a hormone which plays an essential role in development of the nervous system and bones (Williams et al 1998, Chan & Kilby 2000. Expression of NIS mRNA has been detected by RT-PCR in the mammary gland of lactating Wistar rats (Ajjan et al 1998b) and in the human breast (Smanik et al 1997, Spitzweg et al 1998.…”

Section: Introductionmentioning

confidence: 99%

Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues

Perron

Rodriguez²,

Leblanc³

et al. 2001

Journal of Endocrinology

View full text Add to dashboard Cite

Iodide concentration in milk by mammals is a necessary step for thyroid hormone synthesis by the newborn. With the purpose of using the mouse as an animal model to analyse the role of the sodium iodide symporter (NIS) in iodide transport and its regulation in the mammary gland, mouse NIS (mNIS) cDNA was isolated from lactating mice. The cloned sequence shows an open reading frame of 1854 nucleotides encoding a protein of 618 amino acids highly homologous to the rat and human NIS (95% and 81% identity respectively). Expression of mNIS in cultured mammalian cells induced cellular iodide accumulation. This iodide uptake process is sodium dependent and inhibited by thiocyanate and perchlorate. Tissue distribution analysis revealed that mNIS mRNAs are predominantly expressed in thyroid, stomach and in the lactating mammary gland and are present to a lower extent in several other tissues. Our data show for the first time that the level of mNIS mRNA is upregulated in the mammary gland during lactation.

show abstract

“…Thyroid hormone deficiency adversely affects the development of the central nervous system (Langsteger et al, 1994;Rodriguez-Pena, 1999;Bernal and Nunez, 1995), auditory system (Dussault and Ruel, 1987), and skeletal system (Sohmer and Freeman, 1996). Hypothyroidism also delays dental development and eruption (Williams et al, 1998).…”

Section: Growth and Developmentmentioning

confidence: 99%

Hypothyroidism in adults: A review and recent advances in management

Bello¹

2012

J. Diabetes Endocrinol.

View full text Add to dashboard Cite

Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone or, more rarely, from their impaired activity at tissue level. In its clinically overt form, hypothyroidism is a relatively common condition, with an approximate prevalence of 2% in adult women and 0.2% in adult men. Deficiency of the hormone has a wide range of effects, because all metabolically active cells require thyroid hormone. The clinical features of hypothyroidism are dependent on the patient's age, the presence of other disease, and the rate at which hypothyroidism develops. Early detection and proper management is very important. Under treatment leads to disease progression with gradual worsening of symptoms and further metabolic derangements. Fortunately, in most patients older than 3 years, the signs and symptoms of hypothyroidism are reversed with thyroid hormone treatment. A constant reminder on progress in management of the disease is needed. Thus, the aim of this review is to bring to notice the recent advances in the diagnosis and management of hypothyroidism and to highlight the risks involved in the global movement from consuming organic animals (as the world moves towards inorganic foods, which inhibits thyroid hormones).

show abstract

Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth

Cited by 64 publications

References 104 publications

Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation

Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation

Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues

Hypothyroidism in adults: A review and recent advances in management

Contact Info

Product

Resources

About