Thyroid gland dysfunction and its effect on the cardiovascular system: a comprehensive review of the literature

Ahmadi, Navid; Ahmadi, Faisal; Sadiqi, Masehullah; Mińczykowski, Andrzej

doi:10.5603/ep.a2020.0052

Cited by 20 publications

(11 citation statements)

References 109 publications

(170 reference statements)

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“…Previous studies demonstrated that subclinical hypothyroidism is associated with impaired systolic and diastolic function of the left ventricle (LV), but some adverse changes can be reversed by levothyroxine therapy [7]. Despite the known effects of thyroid hormones on the CV system [8], the number of studies evaluating the effects of thyroid autoimmunity on cardiac function is limited. Antithyroid peroxidase antibodies (aTPO) are frequently detected in T1DM patients (up to 50%), but their importance during euthyroidism has not been sufficiently studied [9].…”

Section: Echocardiographymentioning

confidence: 99%

Association of antithyroid peroxidase antibodies with cardiac function in euthyroid women with type 1 diabetes mellitus — assessment with two-dimensional speckle‑tracking echocardiography

et al. 2022

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Introduction:The presence of diabetes is associated with loss of cardioprotection in premenopausal women; however, the mechanisms involved remain unknown. Autoimmune factors are suspected to play a role in cardiovascular complications, especially in type 1 diabetes (T1DM). The aim of this pilot study was to explore whether antithyroid peroxidase antibody (aTPO) as a marker of increased immune activity is related to cardiac dysfunction in young, asymptomatic women with T1DM. Material and methods: Eighty-eight euthyroid women (59 with T1DM and 29 healthy controls) underwent physical examination, laboratory tests, thyroid ultrasound, and two-dimensional speckle-tracking echocardiography. According to the antiperoxidase antibodies (aTPO) titre, the T1DM women were divided into an aTPO positive (T1DM aTPO+) (n = 34) and an aTPO negative (T1DM aTPO-) (n = 25) group. The relationship between thyroid autoimmunity parameters and echocardiographic parameters was evaluated. Results: Global longitudinal strain (GLS) was slightly reduced in the T1DM aTPO+ group compared to T1DM aTPO-and significantly compared to controls (p = 0.051 and p = 0.015, respectively). Although, the lower values of longitudinal strain of left ventricular were found in the majority of segments in the T1DM aTPO+ group in comparison to T1DM aTPO-and controls, significant differences were only found in the two-chamber view (specifically in the anterior segments) between the T1DM aTPO+ and T1DM aTPO-groups (p = 0.030) and in the four-chamber view (specifically in the anterolateral segments) between the T1DM aTPO+ group and controls (p = 0.021). Echocardiographic parameters of diastolic and systolic function of both ventricles were significantly correlated with parameters of thyroid autoimmunity. A logistic regression analysis showed that Hashimoto's thyroiditis (HT) duration [odds ratio (OR): 0.997, 95% confidence interval (CI): 0.995-0.999, p = 0.008), the dose of levothyroxine (OR: 0.814, 95% CI: 0.689-0.960, p = 0.013), and reduced echogenicity on thyroid ultrasound (OR: 0.309, 95% CI: 0.120-0.793, p = 0.013) had a significant influence on reduced GLS. Conclusions: Our results suggest that coexistence of aTPO with T1DM was associated with poorer myocardial function, particularly in the anterior and anterolateral segments, which may be related to an autoimmune factor. The impaired function of these segments is probably the first sign of myocardial systolic dysfunction in women with T1DM, which needs to be confirmed in further studies.

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Section: Echocardiographymentioning

confidence: 99%

Association of antithyroid peroxidase antibodies with cardiac function in euthyroid women with type 1 diabetes mellitus — assessment with two-dimensional speckle‑tracking echocardiography

et al. 2022

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“…[10][11] In addition, the patient is a woman smoker, uses contraceptive pill, has a strong cardiovascular family history, unmedicated hyperthyroidism and dyslipidemia, potentiating the hypercoagulable state and arterial cardiovascular disease. 12 The clinical impact of the MTHFR A 1298C allele on thrombotic risk, regardless of homocysteine levels, is controversial. 13 Some recent evidence suggests that the high thrombotic load in STEMI patients may lead to a benefit of adding a direct oral anticoagulant to antiplatelet therapy, reducing the risk of cerebrovascular events in selected patients.…”

Section: Referencesmentioning

confidence: 99%

Cardiocerebral Infarction: A Combination to Prevent

Cabral¹,

Ponciano²,

Santos³

2022

International Journal of Cardiovascular Sciences

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“…[8][9][10] Amiodarone-induced thyrotoxicosis is linked to significant cardiac morbidity and mortality, especially in patients with HFrEF, owing to an overlap of preexisting impaired ventricular function and a high output thyrotoxic state, precipitating heart failure in these patients. 11,12 Also, AIT may exacerbate arrhythmic instability, 13 with documented cases of electric storm. 14 So, it is vital to assure a rapid restoration and maintenance of euthyroidism in such cases.…”

Section: Introductionmentioning

confidence: 99%

Total thyroidectomy in a patient awaiting heart transplant with amiodarone‐induced thyrotoxicosis: A case report

Amador

Mendonça

Costa

et al. 2023

Clinical Case Reports

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Thyroid gland dysfunction and its effect on the cardiovascular system: a comprehensive review of the literature

Cited by 20 publications

References 109 publications

Association of antithyroid peroxidase antibodies with cardiac function in euthyroid women with type 1 diabetes mellitus — assessment with two-dimensional speckle‑tracking echocardiography

Association of antithyroid peroxidase antibodies with cardiac function in euthyroid women with type 1 diabetes mellitus — assessment with two-dimensional speckle‑tracking echocardiography

Cardiocerebral Infarction: A Combination to Prevent

Total thyroidectomy in a patient awaiting heart transplant with amiodarone‐induced thyrotoxicosis: A case report

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