Thyroid Functional Status in Chronic Kidney Disease

Hossain, Mosharruf; Shah, Kabiruzzaman; Begum, Noorzahan; Ahmed, Parvez; Islam, Akm Monoarul; Chowdhury, Nurul Islam

doi:10.3329/bjnm.v18i2.35222

Cited by 5 publications

(8 citation statements)

References 4 publications

(4 reference statements)

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“…In our study, majority of patients included in the study with Chronic Kidney Disease were in the age group of 50-60 years (Table 1). Similar to our study, Md Mosharruf Hossain et al [17] showed that prevalence of thyroid dysfunction in patients with Chronic Kidney Disease were more in the age group of 50-60 years. In contrast to our study, Abhishek Gupta et al [4] showed that patients of Chronic Kidney Disease with thyroid dysfunction were more in the age group of 40-50 years.…”

Section: Discussionsupporting

confidence: 91%

“…One of the major worldwide public health problems is CKD. According to WHO, 2004, they are the 12th cause of death and 17th cause of disability in the world [17]. In patients with CKD, several alterations in thyroid function has been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Punekar et al [6] the male:female ratio was 1.08:1 in case group. In a study by Upendra Nath Gupta et al [23] out of 100 patients of CKD, 60 were Male and 40 of them were Female and in a study by Md Mosharruf Hossain et al [17] 63% patients were Male and 37% were Female giving rise to a Male:Female ratio of nearly 1.7:1.In contrast to our study Abhishek Gupta et al [4] showed that prevalence of SCH was more in Females (52%) compared to Males (48%). In our study, majority of patients included in the study with Chronic Kidney Disease were in the age group of 50-60 years (Table 1).…”

Section: Discussionmentioning

confidence: 99%

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Thyroid Function Test in Patients with Chronic Kidney Disease

Abhinaya

Kumar

2021

JPRI

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Background: Kidneys have a significant role in the metabolism, degradation and excretion of thyroid hormones. Both thyroid hormones and kidney functions have a multifaceted mutual interdependence. Objectives: To find out the possible association between the severity of chronic kidney disease and thyroid dysfunction; To estimate the correlation between thyroid dysfunction and various stages of chronic kidney disease. Materials and Methods: A prospective Cross-sectional study was done on 50 patients with Chronic kidney disease who were not on dialysis and fulfilled all the inclusion criteria at Saveetha medical college over a period of 6 months. Free T3, Free T4 and TSH levels were estimated for those patients. Results: Results of this study showed that majority of subjects included in our study were in the age group of 50-60 years with Male predominance. Out of 50 patients included in our study, 8 patients(16%) were found to hypothyroidism; 5 patients (10%) were having subclinical hypothyroidism; 20 patients (40%) were having low T3 syndrome and 17 patients (34%) were having normal functioning thyroid gland. Staging of CKD was done in relation to the glomerular filtration rate .Most of the patients(n=20) were in Stage 5 of Chronic kidney disease out of which 18 patients were having thyroid disorders. Conclusion: There is a positive correlation between the severity of CKD and thyroid dysfunction. Hence a routine thyroid function status should be evaluated in each and every patient of CKD to reduce the morbidity and mortality rate of CKD patients as well as reduce the social burden and health expenditure.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Thyroid Function Test in Patients with Chronic Kidney Disease

Abhinaya

Kumar

2021

JPRI

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“…Reports suggest that progression of CKD is associated with having a number of complications, including thyroid dysfunction (4). Impairment in kidney function leads to disturbed thyroid physiology, all levels of the hypothalamic pituitary thyroid axis may be involved, including alterations in hormone production, distribution, and excretion (11). Leptin is linked to the development of CKD in the absence of obesity, as patients with ESRD have an estimated 4-7.5 fold increase in plasma leptin concentration (hyperleptinemia) compared with healthy control subjects (12).…”

Section: Discussionmentioning

confidence: 99%

“…These finding are similar to the results from (15), who showed significant increase in the level of TSH in the CKD patients compared with the controls. In the existing (11,16,17). The result of current study is in conflict with study done by Khatiwada et al, (18), who observed decreasing trend for T3 and T4 levels (though the decrease was not significant), and increasing trend for TSH level (significant rise) across CKD stages 3-5, which suggest that TSH level increases with the progression of renal impairment.…”

Section: Discussionmentioning

confidence: 99%

Hypothyroidism and Leptin in Iraqi Patients with Chronic Kidney Disease

2021

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The present study aims at assessing the effects of chronic kidney disease (CKD) on thyroid hormone and leptin by evaluating the level of: leptin hormone along with thyroid hormone in CKD patients. The study has been conducted on 70 subjects, 50 patients with an age range between 20-50 years (25 males and 25 females) who were diagnosed to have CKD stage-5, and 20 normal controls whose ages ranged between 20-48 years (10 males and 10 females), who attended the Nephrology and Transplant Center in Medical City of Baghdad- Iraq from April 2018 to July 2018. The study showed a highly significant (P<0.01) increase in TSH level in CKD patients in comparison with controls. While T3 and T4 levels observed highly significant decrease (P<0.01) in CKD patients in comparison with their control groups; on the other hand, in Leptin levels, it has been demonstrated a highly significant (P<0.01) increase in CKD patients compared to the controls. Also there was a significant (P<0.05) positive correlation between TSH and Leptin, while the results showed a highly significant (P<0.01) negative correlation between T3, T4 and Leptin. To conclude, this study confirms that thyroid dysfunction and hyperleptinemia have been found to be very common in CKD patients and reveals the significant association between CKD progression and thyroid dysfunction and hyperleptinemia.

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Hypothyroidism and AMH in Iraqi Patients with Chronic Kidney Disease

2021

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This study was conducted to investigate thyroid function and Anti-Müllerian hormone (AMH) in (Chronic kidney disease) CKD patients by evaluating their levels in CKD patients, 50 patients were diagnosed to have CKD stage-5, their ages ranged between 20-50 years (25 males and 25 females) who attended the Nephrology and Transplant Center in Medical City of Baghdad-Iraq, they were recruited from April 2018 to July 2018 and were enrolled into the study. The control group consisted of 20 healthy individuals, their ages ranged between 20-48 years (10 males and 10 females). The study showed nonsignificant (p>0.05) increase in AMH level in CKD patients compared to the control group. On the other hand, TSH was recorded a highly significant (P<0.01) increase in CKD patients in comparison with control. While T3 and T4 levels recorded highly significant (P<0.01) decrease in CKD patients in comparison with control.

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Thyroid Functional Status in Chronic Kidney Disease

Abstract: ABSTRACT

Cited by 5 publications

References 4 publications

Thyroid Function Test in Patients with Chronic Kidney Disease

Thyroid Function Test in Patients with Chronic Kidney Disease

Hypothyroidism and Leptin in Iraqi Patients with Chronic Kidney Disease

Hypothyroidism and AMH in Iraqi Patients with Chronic Kidney Disease

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