Thyroid Function Tests in Persons with Occupational Exposure to Fipronil

Hérin, Fabrice; Boutet-Robinet, Élisa; Levant, Aude; Dulaurent, Sylvain; Manika, Mimoza; Galatry-Bouju, Florence; Caron, Philippe; Soulat, Jean-Marc

doi:10.1089/thy.2010.0449

Cited by 39 publications

(32 citation statements)

References 44 publications

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“…The median from the occupational exposure study was calculated from the mean (μ) and standard deviation (σ) provided via a method by Pleil et al (2014) where the geometric mean is used to estimate the median which is equal to μ/[1 + 0.5 × (σ/μ) 2 ]. Interestingly, the maximum concentration observed in this study (3.9 ng/mL) was only slightly less than the calculated median of 5.2 (GSD = 2.4) ng/mL for the occupationally exposed workers (Herin et al, 2011) (see Fig. 2), where error is represented in terms of the geometric standard deviation (GSD).…”

Section: Discussioncontrasting

confidence: 66%

“…The dotted line represents the median calculated from an occupational exposure study (Herin et al, 2011; Pleil et al, 2014). * n = 96, four samples were excluded due to insufficient volume.…”

Section: Figmentioning

confidence: 99%

“…Although one occupational exposure study of workers ( n = 159) at a fipronil production facility reported a mean fipronil sulfone serum level of 7.8 (+/− 7.7 = SD) ng/mL (Herin et al, 2011), very little is known about human exposure to fipronil in the general population (Mohamed et al, 2004; Vidau et al, 2011; Herin et al, 2011). This may be because human samples can be difficult to obtain and analyze due to high concentrations of endogenous chemicals and significant matrix effects which make the identification of metabolites difficult.…”

Section: Introductionmentioning

confidence: 99%

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Identification of fipronil metabolites by time-of-flight mass spectrometry for application in a human exposure study

McMahen

Strynar

Dagnino

et al. 2015

Environment International

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Fipronil is a phenylpyrazole insecticide commonly used in residential and agricultural applications. To understand more about the potential risks for human exposure associated with fipronil, urine and serum from dosed Long Evans adult rats (5 and 10 mg/kg bw) were analyzed to identify metabolites as potential biomarkers for use in human biomonitoring studies. Urine from treated rats was found to contain seven unique metabolites, two of which had not been previously reported—M4 and M7 which were putatively identified as a nitroso compound and an imine, respectively. Fipronil sulfone was confirmed to be the primary metabolite in rat serum. The fipronil metabolites identified in the respective matrices were then evaluated in matched human urine (n = 84) and serum (n = 96) samples from volunteers with no known pesticide exposures. Although no fipronil or metabolites were detected in human urine, fipronil sulfone was present in the serum of approximately 25% of the individuals at concentrations ranging from 0.1 to 4 ng/mL. These results indicate that many fipronil metabolites are produced following exposures in rats and that fipronil sulfone is a useful biomarker in human serum. Furthermore, human exposure to fipronil may occur regularly and require more extensive characterization.

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Section: Discussioncontrasting

confidence: 66%

Section: Figmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Identification of fipronil metabolites by time-of-flight mass spectrometry for application in a human exposure study

McMahen

Strynar

Dagnino

et al. 2015

Environment International

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“…However, other signs of toxicity were observed including convulsions, head nodding and muscles twitching (Hamernik 1998; Woodward 2012). Herin et al (2011) assessed serum concentrations of thyroid-stimulating hormone (TSH), fipronil and fipronil sulfone in 159 workers in a factory manufacturing fipronil-containing veterinary drugs. They found a significant positive correlation between exposure and fipronil/fipronil sulfone concentration in the blood.…”

Section: Introductionmentioning

confidence: 99%

Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil

Vasylieva

Barnych

Wan

et al. 2017

Environment International

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Occupational medical surveillance is highly desirable in manufacturing facilities where exposure to chemicals is significant. The insecticide fipronil is generally considered safe for humans but with increasing use, exposure to fipronil is of concern. Identification of urinary metabolites of fipronil may allow development of affordable, cheap and rapid procedures for human exposure evaluation. In this study we developed a fast and easy approach for synthesis of hydroxy-fipronil, a potential urinary metabolite of fipronil. This standard was used to develop a sensitive analytical LC-MS/MS method with a limit of quantification (LOQ) of 0.4 ng/mL. Fipronil sulfone, a known metabolite, and hydroxy-fipronil were quantified in urine samples from rats treated with a fipronil containing diet. Fipronil sulfone concentration centered around 20 ng/mL, while the concentration of hydroxy-fipronil was dose-dependent ranging in 10–10 000 ng/mL and thus being a more sensitive marker of fipronil exposure. A fipronil immunoassay with cross-reactivity to hydroxy-fipronil showed a good correlation in signal intensity with LC-MS data. It was also used to demonstrate the applicability of the method for sample screening in the evaluation of exposure levels.

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“…However, nowadays there is greater awareness of the risk of long term effects attributable to frequent exposure to doses of low concentrate pesticides (Kapoor et al 2011; Herin et al 2011). Also, new studies revealed the close relationship between the chronic health effects that become apparent at a given moment in life and the prolonged or repeated exposure to low doses of pesticides at earlier ages (Winans et al 2011; Bailey et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Knowing the enemy: ant behavior and control in a pediatric hospital of Buenos Aires

et al. 2014

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Ant control is difficult in systems even where a variety of control strategies and compounds are allowed; in sensitive places such as hospitals, where there are often restrictions on the methods and toxicants to be applied, the challenge is even greater. Here we report the methods and results of how we faced this challenge of controlling ants in a pediatric hospital using baits. Our strategy was based on identifying the species present and analyzing their behavior. On the one hand, we evaluated outdoors in the green areas of the hospital, the relative abundance of ant genera, their food preferences and the behavioral dominances. On the other hand, control treatments were performed using separately two boron compounds added to sucrose solution which was not highly concentrated to avoid constrains due to the viscosity.Most of the species in the food preference test accepted sugary food; only one species was recorded to visit it less than the protein foods. This result was consistent with the efficacy of control treatments by sugary baits within the rooms. For species that showed good acceptance of sugar solutions in the preference test outdoors, sugar bait control indoors was 100& effective. Conversely, for the only species that foraged significantly less on sugar food, the bait treatment was ineffective. This work reveals the importance of considering the behavior and feeding preferences of the species to be controlled by toxic baits.

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Thyroid Function Tests in Persons with Occupational Exposure to Fipronil

Cited by 39 publications

References 44 publications

Identification of fipronil metabolites by time-of-flight mass spectrometry for application in a human exposure study

Identification of fipronil metabolites by time-of-flight mass spectrometry for application in a human exposure study

Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil

Knowing the enemy: ant behavior and control in a pediatric hospital of Buenos Aires

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