Thyroid function tests in cases of polymorphic light eruption: A case-control study

Abstract

Background:Polymorphic light eruption (PLE) has been found to be associated with thyroid function abnormalities.Aim:To study clinicoepidemiological features of PLE and to study and compare thyroid function tests (TFTs) in cases of PLE.Materials and Methods:The study included 100 cases of PLE and age- and sex-matched controls attending a skin outpatient department. The clinical and epidemiological features were recorded. Both cases and controls were tested for thyroid-stimulating hormone (TSH). In case of abnormality in TSH, triiodothyronine (T3) and tetraiodothyronine (T4) levels were estimated.Results:TFT was abnormal in 25 cases and 7 controls. TSH was elevated in 24 cases and 6 controls and decreased in 1 case and 1 control. T3 and T4 were decreased in 18 cases and 6 controls and elevated in 1 each in case and control. Hypothyroidism was significantly high among cases than controls.Discussion:TFT abnormality was significantly higher among cases than controls. Hypothyroidism has a significant association with PLE. Genetic basis or immune dysfunction may be the cause of both the diseases. PLE may be considered as a clinical presentation of thyroid function disorder and vice versa.Conclusion:Cases of PLE should be examined clinically for thyroid disorder and also tested for TSH or TFT to find any association and prevent serious consequences.

Study of Thyroid Function Tests in Cases of Polymorphic Light Eruption in Tertiary Care Institute

“…It was found statistically significant. This findings correlate well with the study conducted by Sharma et al 7 ., in 2014 in which TSH was high in 24%, low in 1% of cases and high in 6%, low in 1% of controls Chi square-31, df-17, P value -0.01 (S) In our study, low T3 and T4 level were found only in 11.42% of cases. While T3 and T4 level were normal in 5.71% cases and 2.85% controls which was not statistically significant ( Table 2).…”

Immunopathogenesis and management of polymorphic light eruption

“…Thyroid dysfunction is not rare in PLE. Indeed, hypothyroidism is detected significantly more often in patients with PLE than in controls 7,37 . It has been recently shown that in state of hypothyroidism, the skin has an increased lipid peroxidation due to a decreased antioxidant defense 38 .…”

Biochemical Correlation of Thyroid Dysfunction Among Patients Presenting With Polymorphic Light Eruption

“…In a study by Seetharam et al, [ 4 ] nearly 25.9% cases were hypothyroid along with polymorphic light eruption, and only 7.5% of controls were hypothyroid. Sharma et al, [ 3 ] in 2014 found out that nearly 18% cases and 5% of controls were found to have overt hypothyroidism along with subclinical hypothyroidism in 6% cases and 1% controls. Hasan et al, [ 5 ] found out that polymorphic light eruption had an autoimmune basis for origin and females showed a higher number of cases compared to males.…”

“…In dermatoses such as melasma and polymorphic light eruption which are sunlight-associated, thyroid function disorders have been noted [3][4][5]. Herein we describe a comparative study of biochemical evaluation of thyroid function test carried out among 60 cases of PMLE with an equal number of controls.…”

“…It can affect healthy individuals on exposure to sunlight or artificial light, usually, there is no history or intake of photosensitizing agents. The main pathomechanism still remains unclear, but many theories speculate about its possible autoimmune origins [ 3 ].…”