Thyroid Function Studies in Normal and Gold‐Exposed Rabbits Using ¹²⁵I

Abstract

CARLSON, L. D., H. V. ROOHK and 0. WILSON. Thyroid fuiictiori studics in normal atzd cold-cxposed rabbits using 1L31. Acta physiol. scand. 1973. 89. 359-373. Normal uptake and retention of 1251 in thyroid was measured for 2-17 weeks in rabbits, and the effect of TSH, T-l, acute and extended cold exposure was studied. There were marked interindividual variations in maximum uptake (mean 7 70, range 2.5-18 %), in time to peak I , I

Binding of Thyroid Hormone in Rabbit Serum: Definition of a Prealbumin and Effects of Strain Variation on Binding

“…It is possible that, as in the mouse (Chai & Melloh, 1972), selective breeding results in different genetically controlled rates of thyroidal iodine release; such differences in eumetabolic animals could primarily determine the level of thyroid hormone in the blood. Wide inter-individual differences in thyroidal radio-iodide uptake and release rates have in fact been reported in rabbits maintained under identical conditions, although genetic factors were not specifically studied (Carlson, Roohk & Wilson, 1973).…”