THYROID FUNCTION STUDIES IN CHILDREN: NORMAL VALUES FOR THYROIDAL I<sup>131</sup>UPTAKE AND PBI<sup>131</sup>LEVELS UP TO THE AGE OF 18*

Oliner, Leo; Kohlenbrener, Robert M.; Fields, Theodore; Kunstadter, Ralph H.; Goldstein, Dolores R.

doi:10.1210/jcem-17-1-61

Cited by 45 publications

(18 citation statements)

References 22 publications

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“…Concernant les enfants, plusieurs études ne montrent pas de différence de captage par rapport aux adultes (Cuddihy, 1966 ;Oliner et al, 1957). Chez l'adolescent, en revanche, se produit une accélération des échanges d'iode : la clairance et le captage thyroïdiens ainsi que la clairance rénale sont augmentés et la demi-vie de l'iode au sein de la thyroïde est plus courte que pour l'adulte (Malvaux, 1985).…”

Section: âGeunclassified

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Pharmacocinétique de l'iode : revue des connaissances utiles en radioprotection accidentelle

2000

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Section: âGeunclassified

“…Mais ce résul-tat n'est pas constamment retrouvé (Tubiana et al, 1958). Une étude réalisée chez des sujets âgés de 2 mois à 18 ans ne montre pas de différence en fonction du sexe (Oliner et al, 1957).…”

Section: Sexeunclassified

Pharmacocinétique de l'iode : revue des connaissances utiles en radioprotection accidentelle

2000

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“…(An73) also observed high rates of l3'I uptake in newborn children which decreased progressively with age into early adulthood. Oliner et al (0157) describe a state of hyperactivity in the thyroid gland which exists through the age of 4yr and possibly longer. This state is characterized by elevated levels of protein-bound iodine, even when 24-hr uptake is not significantly higher than the normal adult.…”

Section: Uptake Of Iodine In the Thyroidmentioning

confidence: 99%

Variability of Human Thyroid Characteristics and Estimates of Dose from Ingested 131I

De¹,

Schwarz²

1981

Health Physics

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An important step in the assessment of dose to man from environmental releases of radionuclides is the estimation of dose per unit intake. Large uncertainties may be associated with estimates of dose due to variability in human physiological and metabolic characteristics. An evaluation of variability in three principal biological parameters (thyroid mass, uptake and retention of ingested iodine in the thyroid gland) used in calculation of dose to the human thyroid gland from ingested I3'I has been performed for several age categories. The resulting imprecision in predicted thyroid dose commitment per unit intake for each age group is estimated using Monte-Carlo sampling procedures. The ratio of the 99th percentile estimate of dose to the mean estimate is approx. 3 for each of the age groups. The importance of this uncertainty in dose estimates is discussed, including potential implications for radiation protection.

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“…Thus, the overall trend in Figure 4 suggests FIG. 2. Measured 24-h thyroid radioiodide uptake (% dose) in the human from birth to 48 yr. Data shown were obtained from Fisher and Oddie (1964), Kearns and Phillipsborn (1962), Martmer et al (1956), Ogborn et al (1960), Oliner et al (1957), Quimby and McCune. (1947), Reilly and Bayer (1952), Van Dilla and Fulwyler (1964), Van Middlesworth et al (1953), Fisher et al (1962), and Wellman et al (1970).…”

Section: Iodide Model Parameterization Gestation Modelmentioning

confidence: 99%

Perchlorate and Radioiodide Kinetics Across Life Stages in the Human: Using PBPK Models to Predict Dosimetry and Thyroid Inhibition and Sensitive Subpopulations Based on Developmental Stage

Clewell

Merrill²,

Gearhart

et al. 2007

Journal of Toxicology and Environmental Health, Part A

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Perchlorate (ClO4(-)) is a drinking-water contaminant, known to disrupt thyroid hormone homeostasis in rats. This effect has only been seen in humans at high doses, yet the potential for long term effects from developmental endocrine disruption emphasizes the need for improved understanding of perchlorate's effect during the perinatal period. Physiologically based pharmacokinetic/dynamic (PBPK/PD) models for ClO4(-) and its effect on thyroid iodide uptake were constructed for human gestation and lactation data. Chemical specific parameters were estimated from life-stage and species-specific relationships established in previously published models for various life-stages in the rat and nonpregnant adult human. With the appropriate physiological descriptions, these kinetic models successfully simulate radioiodide data culled from the literature for gestation and lactation, as well as ClO4(-) data from populations exposed to contaminated drinking water. These models provide a framework for extrapolating from chemical exposure in laboratory animals to human response, and support a more quantitative understanding of life-stage-specific susceptibility to ClO4(-). The pregnant and lactating woman, fetus, and nursing infant were predicted to have higher blood ClO4(-) concentrations and greater thyroid iodide uptake inhibition at a given drinking-water concentration than either the nonpregnant adult or the older child. The fetus is predicted to receive the greatest dose (per kilogram body weight) due to several factors, including placental sodium-iodide symporter (NIS) activity and reduced maternal urinary clearance of ClO4(-). The predicted extent of iodide inhibition in the most sensitive population (fetus) is not significant (approximately 1%) at the U.S. Environmental Protection Agency reference dose (0.0007 mg/kg-d).

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THYROID FUNCTION STUDIES IN CHILDREN: NORMAL VALUES FOR THYROIDAL I¹³¹UPTAKE AND PBI¹³¹LEVELS UP TO THE AGE OF 18*

Cited by 45 publications

References 22 publications

Pharmacocinétique de l'iode : revue des connaissances utiles en radioprotection accidentelle

Pharmacocinétique de l'iode : revue des connaissances utiles en radioprotection accidentelle

Variability of Human Thyroid Characteristics and Estimates of Dose from Ingested 131I

Perchlorate and Radioiodide Kinetics Across Life Stages in the Human: Using PBPK Models to Predict Dosimetry and Thyroid Inhibition and Sensitive Subpopulations Based on Developmental Stage

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THYROID FUNCTION STUDIES IN CHILDREN: NORMAL VALUES FOR THYROIDAL I131UPTAKE AND PBI131LEVELS UP TO THE AGE OF 18*

Cited by 45 publications

References 22 publications

Pharmacocinétique de l'iode : revue des connaissances utiles en radioprotection accidentelle

Pharmacocinétique de l'iode : revue des connaissances utiles en radioprotection accidentelle

Variability of Human Thyroid Characteristics and Estimates of Dose from Ingested 131I

Perchlorate and Radioiodide Kinetics Across Life Stages in the Human: Using PBPK Models to Predict Dosimetry and Thyroid Inhibition and Sensitive Subpopulations Based on Developmental Stage

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Product

Resources

About

THYROID FUNCTION STUDIES IN CHILDREN: NORMAL VALUES FOR THYROIDAL I¹³¹UPTAKE AND PBI¹³¹LEVELS UP TO THE AGE OF 18*