Thyroid Function Screening in Children and Adolescents With Mood and Anxiety Disorders

Luft, Marissa J.; Aldrich, Stacey L.; Poweleit, Ethan A.; Prows, Cynthia A.; Martin, Lisa; DelBello, Melissa P.; Keeshin, Brooks; Ramsey, Laura B.

doi:10.4088/jcp.18m12626

Cited by 8 publications

(2 citation statements)

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“…In another study, Zheng et al 36 developed an NLP-based tool, capable of extracting clinical characteristics of patients with hypothyroidism from EHRs based on phenotypes collected from an array of medical resources, with an accuracy rate of over 97%. 36 Finally, Luft et al 26 used NLP to extract clinical features from EHRs from a cohort of pediatric patients with mood and anxiety disorders and correlated them with abnormal thyroid stimulating hormone levels.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Natural Language Processing Methods and Applications in Thyroidology

Loor-Torres,

Duran,

Toro-Tobon

et al. 2024

Mayo Clinic Proceedings: Digital Health

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Section: Resultsmentioning

confidence: 99%

A Systematic Review of Natural Language Processing Methods and Applications in Thyroidology

Loor-Torres,

Duran,

Toro-Tobon

et al. 2024

Mayo Clinic Proceedings: Digital Health

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“…The hypothalamus-pituitary-adrenal (HPA) and hypothalamus-pituitary-thyroid (HPT) axes are affected in a considerable proportion of patients with major depressive disorder (MDD) (e.g., 1 , 2 ), and endocrine dysfunction of both axes is hypothesized to be closely related (e.g., 3 , 4 ). While it is acknowledged that the HPA axis is a major endocrine cause of HPT axis dysfunction in adults, the functional relationship between both axes is not fully understood and has not been studied in MDD in children and adolescents so far.…”

Section: Introductionmentioning

confidence: 99%

Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression

et al. 2021

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In adults with major depressive disorder (MDD), a dysfunction between the hypothalamus-pituitary-adrenal (HPA) and the hypothalamus-pituitary-thyroid (HPT) axis has been shown, but the interaction of both axes has not yet been studied in adolescent major depressive disorder (MDD). Data from 273 adolescents diagnosed with MDD from two single center cross-sectional studies were used for analysis. Serum levels of thyrotropin (TSH), free levothyroxine (fT4), and cortisol were determined as indicators of basal HPT and HPA axis functioning and compared to that of adolescent controls by t-tests. Quantile regression was employed in the sample of adolescents with MDD to investigate the relationship between both axes in the normal as well as the pathological range of cortisol levels, considering confounders of both axes. In adolescent MDD, cortisol levels and TSH levels were significantly elevated in comparison to controls (p = <.001, d = 1.35, large effect size, and p = <.001, d = 0.79, moderate effect size, respectively). There was a positive linear relationship between TSH and cortisol (p = .003, d = 0.25, small effect size) at the median of cortisol levels (50th percentile). However, no relationship between TSH and cortisol was found in hypercortisolemia (cortisol levels at the 97.5th percentile). These findings imply that HPT and HPA axis dysfunction is common in adolescents with MDD and that function of both axes is only loosely related. Moreover, the regulation of the HPA and HPT axis are likely subjected to age-related maturational adjustments since findings of this study differ from those reported in adults.

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Treatment of hypothyroidism in infants, children and adolescents

Rodríguez

Dinauer

Francis

2022

Trends in Endocrinology & Metabolism

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Thyroid Function Screening in Children and Adolescents With Mood and Anxiety Disorders

Cited by 8 publications

References 0 publications

A Systematic Review of Natural Language Processing Methods and Applications in Thyroidology

A Systematic Review of Natural Language Processing Methods and Applications in Thyroidology

Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression

Treatment of hypothyroidism in infants, children and adolescents

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